ClinCalc DrugStats Database

Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2022

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Rank	Drug Name	Total Prescriptions (2022)	Total Patients (2022)	Annual Change
1	Atorvastatin	109,582,746	27,935,702	0
2	Metformin	86,747,907	19,536,027	0
3	Lisinopril	82,513,967	20,314,304	1
4	Levothyroxine	82,431,914	18,130,331	1
5	Amlodipine	70,766,211	17,789,649	0
6	Metoprolol	65,245,216	15,542,999	0
7	Albuterol	59,075,269	19,265,334	0
8	Losartan	53,555,510	13,150,031	0
9	Omeprazole	52,132,950	13,802,111	0
10	Gabapentin	40,141,486	9,889,546	0
11	Sertraline	39,891,990	8,422,729	0
12	Hydrochlorothiazide	38,153,288	9,758,721	0
13	Rosuvastatin	37,095,971	9,721,324	0
14	Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	34,690,297	4,652,545	3
15	Escitalopram	30,750,612	7,493,104	0
16	Pantoprazole	30,670,528	7,979,792	3
17	Montelukast	29,187,952	6,825,788	3
18	Trazodone	27,363,318	5,759,352	4
19	Simvastatin	26,459,069	6,986,630	3
20	Tamsulosin	25,306,357	6,758,617	4
21	Bupropion	25,197,923	6,111,736	3
22	Fluoxetine	24,014,263	5,174,534	3
23	Acetaminophen; Hydrocodone	23,521,228	7,972,417	3
24	Furosemide	23,067,424	5,845,466	3
25	Fluticasone	22,557,458	7,453,010	2
26	Amoxicillin	20,465,164	15,998,871	12
27	Apixaban	19,420,949	4,494,660	6
28	Insulin Glargine	18,983,905	3,808,867	1
29	Meloxicam	18,859,721	6,284,853	3
30	Prednisone	18,201,857	8,722,579	2
31	Duloxetine	18,066,468	4,042,916	4
32	Methylphenidate	17,705,265	2,586,485	11
33	Ibuprofen	17,493,911	9,340,903	3
34	Carvedilol	17,067,595	4,472,118	8
35	Potassium Chloride	16,993,841	4,513,952	5
36	Aspirin	16,981,811	5,095,974	2
37	Pravastatin	16,317,126	3,949,800	2
38	Ergocalciferol	15,914,322	4,987,258	3
39	Allopurinol	15,235,132	3,867,218	1
40	Citalopram	15,047,663	3,540,540	9
41	Alprazolam	14,988,526	3,336,114	1
42	Glipizide	14,521,604	3,697,042	6
43	Cetirizine	13,899,342	4,436,602	6
44	Venlafaxine	13,881,022	2,844,672	0
45	Cyclobenzaprine	13,724,245	5,016,775	0
46	Hydroxyzine	13,652,751	3,675,422	12
47	Clopidogrel	13,568,821	3,767,583	10
48	Semaglutide	13,523,981	3,281,179	42
49	Famotidine	13,156,330	4,182,077	8
50	Estradiol	12,622,775	3,300,902	10
51	Diclofenac	12,480,262	4,295,892	10
52	Spironolactone	12,450,600	3,229,839	2
53	Hydrochlorothiazide; Lisinopril	12,335,355	2,917,147	2
54	Buspirone	12,332,589	2,671,839	1
55	Tramadol	12,203,197	4,050,454	14
56	Empagliflozin	12,009,951	3,063,605	29
57	Clonazepam	11,711,065	1,968,091	11
58	Lamotrigine	11,704,668	1,880,284	8
59	Fluticasone; Salmeterol	11,570,693	3,163,220	5
60	Oxycodone	11,314,082	4,797,946	1
61	Ondansetron	10,880,346	5,755,033	18
62	Cholecalciferol	10,833,991	3,330,178	3
63	Atenolol	10,675,235	2,625,632	16
64	Glimepiride	10,407,351	2,285,854	10
65	Folic Acid	10,185,562	2,602,156	12
