Fluticasone; Salmeterol

Drug Usage Statistics, United States, 2013 - 2019

Fluticasone; Salmeterol Summary for 2019

Top drug rank #80 ( 14)
Estimated number of prescriptions in the United States (2019) 9,762,036
Estimated number of patients in the United States (2019) 2,315,744
Average total drug cost (USD)  
Per prescription $392.42
Per day of therapy $10.46/day
Average out-of-pocket cost (USD)  
Per prescription $39.11
Per day of therapy $1.09/day

Total Prescriptions and Patients Per Year (2013 - 2019)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 40  3
2014 49  9
2015 49 0
2016 62  13
Year Rank Change
2017 62 0
2018 66  4
2019 80  14

Drug Cost Over Time (2013 - 2019)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2019)

Dosage Form Strength % of Dispensed Products
Inhalation 250/50 mcg/mcg 52.5%
Inhalation 500 g 12.5%
Inhalation 500/50 mcg/mcg 12.5%
Inhalation 100/50 mcg/mcg 12.5%
Inhalation 250/50 mcg 10.0%

Distribution of Days Supplied (2019)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2019)
Albuterol 60,679,987
Fluticasone 27,893,103
Prednisone 22,889,929
Budesonide; Formoterol 12,473,903
Fluticasone; Salmeterol (this drug) 9,762,036
Triamcinolone 6,320,752
Fluticasone; Vilanterol 6,098,161
Prednisolone 4,638,327
Hydrocortisone 4,382,981
Albuterol; Ipratropium 4,231,365
Methylprednisolone 3,812,202
Clobetasol 3,226,424
Budesonide 2,749,946
Umeclidinium; Vilanterol 2,697,882
Beclomethasone 1,993,298
Mometasone 1,638,402
Tobramycin; Dexamethasone 1,486,152
Betamethasone 1,311,107
Fluocinonide 1,290,749
Levalbuterol 1,139,211
Olodaterol; Tiotropium 1,065,399
Neomycin; Polymyxin B; Hydrocortisone 978,292
Dexamethasone; Neomycin; Polymyxin B 957,525
Fluticasone; Umeclidinium; Vilanterol 936,336
Azelastine; Fluticasone 794,966
Formoterol; Mometasone 793,211
Dexamethasone 711,272
Betamethasone; Clotrimazole 631,823
Ciprofloxacin; Dexamethasone 515,590
Fluorometholone 434,532
Fluocinolone 313,716
Desonide 253,688

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Advair Diskus 100/50
  • Advair Diskus 250/50
  • Advair Diskus 500/50
  • Advair Hfa
  • Airduo Digihaler
  • Airduo Respiclick
  • Fluticasone Propionate And Salmeterol Xinafoate
  • Wixela Inhub
  • Advair
Generic Drug Synonyms and Salts
  • Fluticasone Propionate; Salmeterol Xinafoate
  • Salmeterol Xinafoate; Fluticasone Propionate
  • Fluticasone; Salmeterol

FDA Approval Information

Established Pharmacologic Class (EPC): Corticosteroid, beta2-Adrenergic Agonist
Initial FDA approval date: 8/24/2000
First FDA applicant: Rx
First dosage form: Powder (inhalation)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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