Drug Usage Statistics, United States, 2013 - 2021

Hydrochlorothiazide Summary for 2021

Top drug rank #12 ( 1)
Estimated number of prescriptions in the United States (2021) 39,038,822
Estimated number of patients in the United States (2021) 9,665,980
Average total drug cost (USD)  
Per prescription $6.63
Per day of therapy $0.12/day
Average out-of-pocket cost (USD)  
Per prescription $2.76
Per day of therapy $0.05/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 10 0
2014 10 0
2015 11  1
2016 12  1
Year Rank Change
2017 12 0
2018 13  1
2019 11  2
2020 11 0
2021 12  1

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 25 mg 67.0%
Tablet/capsule 12.5 mg 29.7%
Other, unspecified, or misc. 3.3%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Hydrochlorothiazide (this drug) 39,038,823
Hydrochlorothiazide; Lisinopril 12,908,560
Hydrochlorothiazide; Losartan 8,266,619
Hydrochlorothiazide; Triamterene 5,428,907
Hydrochlorothiazide; Valsartan 1,871,393

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Esidrix
  • Hydro-d
  • Hydrochlorothiazide Intensol
  • Hydrodiuril
  • Microzide
  • Oretic
  • Zide
Generic Drug Synonyms and Salts
  • Hydrochlorothiazide

FDA Approval Information

Established Pharmacologic Class (EPC): Thiazide Diuretic
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


Related Links

Mailing List

New and Popular


Open Menu

Cite This Page

Show AMA citation

©2024 - ClinCalc LLC. All rights reserved.
Disclaimer - Privacy Policy - Contact Us
Updated Sep 12, 2021
Back to Top