Drug Usage Statistics, United States, 2006 - 2016

Number of Prescriptions Over Time (2006 - 2016)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2006 198  2
2007 216  18
2008 187  29
2009 232  45
2010 206  26
2011 196  10
Year Rank Change
2012 205  9
2013 198  7
2014 157  41
2015 164  7
2016 195  31

Patient Out-Of-Pocket Cost Over Time (2006 - 2016)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2016)
Valacyclovir 3,730,423
Acyclovir (this drug) 3,078,845

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Sitavig
  • Zovirax
  • Acyclovir
  • Acyclovir IN Sodium Chloride 0.9% Preservative Free
Generic Drug Synonyms and Salts
  • Acyclovir Sodium
  • Acyclovir

FDA Approval Information

Established Pharmacologic Class (EPC): Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor, Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor, Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
Initial FDA approval date: 3/29/1982
First FDA applicant: Rx
First dosage form: Ointment (topical)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2006-2016. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 19.1. Read more about the ClinCalc DrugStats database.


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Updated Jul 19, 2018
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