The Top 300 of 2021

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Annual Change
1 Atorvastatin 112,474,023  1
2 Lisinopril 97,608,879  1
3 Metformin Hydrochloride 83,762,981  1
4 Amlodipine 75,811,947  1
5 Metoprolol 71,581,961  1
6 Albuterol 60,526,457  4
7 Omeprazole 58,364,556 0
8 Losartan Potassium 50,479,750  1
9 Simvastatin 48,007,043  1
10 Gabapentin 45,586,654  1
11 Acetaminophen; Hydrocodone Bitartrate 42,073,176  2
12 Hydrochlorothiazide 40,575,075 0
13 Sertraline Hydrochloride 38,383,042  1
14 Montelukast 35,222,630  2
15 Fluticasone 34,253,764 0
16 Amoxicillin 31,371,675  2
17 Furosemide 29,857,945 0
18 Pantoprazole Sodium 28,958,134  1
19 Acetaminophen 27,907,360  6
20 Prednisone 27,057,494  2
21 Escitalopram Oxalate 25,978,773  1
22 Fluoxetine Hydrochloride 25,619,277  9
23 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775  4
24 Tramadol Hydrochloride 24,952,328  8
25 Insulin Glargine 24,911,721  8
26 Bupropion 24,488,843  3
27 Ibuprofen 24,453,501  1
28 Rosuvastatin 24,138,061  11
29 Pravastatin Sodium 24,022,031  5
30 Trazodone Hydrochloride 23,889,624 0
31 Tamsulosin Hydrochloride 23,254,004  4
32 Carvedilol 22,737,638  3
33 Meloxicam 22,610,690  5
34 Citalopram 22,224,263  8
35 Duloxetine 21,217,653  11
36 Alprazolam 20,843,479  15
37 Clopidogrel Bisulfate 20,016,095  3
38 Aspirin 19,750,180  4
39 Ranitidine 18,739,686  9
40 Atenolol 18,644,884  4
41 Cyclobenzaprine 18,041,836  2
42 Glipizide 17,549,602  3
43 Methylphenidate 17,467,265  4
44 Azithromycin 17,102,628  13
45 Clonazepam 17,064,643  11
46 Oxycodone 16,967,479  6
47 Allopurinol 16,374,431  7
48 Venlafaxine 16,121,149  1
49 Hydrochlorothiazide; Lisinopril 15,932,877  5
50 Warfarin 14,772,355  1
51 Propranolol Hydrochloride 14,571,767  10
52 Hydrochlorothiazide; Losartan Potassium 13,880,262  15
53 Cetirizine 13,799,351  13
54 Estradiol 13,583,025  7
55 Ethinyl Estradiol; Norethindrone 13,509,602  2
56 Lorazepam 13,222,989  4
57 Quetiapine Fumarate 12,962,563  19
58 Zolpidem Tartrate 12,877,940  8
59 Ergocalciferol 12,831,209  4
60 Budesonide; Formoterol 12,339,319  14
61 Spironolactone 12,260,624  8
62 Ondansetron 12,240,225  21
63 Insulin Aspart 12,146,568  7
64 Apixaban 12,113,153  29
65 Naproxen 11,942,765  6
66 Lamotrigine 11,582,775  3
67 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537  2
68 Pregabalin 11,429,654  4
69 Glimepiride 11,405,689  5
70 Diclofenac 11,372,069  24
71 Fenofibrate 11,325,402  1
72 Paroxetine 11,228,908  4
73 Clonidine 11,141,934  6
74 Loratadine 10,528,684  15
75 Diltiazem Hydrochloride 10,505,373 0
76 Hydroxyzine 10,431,206  23
77 Amitriptyline 10,282,767  10
78 Doxycycline 10,191,744  35
79 Ethinyl Estradiol; Norgestimate 10,166,878  17
80 Lisdexamfetamine Dimesylate 10,011,145  11
81 Sitagliptin Phosphate 9,813,527  14
82 Latanoprost 8,975,788  1
83 Cephalexin 8,938,064  19
84 Tizanidine 8,901,700  5
85 Finasteride 8,876,331  1
86 Lovastatin 8,769,143  2
87 Topiramate 8,648,513  10
88 Insulin Lispro 8,512,587  36
89 Sulfamethoxazole; Trimethoprim 8,448,278  32
90 Buspirone Hydrochloride 8,149,119  10
91 Oseltamivir Phosphate 8,139,836  68
92 Amoxicillin; Clavulanate Potassium 7,974,978  24
93 Valsartan 7,694,037  8
94 Levetiracetam 7,666,166  16
95 Hydralazine Hydrochloride 7,545,026  10
96 Mirtazapine 7,504,257  23
97 Rivaroxaban 7,429,839  12
98 Aripiprazole 7,406,248  14
99 Oxybutynin 7,339,185  1
100 Esomeprazole 7,227,318  12
101 Alendronate Sodium 7,119,333  11
102 Folic Acid 7,099,659  6
103 Triamcinolone 6,848,479 0
104 Tiotropium 6,762,985  22
105 Thyroid 6,741,066  25
106 Ciprofloxacin 6,736,471  1
107 Isosorbide Mononitrate 6,698,824  4
108 Sumatriptan 6,674,685  11