66	Zolpidem	9,972,232	1,983,061	3
67	Latanoprost	9,971,002	2,723,057	1
68	Doxycycline	9,833,973	5,787,510	14
69	Lisdexamfetamine	9,791,955	1,529,700	0
70	Insulin Lispro	9,647,313	2,183,803	15
71	Clonidine	9,626,080	1,877,700	9
72	Loratadine	9,230,347	2,593,104	5
73	Finasteride	9,203,008	2,626,865	15
74	Dulaglutide	8,968,874	2,001,700	4
75	Hydrochlorothiazide; Losartan	8,825,878	2,442,356	12
76	Insulin Aspart	8,813,259	1,733,883	5
77	Propranolol	8,810,846	2,153,812	14
78	Azithromycin	8,770,185	7,146,386	19
79	Ezetimibe	8,656,499	2,228,797	13
80	Ethinyl Estradiol; Norethindrone	8,582,372	2,406,285	28
81	Lorazepam	8,502,480	2,170,621	3
82	Quetiapine	8,443,014	1,585,405	20
83	Budesonide; Formoterol	8,225,092	1,875,357	11
84	Topiramate	8,210,654	1,983,577	18
85	Warfarin	8,135,552	1,602,377	29
86	Sitagliptin	7,947,929	1,739,317	3
87	Amitriptyline	7,887,977	1,675,744	20
88	Fenofibrate	7,816,415	1,955,538	7
89	Naproxen	7,381,940	3,270,262	4
90	Rivaroxaban	7,298,837	1,913,151	4
91	Pregabalin	7,167,540	1,601,090	18
92	Paroxetine	7,127,748	1,470,173	3
93	Celecoxib	7,023,511	2,410,924	5
94	Tizanidine	6,971,104	2,286,583	5
95	Sumatriptan	6,899,199	2,105,101	14
96	Amoxicillin; Clavulanate	6,874,603	5,534,480	19
97	Olmesartan	6,554,547	1,703,089	29
98	Acetaminophen; Oxycodone	6,531,255	2,280,831	23
99	Ethinyl Estradiol; Norgestimate	6,339,863	1,867,085	23
100	Diltiazem	6,257,580	1,785,422	16
101	Cephalexin	6,228,250	4,570,468	5
102	Triamcinolone	6,216,924	4,171,508	2
103	Alendronate	6,127,862	1,912,735	9
104	Baclofen	6,099,128	1,603,798	1
105	Mirtazapine	6,069,480	1,310,009	19
106	Aripiprazole	6,053,911	1,275,362	7
107	Ferrous Sulfate	6,042,033	2,327,497	2
108	Chlorthalidone	5,928,576	1,597,980	19
109	Dexmethylphenidate	5,809,075	727,981	12
110	Oxybutynin	5,781,797	1,749,942	8
111	Lovastatin	5,745,441	1,419,808	11
112	Hydroxychloroquine	5,566,988	1,214,358	4
113	Valacyclovir	5,529,292	2,563,195	1
114	Acetaminophen	5,512,120	2,703,476	1
115	Dapagliflozin	5,503,867	1,372,807	72
116	Hydrochlorothiazide; Triamterene	5,500,903	1,489,499	4
117	Valsartan	5,450,866	1,714,202	3
118	Testosterone	5,432,642	1,394,497	25
119	Isosorbide	5,429,185	1,322,047	8
120	Pioglitazone	5,389,600	1,162,718	9
121	Hydralazine	5,298,188	1,544,740	15
122	Esomeprazole	5,207,671	1,215,844	3
123	Levetiracetam	5,202,579	1,182,326	22
124	Azelastine	5,195,092	1,746,057	21
125	Progesterone	5,153,382	1,095,601	42
126	Methocarbamol	5,109,104	2,345,639	3
127	Insulin Detemir	4,867,207	905,394	10
128	Ethinyl Estradiol; Levonorgestrel	4,846,343	1,327,012	16
129	Meclizine	4,776,929	1,493,854	7
130	Benzonatate	4,735,583	3,264,685	28
131	Cyanocobalamin	4,663,173	1,489,713	21
132	Methotrexate	4,565,259	1,077,459	0
133	Metronidazole	4,493,311	2,696,460	61
134	Acyclovir	4,458,457	1,322,764	35
135	Norethindrone	4,337,336	1,420,212	5
