Drospirenone; Ethinyl Estradiol

Drug Usage Statistics, United States, 2014 - 2023

Drospirenone; Ethinyl Estradiol Summary for 2023

Top drug rank	#154 ( 12)
Estimated number of prescriptions in the United States (2023)	3,566,507
Estimated number of patients in the United States (2023)	880,241

Average total drug cost (USD)
Per prescription	$59.79
Per day of therapy	$1.52/day
Average out-of-pocket cost (USD)
Per prescription	$3.28
Per day of therapy	$0.20/day

Total Prescriptions and Patients Per Year (2014 - 2023)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2014	158	3
2015	137	21
2016	110	27
2017	96	14
2018	168	72

Year	Rank	Change
2019	148	20
2020	145	3
2021	152	7
2022	142	10
2023	154	12

Drug Cost Over Time (2014 - 2023)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2023)

Dosage Form	Strength	% of Dispensed Products
Tablet/capsule	3-0.02 mg	50.0%
Tablet/capsule	3/0.02 mg/mg	37.5%
Tablet/capsule	1-0.02 mg	12.5%

Distribution of Days Supplied (2023)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Kemeya
Kyra
LO-zumandimine
Loryna
Melamisa
Nikki
Syeda
Yaela
Yasmin
Yaz
Zumandimine

Generic Drug Synonyms and Salts

Drospirenone; Ethinyl Estradiol

FDA Approval Information

Established Pharmacologic Class (EPC):	N/A
Initial FDA approval date:	5/11/2001
First FDA applicant:	Rx
First dosage form:	Tablet (oral-28)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Apr 15, 2025

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Drospirenone; Ethinyl Estradiol

Drug Usage Statistics, United States, 2014 - 2023

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