Drug Usage Statistics, United States, 2008 - 2018

Acyclovir Summary for 2018

Estimated number of prescriptions in the United States 4,170,803
Top drug rank #151 ( 15)
Average total drug cost $44.66 (USD)
Average out-of-pocket cost $7.09 (USD)

Number of Prescriptions Over Time (2008 - 2018)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2008 187  29
2009 232  45
2010 206  26
2011 197  9
2012 205  8
2013 198  7
Year Rank Change
2014 157  41
2015 164  7
2016 195  31
2017 166  29
2018 151  15

Drug Cost Over Time (2008 - 2018)

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Related Drugs

Drug Name Total Prescriptions (2018)
Valacyclovir 4,931,639
Acyclovir (this drug) 4,170,804

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Avaclyr
  • Sitavig
  • Zovirax
  • Acyclovir
  • Acyclovir IN Sodium Chloride 0.9% Preservative Free
Generic Drug Synonyms and Salts
  • Acyclovir Sodium
  • Acyclovir

FDA Approval Information

Established Pharmacologic Class (EPC): Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor, Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor, Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
Initial FDA approval date: 3/29/1982
First FDA applicant: Rx
First dosage form: Ointment (topical)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.1. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Jan 18, 2021
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