The Top 200 of 2021

Provided by the ClinCalc DrugStats Database

The Top 200 Drugs of 2021

Rank Drug Name Total Prescriptions (2021) Total Patients (2021) Annual Change
1 Atorvastatin 116,702,335 28,111,470 0
2 Metformin 91,151,043 19,883,763  1
3 Levothyroxine 89,309,050 19,064,382  1
4 Lisinopril 88,272,557 20,475,892 0
5 Amlodipine 73,569,606 17,734,288 0
6 Metoprolol 65,529,551 15,535,072 0
7 Albuterol 61,469,064 18,070,429 0
8 Losartan 55,245,074 13,363,279  1
9 Omeprazole 54,561,969 13,900,115  1
10 Gabapentin 47,125,973 10,697,239 0
11 Sertraline 39,206,397 8,478,900  1
12 Hydrochlorothiazide 39,038,822 9,665,980  1
13 Rosuvastatin 32,632,145 8,006,428  4
14 Montelukast 30,996,712 7,119,519 0
15 Escitalopram 30,505,719 6,499,379 0
16 Simvastatin 30,492,289 7,839,909  3
17 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 30,371,088 3,990,803  5
18 Bupropion 29,099,445 6,412,363 0
19 Pantoprazole 27,347,488 7,310,342  1
20 Acetaminophen; Hydrocodone 26,599,439 8,616,204  4
21 Furosemide 26,376,404 6,473,988  2
22 Trazodone 26,310,083 5,322,910  1
23 Fluticasone 25,283,015 7,859,173 0
24 Tamsulosin 23,540,060 6,474,672 0
25 Fluoxetine 22,686,838 4,764,311 0
26 Carvedilol 21,782,177 5,039,099 0
27 Duloxetine 20,012,841 4,444,533 0
28 Prednisone 19,898,457 8,660,906  2
29 Insulin Glargine 19,873,255 3,901,230  3
30 Potassium Chloride 18,543,551 4,479,822  3
31 Citalopram 18,444,405 4,126,597 0
32 Meloxicam 18,226,904 5,819,321  4
33 Apixaban 17,933,195 4,021,147  15
34 Aspirin 17,686,612 5,286,487  2
35 Ergocalciferol 17,179,725 5,191,630  11
36 Ibuprofen 17,043,550 8,701,817  2
37 Clopidogrel 16,723,608 4,187,295  8
38 Amoxicillin 16,657,138 13,130,571  2
39 Pravastatin 15,936,065 3,917,270  5
40 Allopurinol 15,706,780 3,768,723  2
41 Tramadol 15,446,495 5,026,719  6
42 Alprazolam 15,380,320 3,325,555  5
43 Methylphenidate 15,282,088 2,440,779  2
44 Venlafaxine 15,122,966 3,008,776  1
45 Cyclobenzaprine 14,426,039 5,107,046  6
46 Clonazepam 14,197,547 2,352,995  2
47 Atenolol 14,107,487 3,384,297  6
48 Glipizide 13,998,178 3,402,458  1
49 Cetirizine 13,929,421 4,000,093  3
50 Lamotrigine 13,244,443 1,957,025  12
51 Hydrochlorothiazide; Lisinopril 12,908,559 3,026,424  1
52 Ethinyl Estradiol; Norethindrone 12,906,438 2,753,719  7
53 Buspirone 12,694,068 2,644,397  2
54 Spironolactone 12,688,242 3,146,100  3
55 Insulin Lispro 12,035,959 2,270,527  16
56 Warfarin 11,785,098 2,244,265  2
57 Famotidine 11,668,047 3,867,415  9
58 Hydroxyzine 11,643,508 3,392,983  12
59 Oxycodone 11,552,448 4,150,118  5
60 Estradiol 11,382,723 2,864,047  1
61 Diclofenac 11,037,695 4,112,922  11
62 Quetiapine 10,957,922 1,809,254  2
63 Zolpidem 10,838,845 2,402,662  16
64 Fluticasone; Salmeterol 10,678,059 2,794,066  8
65 Cholecalciferol 10,583,900 3,367,693  5
66 Topiramate 10,042,403 2,069,817  9
67 Loratadine 9,990,364 2,515,720  6
