Hydrochlorothiazide; Losartan

Drug Usage Statistics, United States, 2013 - 2019

Hydrochlorothiazide; Losartan Summary for 2019

Top drug rank #73 ( 19)
Estimated number of prescriptions in the United States (2019) 10,268,139
Estimated number of patients in the United States (2019) 2,318,012
Average total drug cost (USD)  
Per prescription $52.33
Per day of therapy $1.10/day
Average out-of-pocket cost (USD)  
Per prescription $7.92
Per day of therapy $0.18/day

Total Prescriptions and Patients Per Year (2013 - 2019)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 62  14
2014 61  1
2015 59  2
2016 79  20
Year Rank Change
2017 67  12
2018 54  13
2019 73  19

Drug Cost Over Time (2013 - 2019)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2019)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 100-25 mg 100.0%

Distribution of Days Supplied (2019)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2019)
Losartan 51,773,869
Hydrochlorothiazide 38,609,803
Hydrochlorothiazide; Lisinopril 15,709,833
Hydrochlorothiazide; Losartan (this drug) 10,268,139
Triamterene; Hydrochlorothiazide 5,792,731
Valsartan 4,158,667
Olmesartan 3,742,012
Irbesartan 3,220,533
Sacubitril; Valsartan 2,165,813
Valsartan; Hydrochlorothiazide 1,993,867
Telmisartan 1,553,265
Bisoprolol; Hydrochlorothiazide 1,433,172
Benazepril; Hydrochlorothiazide 971,361
Hydrochlorothiazide; Olmesartan 908,317

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Hyzaar
  • Losartan Potassium And Hydrochlorothiazide
Generic Drug Synonyms and Salts
  • Hydrochlorothiazide; Losartan Potassium
  • Losartan Potassium; Hydrochlorothiazide
  • Hydrochlorothiazide; Losartan

FDA Approval Information

Established Pharmacologic Class (EPC): Angiotensin 2 Receptor Blocker, Thiazide Diuretic
Initial FDA approval date: 4/28/1995
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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