109 Insulin Detemir 6,593,849  5
110 Benzonatate 6,493,593  38
111 Famotidine 6,470,718  4
112 Diazepam 6,448,085  23
113 Ropinirole Hydrochloride 6,224,574  5
114 Hydrochlorothiazide; Triamterene 6,007,404  13
115 Benazepril Hydrochloride 5,920,052  11
116 Metronidazole 5,852,534  58
117 Methocarbamol 5,849,167  61
118 Nifedipine 5,649,892  2
119 Baclofen 5,642,530  21
120 Methotrexate 5,518,246  3
121 Ezetimibe 5,476,606  30
122 Celecoxib 5,445,346  16
123 Guanfacine 5,429,776  8
124 Donepezil Hydrochloride 5,412,435  3
125 Hydroxychloroquine 5,406,190  3
126 Clindamycin 5,375,352  11
127 Divalproex Sodium 5,275,298  1
128 Morphine 5,225,088  27
129 Ethinyl Estradiol; Levonorgestrel 5,222,138  7
130 Prednisolone 5,202,600  1
131 Enalapril Maleate 5,182,854  9
132 Pioglitazone 5,178,776  7
133 Cyanocobalamin 5,107,466  37
134 Norethindrone 5,100,249  7
135 Meclizine Hydrochloride 4,960,255  26
136 Valacyclovir 4,931,639  16
137 Albuterol Sulfate; Ipratropium Bromide 4,789,978  35
138 Docusate 4,788,381  15
139 Liraglutide 4,771,233  24
140 Verapamil Hydrochloride 4,492,362  5
141 Cefdinir 4,361,025  57
142 Nortriptyline Hydrochloride 4,346,899  41
143 Timolol 4,312,018  3
144 Dulaglutide 4,223,559  88
145 Promethazine Hydrochloride 4,171,551  2
146 Acyclovir 4,170,803  20
147 Fluconazole 4,115,042  35
148 Methylprednisolone 4,045,962  9
149 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205  10
150 Ramipril 3,989,667  16
151 Dexmethylphenidate Hydrochloride 3,961,348  38
152 Brimonidine Tartrate 3,929,927  15
153 Oxcarbazepine 3,915,508  54
154 Risperidone 3,909,621  2
155 Levofloxacin 3,892,600  10
156 Chlorthalidone 3,883,003  17
157 Atomoxetine Hydrochloride 3,848,913  42
158 Polyethylene Glycol 3350 3,829,568  4
159 Calcium; Cholecalciferol 3,824,225  77
160 Mupirocin 3,798,015  26
161 Ethinyl Estradiol; Etonogestrel 3,772,808  16
162 Drospirenone; Ethinyl Estradiol 3,759,495  64
163 Phentermine 3,683,239  47
164 Carbidopa; Levodopa 3,638,766  20
165 Omega-3-acid Ethyl Esters 3,635,260  7
166 Desogestrel; Ethinyl Estradiol 3,633,965  2
167 Guaifenesin 3,578,369  67
168 Rizatriptan Benzoate 3,490,815  36
169 Irbesartan 3,490,431  51
170 Doxazosin Mesylate 3,417,127  20
171 Linagliptin 3,390,520  29
172 Adalimumab 3,369,130  3
173 Nitrofurantoin 3,364,026  12
174 Budesonide 3,312,207  16
175 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178  15
176 Hydrochlorothiazide; Valsartan 3,261,560  43
177 Digoxin 3,251,214  9
178 Acetaminophen; Butalbital 3,242,635  9
179 Insulin Degludec 3,226,387  86
180 Ketoconazole 3,222,574  39
181 Temazepam 3,173,561  39
182 Amiodarone Hydrochloride 3,171,077  14
183 Hydrocortisone 3,139,816  29
184 Memantine Hydrochloride 3,129,750  35
185 Canagliflozin 3,108,372  7
186 Ketorolac Tromethamine 3,085,293  85
187 Liothyronine Sodium 3,081,151  65
188 Lithium 3,077,611  8
189 Dicyclomine Hydrochloride 3,076,088  8
190 Pramipexole Dihydrochloride 2,984,633  11
191 Nebivolol Hydrochloride 2,955,158  47
192 Terazosin 2,954,414  2
193 Colchicine 2,925,875  8
194 Magnesium 2,905,858  23
195 Sucralfate 2,896,601  23
196 Medroxyprogesterone Acetate 2,866,848  26
197 Glyburide 2,841,093  23
198 Carbamazepine 2,840,744  22
199 Gemfibrozil 2,837,065  61
200 Nystatin 2,806,963  30
201 Sildenafil 2,782,913  16
202 Prazosin Hydrochloride 2,729,531  25
203 Beclomethasone 2,724,773  50
204 Linaclotide 2,697,352  53
205 Desvenlafaxine 2,690,813  30
206 Insulin Human; Insulin Isophane Human 2,689,053 0
207 Clobetasol Propionate 2,652,282  2
208 Empagliflozin 2,649,791  20
209 Lansoprazole 2,618,597  21
210 Erythromycin 2,552,822  5
211 Guaifenesin; Codeine Phosphate; Pseudoephedrine Hydrochloride 2,528,825 0
