The Top 200 of 2019

Provided by the ClinCalc DrugStats Database

The Top 200 Drugs of 2019

Rank Drug Name Total Prescriptions (2019) Total Patients (2019) Annual Change
1 Atorvastatin 112,104,359 24,493,971 0
2 Levothyroxine 102,595,103 19,698,087 0
3 Lisinopril 91,862,708 19,990,170 0
4 Metformin 85,739,443 17,430,765 0
5 Metoprolol 74,578,817 15,177,787  1
6 Amlodipine 73,542,114 16,419,181  1
7 Albuterol 60,679,987 19,085,418 0
8 Omeprazole 52,546,641 12,869,290 0
9 Losartan 51,773,869 11,760,646 0
10 Gabapentin 47,149,505 9,818,634  1
11 Hydrochlorothiazide 38,609,803 9,358,879  2
12 Sertraline 37,157,933 7,723,122  2
13 Simvastatin 36,812,966 8,543,612  3
14 Montelukast 32,154,358 7,429,725  1
15 Acetaminophen; Hydrocodone 30,355,778 10,409,764  3
16 Pantoprazole 28,880,217 6,777,996  2
17 Furosemide 28,352,226 6,640,042 0
18 Fluticasone 27,893,102 9,564,147  1
19 Escitalopram 27,510,958 6,016,820  2
20 Fluoxetine 27,110,302 5,143,421  2
21 Rosuvastatin 27,041,319 6,129,254  7
22 Bupropion 25,722,873 5,520,278  5
23 Amoxicillin 25,702,634 20,368,921  7
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 24,600,698 3,576,687 0
25 Trazodone 23,934,213 5,066,449  5
26 Duloxetine 23,821,965 4,296,613  9
27 Prednisone 22,889,929 10,999,246  7
28 Tamsulosin 21,934,065 5,309,654  3
29 Ibuprofen 21,746,702 10,951,995  3
30 Citalopram 21,546,700 4,050,776  4
31 Meloxicam 21,459,849 6,484,210  2
32 Pravastatin 20,683,277 4,875,694  3
33 Carvedilol 20,602,256 4,553,133  1
34 Potassium 20,001,670 4,589,222  5
35 Tramadol 19,838,715 5,496,843  10
36 Clopidogrel 19,447,746 4,256,662  1
37 Insulin Glargine 19,211,653 3,708,654  14
38 Aspirin 18,143,138 4,646,616 0
39 Atenolol 18,091,488 3,788,125  2
40 Venlafaxine 17,713,653 3,035,802  9
41 Alprazolam 17,533,262 3,925,013  5
42 Ethinyl Estradiol; Norethindrone 16,505,642 3,462,531  15
43 Allopurinol 15,900,788 3,637,367  5
44 Hydrochlorothiazide; Lisinopril 15,709,833 3,277,894  6
45 Cyclobenzaprine 15,597,385 5,379,870  3
46 Clonazepam 15,578,495 2,347,398 0
47 Zolpidem 15,419,648 3,013,103  13
48 Azithromycin 15,300,433 11,577,286  3
49 Oxycodone 14,669,103 4,730,687  2
50 Warfarin 14,632,370 2,789,155  1
51 Methylphenidate 14,233,405 2,173,470  7
52 Apixaban 14,042,889 3,037,557  13
53 Ranitidine 13,586,751 3,781,812  13
54 Glipizide 13,424,610 2,939,354  11
55 Ergocalciferol 13,273,652 4,124,239  6
56 Quetiapine 13,114,560 1,966,742  3
57 Budesonide; Formoterol 12,473,902 2,754,790  5
58 Estradiol 12,393,425 2,860,475  2
59 Acetaminophen; Oxycodone 11,962,650 3,850,554  6
60 Ondansetron 11,856,066 5,284,836  4
61 Naproxen 11,762,233 4,575,857  6
62 Glimepiride 11,504,531 2,277,208  8
63 Spironolactone 11,432,027 2,985,578 0
64 Clonidine 11,418,367 2,178,697  9
65 Insulin Lispro 11,389,229 2,433,328  28
66 Loratadine 11,374,226 3,311,472  9
67 Cetirizine 11,110,560 3,439,020  12