68 Latanoprost 9,895,398 2,753,023  9
69 Lisdexamfetamine 9,835,531 1,450,419  16
70 Dulaglutide 9,599,734 1,926,282  26
71 Insulin Aspart 9,568,330 2,082,384  9
72 Budesonide; Formoterol 9,505,098 2,322,938  11
73 Pregabalin 8,996,019 1,687,032  5
74 Glimepiride 8,994,560 2,066,583  13
75 Acetaminophen; Oxycodone 8,987,786 2,612,150  6
76 Ethinyl Estradiol; Norgestimate 8,963,409 2,283,373  13
77 Folic Acid 8,892,870 2,343,374  10
78 Lorazepam 8,860,599 2,204,460  13
79 Ondansetron 8,790,270 4,741,786  4
80 Clonidine 8,613,722 1,835,614  5
81 Fenofibrate 8,600,833 2,043,475  14
82 Doxycycline 8,599,224 4,431,691  3
83 Sitagliptin 8,556,031 1,865,004  9
84 Diltiazem 8,522,821 2,091,547  8
85 Empagliflozin 8,480,340 2,159,608  17
86 Rivaroxaban 8,330,556 1,772,808 0
87 Hydrochlorothiazide; Losartan 8,266,619 2,268,307  6
88 Finasteride 8,254,453 2,480,881  2
89 Tizanidine 8,192,389 2,238,146  5
90 Semaglutide 8,153,559 1,959,322  39
91 Propranolol 7,993,156 2,008,047  3
92 Ezetimibe 7,646,574 2,047,338  8
93 Naproxen 7,592,556 3,530,473  2
94 Alendronate 7,482,354 2,145,965 0
95 Paroxetine 7,482,340 1,614,935  13
96 Cephalexin 7,322,464 4,945,408  5
97 Azithromycin 7,308,877 5,781,665  29
98 Celecoxib 7,082,350 1,967,573 0
99 Aripiprazole 6,805,675 1,400,604  10
100 Lovastatin 6,673,173 1,587,134  1
101 Levetiracetam 6,633,071 1,377,442  9
102 Oxybutynin 6,619,470 1,711,957  5
103 Baclofen 6,516,375 1,635,619  5
104 Triamcinolone 6,413,003 4,010,734  2
105 Ferrous Sulfate 6,320,872 2,164,663  11
106 Hydralazine 6,234,195 1,624,406  3
107 Amitriptyline 5,923,315 1,353,110  26
108 Fluticasone; Vilanterol 5,918,773 1,171,764  7
109 Sumatriptan 5,873,389 1,747,757  2
110 Cyanocobalamin 5,825,048 1,663,130  5
111 Isosorbide 5,601,959 1,436,412  3
112 Hydrochlorothiazide; Triamterene 5,428,906 1,392,875  19
113 Acetaminophen 5,327,155 2,796,327  5
114 Valacyclovir 5,268,219 2,165,806  5
115 Amoxicillin; Clavulanate 5,236,139 4,264,890  8
116 Hydroxychloroquine 5,222,102 1,329,229  10
117 Insulin Detemir 5,214,067 1,027,442  7
118 Clindamycin 5,194,038 2,949,885  7
119 Thyroid 5,159,236 1,012,361  2
120 Valsartan 5,151,116 1,457,484  3
121 Dexmethylphenidate 4,936,398 632,395  9
122 Sulfamethoxazole; Trimethoprim 4,905,134 3,199,276  1
123 Methocarbamol 4,798,559 1,797,747  4
124 Mirtazapine 4,752,292 1,063,153  20
125 Esomeprazole 4,673,931 1,068,821  3
126 Olmesartan 4,581,362 1,173,921  13
127 Chlorthalidone 4,577,162 1,281,201  6
128 Nifedipine 4,567,479 1,237,401  7
129 Pioglitazone 4,526,638 1,045,883  39
130 Oxcarbazepine 4,492,392 759,481  14
131 Donepezil 4,435,098 1,278,743  19
132 Methotrexate 4,402,317 912,086  19
133 Docusate 4,393,499 1,683,774  30
134 Tiotropium 4,361,799 975,405  24
135 Nitrofurantoin 4,327,699 2,493,318  32
136 Meclizine 4,269,435 1,648,602  6
137 Desogestrel; Ethinyl Estradiol 4,229,811 894,531  17
138 Risperidone 4,225,629 584,233 0
