Drug Usage Statistics, United States, 2013 - 2021

Lamotrigine Summary for 2021

Top drug rank #50 ( 12)
Estimated number of prescriptions in the United States (2021) 13,244,443
Estimated number of patients in the United States (2021) 1,957,025
Average total drug cost (USD)  
Per prescription $84.63
Per day of therapy $1.89/day
Average out-of-pocket cost (USD)  
Per prescription $12.08
Per day of therapy $0.22/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 82  13
2014 68  14
2015 70  2
2016 70 0
Year Rank Change
2017 63  7
2018 68  5
2019 71  3
2020 62  9
2021 50  12

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 200 mg 28.7%
Tablet/capsule 100 mg 27.8%
Tablet/capsule 25 mg 19.2%
Tablet/capsule 150 mg 17.0%
Tablet/capsule 250 mg 5.6%
Other, unspecified, or misc. 1.7%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Gabapentin 47,125,974
Lamotrigine (this drug) 13,244,443
Oxcarbazepine 4,492,393
Valproate 3,633,026

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Lamictal
  • Lamictal CD
  • Lamictal Odt
  • Lamictal XR
Generic Drug Synonyms and Salts
  • Lamotrigine

FDA Approval Information

Established Pharmacologic Class (EPC): Anti-epileptic Agent, Mood Stabilizer
Initial FDA approval date: 12/27/1994
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Which of these drugs is contraindicated in pregnancy? The Top 250 Drugs by ClinCalc Academy
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Updated Sep 12, 2021
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