68 Topiramate 10,927,224 2,035,700  23
69 Lorazepam 10,875,212 2,837,061  11
70 Ethinyl Estradiol; Norgestimate 10,860,083 2,372,165  10
71 Lamotrigine 10,690,317 1,818,670  3
72 Diltiazem 10,604,813 2,159,158  4
73 Hydrochlorothiazide; Losartan 10,268,139 2,318,012  19
74 Diclofenac 10,115,975 4,025,423  7
75 Hydroxyzine 9,898,263 2,977,526  2
76 Buspirone 9,881,603 2,172,778  19
77 Latanoprost 9,800,569 2,454,924  7
78 Paroxetine 9,783,755 2,043,795  6
79 Lisdexamfetamine 9,775,262 1,485,285  3
80 Fluticasone; Salmeterol 9,762,036 2,315,744  14
81 Pregabalin 9,625,189 1,731,352  12
82 Propranolol 9,277,061 2,421,089  30
83 Cephalexin 9,246,463 6,267,878  2
84 Cholecalciferol 9,068,152 2,424,272  15
85 Insulin Aspart 9,067,406 1,854,475  11
86 Finasteride 8,986,897 2,314,978  2
87 Fenofibrate 8,970,219 2,057,889  16
88 Sitagliptin 8,866,811 1,649,524  5
89 Folic Acid 8,860,645 2,096,607  18
90 Doxycycline 8,809,374 5,335,777  11
91 Rivaroxaban 8,799,404 1,988,539  11
92 Tizanidine 8,729,694 2,243,428  5
93 Amoxicillin; Clavulanate 8,372,244 6,468,086  1
94 Amitriptyline 8,178,156 1,861,683  16
95 Lovastatin 8,091,735 1,897,500  5
96 Alendronate 7,811,899 2,010,715  10
97 Levetiracetam 7,560,850 1,443,028  1
98 Sumatriptan 7,050,329 1,839,891  14
99 Hydralazine 6,655,156 1,694,706  1
100 Sulfamethoxazole; Trimethoprim 6,630,866 4,339,439  6
101 Aripiprazole 6,625,791 1,370,773  2
102 Celecoxib 6,595,236 1,905,201  29
103 Ferrous Sulfate 6,417,568 2,135,927  14
104 Famotidine 6,355,768 2,287,703  11
105 Benzonatate 6,354,434 3,974,773  9
106 Mirtazapine 6,332,488 1,231,211  5
107 Triamcinolone 6,320,751 4,026,933  1
108 Ezetimibe 6,221,674 1,427,468  21
109 Fluticasone; Vilanterol 6,098,161 1,248,072  11
110 Valacyclovir 5,987,835 2,824,569  34
111 Methotrexate 5,937,198 1,082,328  17
112 Oxybutynin 5,901,953 1,476,858  8
113 Ciprofloxacin 5,878,441 4,027,141  6
114 Valproate 5,824,937 910,407  21
115 Triamterene; Hydrochlorothiazide 5,792,730 1,313,745  3
116 Thyroid 5,729,895 1,015,144  7
117 Diazepam 5,711,206 1,600,062  1
118 Nifedipine 5,638,841 1,235,265  6
119 Clindamycin 5,588,597 3,047,976  17
120 Donepezil 5,538,291 1,432,688  14
121 Insulin Detemir 5,534,526 1,114,545  8
122 Hydroxychloroquine 5,440,844 1,220,122  11
123 Isosorbide 5,420,352 1,196,717  12
124 Ethinyl Estradiol; Levonorgestrel 5,372,880 1,462,023  14
125 Baclofen 5,366,102 1,428,051 0
126 Testosterone 5,339,785 1,225,167  1
127 Esomeprazole 5,305,918 1,296,630  22
128 Desogestrel; Ethinyl Estradiol 5,264,389 1,110,114  44
129 Oseltamivir 5,214,926 4,417,445  33
130 Benazepril 5,180,063 1,334,128  9
131 Dexmethylphenidate 5,179,401 714,477  29
132 Tiotropium 5,177,802 1,174,965  22
133 Fluconazole 5,149,547 3,048,599  3
134 Dulaglutide 5,095,034 1,115,444  20
135 Chlorthalidone 4,986,853 1,195,004  29
136 Methocarbamol 4,888,933 1,764,142  13