139 Nortriptyline 4,183,946 903,333  16
140 Norethindrone 4,164,058 1,311,480  3
141 Ciprofloxacin 4,147,677 2,735,003  9
142 Ropinirole 4,102,324 853,008  14
143 Testosterone 4,021,439 839,946  29
144 Ethinyl Estradiol; Levonorgestrel 4,016,121 1,376,728  15
145 Azelastine 4,011,208 1,350,513  28
146 Insulin Degludec 4,009,540 878,698  10
147 Benazepril 3,932,101 1,056,395  6
148 Dicyclomine 3,919,946 1,194,528  1
149 Diazepam 3,898,003 1,247,334  21
150 Amlodipine; Benazepril 3,883,604 933,017  19
151 Albuterol; Ipratropium 3,876,201 858,352  1
152 Drospirenone; Ethinyl Estradiol 3,875,387 859,872  7
153 Prednisolone 3,816,335 2,269,683 0
154 Metformin; Sitagliptin 3,755,407 784,043 0
155 Valproate 3,633,026 713,499  46
156 Morphine 3,629,439 704,840  16
157 Sildenafil 3,613,743 1,365,796  26
158 Benzonatate 3,569,507 2,046,763  1
159 Rizatriptan 3,505,154 886,004  25
160 Brimonidine 3,470,855 748,650  15
161 Ketoconazole 3,429,167 1,987,923  9
162 Clobetasol 3,428,139 1,849,660  9
163 Timolol 3,406,225 872,159  20
164 Olanzapine 3,347,385 600,079 0
165 Fluconazole 3,276,721 2,070,358  9
166 Liraglutide 3,264,900 784,141  20
167 Progesterone 3,257,570 804,553  9
168 Methylprednisolone 3,254,222 2,413,471  7
169 Acyclovir 3,250,033 1,058,857  7
170 Memantine 3,238,256 809,403  18
171 Tadalafil 3,167,761 757,242  90
172 Irbesartan 3,148,185 744,799  24
173 Fluticasone; Umeclidinium; Vilanterol 2,927,505 668,594  51
174 Nitroglycerin 2,842,773 1,169,220  9
175 Cyclosporine 2,802,769 871,693  37
176 Acetaminophen; Codeine 2,794,323 1,367,664  11
177 Gemfibrozil 2,791,706 635,078  12
178 Desvenlafaxine 2,781,884 534,265  2
179 Insulin Human; Insulin Isophane Human 2,768,890 557,473  67
180 Torsemide 2,753,009 530,362  33
181 Calcium Phosphate; Cholecalciferol 2,734,077 702,638  34
182 Anastrozole 2,728,845 573,970  2
183 Prazosin 2,692,449 512,048  7
184 Colchicine 2,646,595 963,808  57
185 Budesonide 2,617,796 858,977  22
186 Sucralfate 2,616,503 840,715  4
187 Dapagliflozin 2,607,169 715,994  30
188 Promethazine 2,595,247 965,521  20
189 Sacubitril; Valsartan 2,591,806 558,518  30
190 Levocetirizine 2,550,953 725,643  11
191 Dorzolamide; Timolol 2,518,853 788,637  4
192 Hydrocortisone 2,459,727 1,415,290  43
193 Lurasidone 2,433,438 385,353  66
194 Metronidazole 2,380,724 1,315,654  28
195 Doxazosin 2,340,070 593,551  14
196 Verapamil 2,339,847 580,801  45
197 Cefdinir 2,335,533 1,770,777  31
198 Ethinyl Estradiol; Etonogestrel 2,334,719 658,337  4
199 Liothyronine 2,325,739 478,880  19
200 Mirabegron 2,324,745 648,744  40

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2022 calendar year), MEPS releasing the data from patients (August 2024), and the ClinCalc DrugStats release (a few months later, classified as the 2022 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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