Sulfamethoxazole; Trimethoprim

Drug Usage Statistics, United States, 2013 - 2021

Sulfamethoxazole; Trimethoprim Summary for 2021

Top drug rank #122 ( 1)
Estimated number of prescriptions in the United States (2021) 4,905,134
Estimated number of patients in the United States (2021) 3,199,276
Average total drug cost (USD)  
Per prescription $11.28
Per day of therapy $1.18/day
Average out-of-pocket cost (USD)  
Per prescription $3.66
Per day of therapy $0.35/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 100  6
2014 111  11
2015 73  38
2016 105  32
Year Rank Change
2017 121  16
2018 94  27
2019 100  6
2020 121  21
2021 122  1

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 800 mg 87.5%
Tablet/capsule 800/160 mg 6.2%
Tablet/capsule 800/160 mg/mg 6.2%
Other, unspecified, or misc. 0.1%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Sulfamethoxazole; Trimethoprim (this drug) 4,905,135

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Bactrim
  • Bactrim DS
  • Bactrim Pediatric
  • Cotrim
  • Cotrim D.S.
  • Septra
  • Septra DS
  • Septra Grape
  • Sulfamethoprim
  • Sulfamethoprim-DS
  • Sulfamethoxazole And Trimethoprim
  • Sulfamethoxazole And Trimethoprim Double Strength
  • Sulfamethoxazole And Trimethoprim Single Strength
  • Sulfatrim
  • Sulfatrim Pediatric
  • Sulfatrim-DS
  • Sulfatrim-SS
  • Sulmeprim
  • Sulmeprim Pediatric
  • Trimeth/Sulfa
  • Uroplus DS
  • Uroplus SS
Generic Drug Synonyms and Salts
  • Trimethoprim; Sulfamethoxazole
  • Sulfamethoxazole; Trimethoprim

FDA Approval Information

Established Pharmacologic Class (EPC): Sulfonamide Antimicrobial, Dihydrofolate Reductase Inhibitor Antibacterial
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Injectable (injection)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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