Ethinyl Estradiol; Norethindrone

Drug Usage Statistics, United States, 2014 - 2023

Ethinyl Estradiol; Norethindrone Summary for 2023

Top drug rank	#79 ( 1)
Estimated number of prescriptions in the United States (2023)	8,611,956
Estimated number of patients in the United States (2023)	2,206,708

Average total drug cost (USD)
Per prescription	$122.93
Per day of therapy	$2.76/day
Average out-of-pocket cost (USD)
Per prescription	$4.45
Per day of therapy	$0.10/day

Total Prescriptions and Patients Per Year (2014 - 2023)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2014	60	1
2015	60	0
2016	54	6
2017	52	2
2018	57	5

Year	Rank	Change
2019	42	15
2020	45	3
2021	52	7
2022	80	28
2023	79	1

Drug Cost Over Time (2014 - 2023)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2023)

No data available

Distribution of Days Supplied (2023)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2023)
Estradiol	11,289,113
Ethinyl Estradiol; Norethindrone (this drug)	8,611,957
Norethindrone	4,162,876
Ethinyl Estradiol; Levonorgestrel	4,052,883
Ethinyl Estradiol; Etonogestrel	2,987,624
Medroxyprogesterone	1,095,997
Ethinyl Estradiol; Norelgestromin	658,000

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Alyacen 1/35
Alyacen 7/7/7
Aranelle
Aurovela 1.5/30
Aurovela 1/20
Aurovela 24 FE
Aurovela FE 1.5/30
Aurovela FE 1/20
Balziva-21
Balziva-28
Blisovi 24 FE
Blisovi FE 1.5/30
Blisovi FE 1/20
Brevicon 21-day
Brevicon 28-day
Briellyn
Chabelina FE
Cyclafem 0.5/35
Cyclafem 1/35
Cyclafem 7/7/7
Cyonanz
Dasetta 1/35
Dasetta 7/7/7
Estrostep 21
Estrostep FE
Femcon FE
Femhrt
Femlyv
Finzala
Fyavolv
Gemmily
Gencept 10/11-21
Gencept 10/11-28
Gildagia
Gildess 1.5/30
Gildess 1/20
Gildess 24 FE
Gildess FE 1.5/30
Gildess FE 1/20
Hailey 1.5/30
Hailey 24 FE
Hailey FE 1.5/30
Hailey FE 1/20
Junel 1.5/30
Junel 1/20
Junel FE 1.5/30
Junel FE 1/20
Kaitlib FE
Larin 1.5/30
Larin 1/20
Larin 24 FE
Larin FE 1.5/30
Larin FE 1/20
Leribane
LO Loestrin FE
LO Minastrin FE
Loestrin 21 1.5/30
Loestrin 21 1/20
Loestrin 24 FE
Loestrin FE 1.5/30
Loestrin FE 1/20
Merzee
Mibelas 24 FE
Microgestin 1.5/30
Microgestin 1/20
Microgestin FE 1.5/30
Microgestin FE 1/20
Minastrin 24 FE
Modicon 21
Modicon 28
N.E.E. 1/35 21
N.E.E. 1/35 28
Nexesta FE
Norcept-e 1/35 21
Norcept-e 1/35 28
Norethin 1/35e-21
Norethin 1/35e-28
Norethindrone Acetate And Ethinyl Estradiol
Norethindrone Acetate And Ethinyl Estradiol And Ethinyl Estradiol And Ferrous Fumarate
Norethindrone Acetate And Ethinyl Estradiol And Ferrous Fumarate
Norethindrone And Ethinyl Estradiol
Norethindrone And Ethinyl Estradiol (10/11)
Norethindrone And Ethinyl Estradiol (7/14)
Norethindrone And Ethinyl Estradiol And Ferrous Fumarate
Norinyl 1+35 21-day
Norinyl 1+35 28-day
Norlestrin 21 1/50
Norlestrin 21 2.5/50
Norlestrin 28 1/50
Nortrel 0.5/35-21
Nortrel 0.5/35-28
Nortrel 1/35-21
Nortrel 1/35-28
Nortrel 7/7/7
Nylia 1/35
Nylia 7/7/7
Ortho-novum 1/35-21
Ortho-novum 1/35-28
Ortho-novum 10/11-21
Ortho-novum 10/11-28
Ortho-novum 7/14-21
Ortho-novum 7/14-28
Ortho-novum 7/7/7-21
Ortho-novum 7/7/7-28
Oshih
Ovcon-35
Ovcon-50
Philith
Pirmella 1/35
Pirmella 7/7/7
Rhuzdah
Taytulla
Tri-legest 21
Tri-legest FE
Tri-norinyl 21-day
Tri-norinyl 28-day
Vyfemla
Wera

Generic Drug Synonyms and Salts

Ethinyl Estradiol; Norethindrone Acetate
Norethindrone Acetate; Ethinyl Estradiol
Norethindrone; Ethinyl Estradiol
Ethinyl Estradiol; Norethindrone

FDA Approval Information

Established Pharmacologic Class (EPC):	Estrogen, Progestin
Initial FDA approval date:	Prior to January 1, 1982
First FDA applicant:	Discn
First dosage form:	Tablet (oral-28)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Apr 15, 2025

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Ethinyl Estradiol; Norethindrone

Drug Usage Statistics, United States, 2014 - 2023

ClinCalc.com » Pharmacy » ClinCalc DrugStats » Ethinyl Estradiol; Norethindrone