Hydrochlorothiazide; Lisinopril

Drug Usage Statistics, United States, 2006 - 2016

Number of Prescriptions Over Time (2006 - 2016)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2006 49  15
2007 44  5
2008 44 0
2009 30  14
2010 41  11
2011 39  2
Year Rank Change
2012 35  4
2013 26  9
2014 37  11
2015 37 0
2016 53  16

Patient Out-Of-Pocket Cost Over Time (2006 - 2016)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2016)
Lisinopril 110,611,325
Hydrochlorothiazide 43,472,270
Hydrochlorothiazide; Lisinopril (this drug) 14,862,224
Hydrochlorothiazide; Triamterene 12,735,627
Hydrochlorothiazide; Losartan Potassium 9,772,429
Enalapril Maleate 8,342,017
Benazepril Hydrochloride 7,093,458
Hydrochlorothiazide; Valsartan 5,000,778
Amlodipine Besylate; Benazepril Hydrochloride 4,829,729
Ramipril 4,206,514
Quinapril 2,610,035
Bisoprolol Fumarate; Hydrochlorothiazide 1,114,559
Hydrochlorothiazide; Telmisartan 1,008,022

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Lisinopril And Hydrochlorothiazide
  • Prinzide
  • Zestoretic
Generic Drug Synonyms and Salts
  • Lisinopril; Hydrochlorothiazide
  • Hydrochlorothiazide; Lisinopril

FDA Approval Information

Established Pharmacologic Class (EPC): Thiazide Diuretic, Angiotensin Converting Enzyme Inhibitor
Initial FDA approval date: 2/16/1989
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2006-2016. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 19.1. Read more about the ClinCalc DrugStats database.


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Which of these drugs causes acute kidney injury? The Top 250 Drugs by ClinCalc Academy
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Updated Jul 19, 2018
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