136	Prednisolone	4,327,569	2,421,943	17
137	Thyroid	4,312,524	823,819	18
138	Insulin Degludec	4,306,212	903,028	8
139	Liraglutide	4,271,706	789,348	27
140	Morphine	4,101,413	799,046	16
141	Enalapril	4,066,367	906,186	137
142	Drospirenone; Ethinyl Estradiol	4,033,582	972,919	10
143	Sulfamethoxazole; Trimethoprim	3,932,844	2,772,821	21
144	Fluticasone; Umeclidinium; Vilanterol	3,919,607	827,181	29
145	Fluticasone; Vilanterol	3,879,209	945,692	37
146	Donepezil	3,855,535	1,015,233	15
147	Clindamycin	3,855,100	2,369,863	29
148	Docusate	3,801,797	1,558,611	15
149	Phentermine	3,738,423	1,030,978	58
150	Memantine	3,703,293	896,917	20
151	Nifedipine	3,681,537	1,138,199	23
152	Levocetirizine	3,646,727	973,836	38
153	Methylprednisolone	3,595,226	2,813,645	15
154	Tiotropium	3,585,223	916,849	20
155	Timolol	3,536,135	860,252	8
156	Clobetasol	3,528,926	1,930,537	6
157	Sildenafil	3,459,590	1,127,720	0
158	Nitrofurantoin	3,448,530	2,502,989	23
159	Benazepril	3,424,799	993,316	12
160	Fluconazole	3,398,872	2,006,839	5
161	Desogestrel; Ethinyl Estradiol	3,308,281	957,396	24
162	Mupirocin	3,302,563	2,396,124	41
163	Ropinirole	3,241,699	781,835	21
164	Nirmatrelvir; Ritonavir	3,240,848	2,965,795	0
165	Sacubitril; Valsartan	3,183,215	727,811	24
166	Acetaminophen; Codeine	3,179,641	1,402,706	10
167	Oxcarbazepine	3,138,991	623,643	37
168	Cefdinir	3,098,850	2,412,211	29
169	Diazepam	3,093,210	1,011,956	20
170	Amlodipine; Benazepril	3,083,302	839,349	20
171	Olanzapine	3,028,056	443,521	7
172	Tadalafil	3,024,680	709,112	1
173	Nebivolol	3,006,294	724,281	71
174	Valproate	2,969,360	553,891	19
175	Ketoconazole	2,955,996	1,496,073	14
176	Dicyclomine	2,924,051	1,008,828	28
177	Budesonide	2,800,249	864,807	8
178	Albuterol; Ipratropium	2,771,010	794,788	27
179	Anastrozole	2,676,294	623,266	3
180	Doxazosin	2,644,458	659,808	15
181	Ciprofloxacin	2,622,220	1,994,293	40
182	Metformin; Sitagliptin	2,611,967	597,745	28
183	Risperidone	2,609,294	536,202	45
184	Torsemide	2,524,293	631,189	4
185	Cyclosporine	2,478,714	864,942	10
186	Dexlansoprazole	2,454,438	674,083	0
187	Ramipril	2,404,446	558,392	14
188	Verapamil	2,384,033	642,398	8
189	Linaclotide	2,378,887	534,890	57
190	Rizatriptan	2,297,918	588,662	31
191	Nortriptyline	2,256,836	647,355	52
192	Insulin Human; Insulin Isophane Human	2,234,041	447,324	13
193	Pramipexole	2,224,945	654,960	16
194	Ethinyl Estradiol; Etonogestrel	2,217,838	604,521	4
195	Bimatoprost	2,197,512	520,908	9
196	Nitroglycerin	2,158,295	1,227,621	22
197	Colchicine	2,153,766	923,806	13
198	Promethazine	2,149,358	857,334	10
199	Brimonidine	2,126,110	692,801	39
200	Irbesartan	2,067,518	566,827	28

Showing 1 to 200 of 200 entries

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Jan 1, 2024

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