Drug Usage Statistics, United States, 2013 - 2021

Diclofenac Summary for 2021

Top drug rank #61 ( 11)
Estimated number of prescriptions in the United States (2021) 11,037,695
Estimated number of patients in the United States (2021) 4,112,922
Average total drug cost (USD)  
Per prescription $226.90
Per day of therapy $1.73/day
Average out-of-pocket cost (USD)  
Per prescription $14.14
Per day of therapy $0.37/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 73  7
2014 84  11
2015 84 0
2016 80  4
Year Rank Change
2017 101  21
2018 81  20
2019 74  7
2020 72  2
2021 61  11

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Gel 1% 45.4%
Tablet/capsule 75 mg 33.3%
Tablet/capsule 50 mg 13.7%
Other, unspecified, or misc. 7.6%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Meloxicam 18,226,904
Aspirin 17,686,612
Ibuprofen 17,043,551
Diclofenac (this drug) 11,037,695
Naproxen 7,592,556
Celecoxib 7,082,350
Ketorolac 2,124,922
Nabumetone 1,401,463
Indomethacin 1,374,643
Etodolac 456,118
Sulindac 337,904
Diclofenac; Misoprostol 126,293
Famotidine; Ibuprofen 111,801
Flurbiprofen 78,952
Piroxicam 20,466

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Zorvolex
  • Dyloject
  • Pennsaid
  • Solaraze
  • Voltaren
  • Voltaren Arthritis Pain
  • Voltaren-XR
  • Cambia
  • Cataflam
  • Zipsor
  • Flector
  • Licart
Generic Drug Synonyms and Salts
  • Diclofenac Epolamine
  • Diclofenac Potassium
  • Diclofenac Sodium
  • Diclofenac

FDA Approval Information

Established Pharmacologic Class (EPC): Nonsteroidal Anti-inflammatory Drug
Initial FDA approval date: 7/28/1988
First FDA applicant: Discn
First dosage form: Tablet, Delayed Release (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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