212 Bumetanide 2,468,002  65
213 Dexlansoprazole 2,464,913  11
214 Mometasone 2,464,820  17
215 Estrogens, Conjugated 2,436,386  9
216 Hydromorphone Hydrochloride 2,378,610  11
217 Letrozole 2,377,550  88
218 Olanzapine 2,354,778  21
219 Levocetirizine Dihydrochloride 2,348,311  44
220 Cyclosporine 2,323,787  28
221 Dapagliflozin 2,304,572  38
222 Labetalol 2,297,672  11
223 Anastrozole 2,292,337  35
224 Mesalamine 2,284,281  22
225 Mirabegron 2,266,031  34
226 Lidocaine 2,225,382  18
227 Mycophenolate Mofetil 2,176,530  27
228 Ofloxacin 2,164,888  50
229 Indomethacin 2,160,197  62
230 Penicillin V 2,157,185  12
231 Metoclopramide Hydrochloride 2,087,258  22
232 Olmesartan Medoxomil 2,068,391  9
233 Azelastine Hydrochloride 2,047,699  64
234 Emtricitabine 2,045,343  10
235 Ipratropium 2,023,254  19
236 Tamoxifen Citrate 2,009,016  15
237 Lurasidone Hydrochloride 2,006,353  37
238 Buprenorphine 1,984,590 0
239 Calcitriol 1,977,245  17
240 Ranolazine 1,971,575  33
241 Dorzolamide Hydrochloride; Timolol Maleate 1,950,346  8
242 Formoterol Fumarate; Mometasone Furoate 1,944,944  1
243 Betamethasone 1,920,813  78
244 Tadalafil 1,893,022  38
245 Dextroamphetamine Sulfate 1,888,101 0
246 Methimazole 1,850,309  2
247 Umeclidinium Bromide; Vilanterol Trifenatate 1,821,792  66
248 Umeclidinium Bromide 1,814,589  77
249 Diphenhydramine Hydrochloride 1,805,034  8
250 Ticagrelor 1,793,510  76
251 Fexofenadine Hydrochloride 1,787,628  6
252 Sotalol Hydrochloride 1,770,181  15
253 Sodium Fluoride 1,758,373  6
254 Insulin Isophane 1,747,834 0
255 Solifenacin Succinate 1,736,710  28
256 Flecainide Acetate 1,731,229  33
257 Benztropine Mesylate 1,717,959  31
258 Eszopiclone 1,715,221  44
259 Polymyxin B Sulfate; Trimethoprim Sulfate 1,703,423  49
260 Phenytoin 1,643,497  39
261 Bromfenac Sodium; Prednisolone Acetate; Gatifloxacin 1,638,402 0
262 Sodium 1,628,346  37
263 Torsemide 1,617,596  1
264 Tolterodine Tartrate 1,600,521  35
265 Bimatoprost 1,578,329  34
266 Etanercept 1,570,656  43
267 Travoprost 1,561,303  55
268 Minocycline Hydrochloride 1,556,983  31
269 Bisoprolol Fumarate; Hydrochlorothiazide 1,556,622  58
270 Nabumetone 1,554,892  45
271 Isotretinoin 1,531,101  73
272 Doxepin Hydrochloride 1,519,876  32
273 Calcium 1,462,841  11
274 Primidone 1,437,305  36
275 Dexamethasone 1,417,570  47
276 Bisoprolol Fumarate 1,396,798  8
277 Exenatide 1,365,998  17
278 Chlorhexidine 1,361,682  8
279 Ethinyl Estradiol; Norgestrel 1,346,880  5
280 Dutasteride 1,337,420  4
281 Modafinil 1,325,982  47
282 Olopatadine 1,311,453  12
283 Fentanyl 1,296,490  33
284 Telmisartan 1,295,783  35
285 Polyethylene Glycol 3350;;;; 1,279,925  96
286 Tretinoin 1,264,213  7
287 Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate 1,261,712  82
288 Pseudoephedrine 1,255,713  71
289 Insulin Human 1,252,990  216
290 Sacubitril; Valsartan 1,249,668 0
291 Brompheniramine Maleate; Dextromethorphan Hydrobromide; Pseudoephedrine Hydrochloride 1,228,852  29
292 Niacin 1,213,923  2
293 Betamethasone Dipropionate; Clotrimazole 1,197,967  7
294 Hydrochlorothiazide; Olmesartan Medoxomil 1,184,229  2
295 Amantadine 1,183,501 0
296 Naltrexone 1,177,679 0
297 Alfuzosin Hydrochloride 1,159,368  31
298 Ciclopirox 1,158,717  76
299 Dorzolamide Hydrochloride 1,158,075  18
300 Levalbuterol 1,155,525  36

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2018 calendar year), MEPS releasing the data from patients (August 2020), and the ClinCalc DrugStats release (a few months later, classified as the 2021 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.0. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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