Drug Usage Statistics, United States, 2006 - 2016

Number of Prescriptions Over Time (2006 - 2016)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2006 139  5
2007 139 0
2008 124  15
2009 123  1
2010 194  71
2011 216  22
Year Rank Change
2012 219  3
2013 192  27
2014 204  12
2015 250  46
2016 152  98

Patient Out-Of-Pocket Cost Over Time (2006 - 2016)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2016)
Methotrexate (this drug) 4,208,091

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Otrexup
  • Otrexup Pfs
  • Rasuvo
  • Abitrexate
  • Folex
  • Folex Pfs
  • Methotrexate Lpf
  • Methotrexate Preservative Free
  • Methotrexate Sodium Preservative Free
  • Mexate
  • Mexate-AQ
  • Mexate-AQ Preserved
  • Trexall
  • Xatmep
Generic Drug Synonyms and Salts
  • Methotrexate Sodium
  • Methotrexate

FDA Approval Information

Established Pharmacologic Class (EPC): Folate Analog Metabolic Inhibitor
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Injectable (injection)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2006-2016. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 19.1. Read more about the ClinCalc DrugStats database.


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Which of these drugs causes acute kidney injury? The Top 250 Drugs by ClinCalc Academy
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Updated Jul 19, 2018
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