137 Enalapril 4,669,056 958,638  3
138 Metronidazole 4,664,907 2,898,583  16
139 Prednisolone 4,638,327 2,547,930 0
140 Guanfacine 4,608,026 690,784  8
141 Verapamil 4,593,421 927,301  8
142 Liraglutide 4,524,862 973,972  5
143 Norethindrone 4,514,574 1,096,191  1
144 Ropinirole 4,487,533 997,625  27
145 Acetaminophen 4,483,857 2,536,254  59
146 Empagliflozin 4,459,539 914,424  70
147 Hydrocortisone 4,382,981 2,143,789  1
148 Drospirenone; Ethinyl Estradiol 4,348,309 943,259  20
149 Risperidone 4,285,907 663,688  12
150 Meclizine 4,258,968 1,439,405  7
151 Albuterol; Ipratropium 4,231,364 1,046,066  6
152 Adalimumab 4,208,358 553,816  27
153 Nortriptyline 4,190,832 788,683  1
154 Valsartan 4,158,666 1,072,224  57
155 Cyanocobalamin 4,061,263 1,191,271  29
156 Etonogestrel; Ethinyl Estradiol 4,050,295 834,116  11
157 Acyclovir 3,950,520 1,308,357  1
158 Phentermine 3,842,226 1,017,109  11
159 Cefdinir 3,839,266 3,008,107  8
160 Timolol 3,833,125 1,052,388  7
161 Methylprednisolone 3,812,202 2,834,344  4
162 Oxcarbazepine 3,796,002 632,006 0
163 Morphine 3,756,696 636,123  26
164 Olmesartan 3,742,011 1,000,776  78
165 Dicyclomine 3,730,730 1,156,286  32
166 Pramipexole 3,685,677 735,018  32
167 Azelastine 3,669,768 1,247,976  56
168 Insulin Degludec 3,632,525 773,441  18
169 Memantine 3,631,969 831,395  22
170 Prazosin 3,624,710 616,417  39
171 Ketoconazole 3,573,982 1,796,305  16
172 Rizatriptan 3,514,594 857,676  2
173 Acetaminophen; Codeine 3,508,582 1,971,731  23
174 Promethazine 3,392,438 1,547,216  19
175 Metformin; Sitagliptin 3,363,543 668,951  17
176 Anastrozole 3,338,664 811,943  56
177 Desvenlafaxine 3,283,561 590,830  36
178 Ramipril 3,271,102 853,882  19
179 Pioglitazone 3,241,839 858,233  38
180 Clobetasol 3,226,423 1,688,723  35
181 Irbesartan 3,220,533 896,653  6
182 Levofloxacin 3,202,649 1,995,684  19
183 Amiodarone 3,185,474 714,249  7
184 Nitroglycerin 3,165,204 1,274,921  4
185 Olanzapine 3,165,180 528,975  42
186 Sucralfate 3,161,187 892,843  16
187 Docusate 3,136,752 1,377,989  41
188 Progesterone 3,070,724 722,137  15
189 Mirabegron 3,065,676 742,152  46
190 Mupirocin 3,064,118 2,172,326  24
191 Nebivolol 3,061,887 667,364  8
192 Nitrofurantoin 2,957,359 1,608,563  12
193 Levocetirizine 2,913,554 805,527  35
194 Methimazole 2,901,300 544,953  49
195 Cyclosporine 2,889,776 904,132  34
196 Sildenafil 2,877,293 973,315  12
197 Carbamazepine 2,864,887 478,023  8
198 Labetalol 2,825,281 653,627  33
199 Calcium; Cholecalciferol 2,777,842 621,965  29
200 Lansoprazole 2,772,218 632,804  17

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2019 calendar year), MEPS releasing the data from patients (August 2021), and the ClinCalc DrugStats release (a few months later, classified as the 2019 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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