Acetaminophen; Codeine

Drug Usage Statistics, United States, 2013 - 2020

Acetaminophen; Codeine Summary for 2020

Top drug rank #187 ( 14)
Estimated number of prescriptions in the United States (2020) 2,791,617
Estimated number of patients in the United States (2020) 1,314,846
Average total drug cost (USD)  
Per prescription $18.65
Per day of therapy $1.76/day
Average out-of-pocket cost (USD)  
Per prescription $4.39
Per day of therapy $0.71/day

Total Prescriptions and Patients Per Year (2013 - 2020)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 95  1
2014 99  4
2015 96  3
2016 120  24
Year Rank Change
2017 131  11
2018 150  19
2019 173  23
2020 187  14

Drug Cost Over Time (2013 - 2020)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2020)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 30/300 mg/mg 85.7%
Tablet/capsule 300/30 mg/mg 7.1%
Tablet/capsule 30-300 mg/mg 7.1%
Other, unspecified, or misc. 0.1%

Distribution of Days Supplied (2020)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2020)
Acetaminophen; Hydrocodone 30,100,356
Tramadol 17,475,420
Oxycodone 12,289,519
Acetaminophen; Oxycodone 10,086,467
Morphine 4,384,337
Acetaminophen; Codeine (this drug) 2,791,618
Hydromorphone 1,747,152
Loperamide 799,680
Codeine; Guaifenesin 415,672
Homatropine; Hydrocodone 49,346
Chlorpheniramine; Hydrocodone 13,840

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Acetaminophen And Codeine Phosphate
  • Capital And Codeine
  • Codrix
  • Empracet W/ Codeine Phosphate #3
  • Empracet W/ Codeine Phosphate #4
  • Papa-deine #3
  • Papa-deine #4
  • Phenaphen W/ Codeine NO. 2
  • Phenaphen W/ Codeine NO. 3
  • Phenaphen W/ Codeine NO. 4
  • Phenaphen-650 W/ Codeine
  • Proval #3
  • Tylenol W/ Codeine
  • Tylenol W/ Codeine NO. 1
  • Tylenol W/ Codeine NO. 2
  • Tylenol W/ Codeine NO. 3
  • Tylenol W/ Codeine NO. 4
  • Acetaminophen And Codeine
Generic Drug Synonyms and Salts
  • Acetaminophen; Codeine Phosphate
  • Codeine Phosphate; Acetaminophen
  • Acetaminophen; Codeine

FDA Approval Information

Established Pharmacologic Class (EPC): Opioid Agonist
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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