The Top 300 of 2019

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2019

Rank Drug Name Total Prescriptions (2019) Total Patients (2019) Annual Change
1 Atorvastatin 112,104,359 24,493,971 0
2 Levothyroxine 102,595,103 19,698,087 0
3 Lisinopril 91,862,708 19,990,170 0
4 Metformin 85,739,443 17,430,765 0
5 Metoprolol 74,578,817 15,177,787  1
6 Amlodipine 73,542,114 16,419,181  1
7 Albuterol 60,679,987 19,085,418 0
8 Omeprazole 52,546,641 12,869,290 0
9 Losartan 51,773,869 11,760,646 0
10 Gabapentin 47,149,505 9,818,634  1
11 Hydrochlorothiazide 38,609,803 9,358,879  2
12 Sertraline 37,157,933 7,723,122  2
13 Simvastatin 36,812,966 8,543,612  3
14 Montelukast 32,154,358 7,429,725  1
15 Acetaminophen; Hydrocodone 30,355,778 10,409,764  3
16 Pantoprazole 28,880,217 6,777,996  2
17 Furosemide 28,352,226 6,640,042 0
18 Fluticasone 27,893,102 9,564,147  1
19 Escitalopram 27,510,958 6,016,820  2
20 Fluoxetine 27,110,302 5,143,421  2
21 Rosuvastatin 27,041,319 6,129,254  7
22 Bupropion 25,722,873 5,520,278  5
23 Amoxicillin 25,702,634 20,368,921  7
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 24,600,698 3,576,687 0
25 Trazodone 23,934,213 5,066,449  5
26 Duloxetine 23,821,965 4,296,613  9
27 Prednisone 22,889,929 10,999,246  7
28 Tamsulosin 21,934,065 5,309,654  3
29 Ibuprofen 21,746,702 10,951,995  3
30 Citalopram 21,546,700 4,050,776  4
31 Meloxicam 21,459,849 6,484,210  2
32 Pravastatin 20,683,277 4,875,694  3
33 Carvedilol 20,602,256 4,553,133  1
34 Potassium 20,001,670 4,589,222  5
35 Tramadol 19,838,715 5,496,843  10
36 Clopidogrel 19,447,746 4,256,662  1
37 Insulin Glargine 19,211,653 3,708,654  14
38 Aspirin 18,143,138 4,646,616 0
39 Atenolol 18,091,488 3,788,125  2
40 Venlafaxine 17,713,653 3,035,802  9
41 Alprazolam 17,533,262 3,925,013  5
42 Ethinyl Estradiol; Norethindrone 16,505,642 3,462,531  15
43 Allopurinol 15,900,788 3,637,367  5
44 Hydrochlorothiazide; Lisinopril 15,709,833 3,277,894  6
45 Cyclobenzaprine 15,597,385 5,379,870  3
46 Clonazepam 15,578,495 2,347,398 0
47 Zolpidem 15,419,648 3,013,103  13
48 Azithromycin 15,300,433 11,577,286  3
49 Oxycodone 14,669,103 4,730,687  2
50 Warfarin 14,632,370 2,789,155  1
51 Methylphenidate 14,233,405 2,173,470  7
52 Apixaban 14,042,889 3,037,557  13
53 Ranitidine 13,586,751 3,781,812  13
54 Glipizide 13,424,610 2,939,354  11
55 Ergocalciferol 13,273,652 4,124,239  6
56 Quetiapine 13,114,560 1,966,742  3
57 Budesonide; Formoterol 12,473,902 2,754,790  5
58 Estradiol 12,393,425 2,860,475  2
59 Acetaminophen; Oxycodone 11,962,650 3,850,554  6
60 Ondansetron 11,856,066 5,284,836  4
61 Naproxen 11,762,233 4,575,857  6
62 Glimepiride 11,504,531 2,277,208  8
63 Spironolactone 11,432,027 2,985,578 0
64 Clonidine 11,418,367 2,178,697  9
65 Insulin Lispro 11,389,229 2,433,328  28
66 Loratadine 11,374,226 3,311,472  9
67 Cetirizine 11,110,560 3,439,020  12
68 Topiramate 10,927,224 2,035,700  23
69 Lorazepam 10,875,212 2,837,061  11
70 Ethinyl Estradiol; Norgestimate 10,860,083 2,372,165  10
71 Lamotrigine 10,690,317 1,818,670  3
72 Diltiazem 10,604,813 2,159,158  4
73 Hydrochlorothiazide; Losartan 10,268,139 2,318,012  19
74 Diclofenac 10,115,975 4,025,423  7
75 Hydroxyzine 9,898,263 2,977,526  2
76 Buspirone 9,881,603 2,172,778  19
77 Latanoprost 9,800,569 2,454,924  7
78 Paroxetine 9,783,755 2,043,795  6
79 Lisdexamfetamine 9,775,262 1,485,285  3
80 Fluticasone; Salmeterol 9,762,036 2,315,744  14
81 Pregabalin 9,625,189 1,731,352  12
82 Propranolol 9,277,061 2,421,089  30
83 Cephalexin 9,246,463 6,267,878  2
84 Cholecalciferol 9,068,152 2,424,272  15
85 Insulin Aspart 9,067,406 1,854,475  11
86 Finasteride 8,986,897 2,314,978  2
87 Fenofibrate 8,970,219 2,057,889  16
88 Sitagliptin 8,866,811 1,649,524  5
89 Folic Acid 8,860,645 2,096,607  18
90 Doxycycline 8,809,374 5,335,777  11
91 Rivaroxaban 8,799,404 1,988,539  11
92 Tizanidine 8,729,694 2,243,428  5
93 Amoxicillin; Clavulanate 8,372,244 6,468,086  1
94 Amitriptyline 8,178,156 1,861,683  16
95 Lovastatin 8,091,735 1,897,500  5
96 Alendronate 7,811,899 2,010,715  10
97 Levetiracetam 7,560,850 1,443,028  1
98 Sumatriptan 7,050,329 1,839,891  14
99 Hydralazine 6,655,156 1,694,706  1
100 Sulfamethoxazole; Trimethoprim 6,630,866 4,339,439  6
101 Aripiprazole 6,625,791 1,370,773  2
102 Celecoxib 6,595,236 1,905,201  29
103 Ferrous Sulfate 6,417,568 2,135,927  14
104 Famotidine 6,355,768 2,287,703  11
105 Benzonatate 6,354,434 3,974,773  9
106 Mirtazapine 6,332,488 1,231,211  5
107 Triamcinolone 6,320,751 4,026,933  1
108 Ezetimibe 6,221,674 1,427,468  21
109 Fluticasone; Vilanterol 6,098,161 1,248,072  11
110 Valacyclovir 5,987,835 2,824,569  34
111 Methotrexate 5,937,198 1,082,328  17
112 Oxybutynin 5,901,953 1,476,858  8
113 Ciprofloxacin 5,878,441 4,027,141  6
114 Valproate 5,824,937 910,407  21
115 Triamterene; Hydrochlorothiazide 5,792,730 1,313,745  3
116 Thyroid 5,729,895 1,015,144  7
117 Diazepam 5,711,206 1,600,062  1
118 Nifedipine 5,638,841 1,235,265  6
119 Clindamycin 5,588,597 3,047,976  17
120 Donepezil 5,538,291 1,432,688  14
121 Insulin Detemir 5,534,526 1,114,545  8
122 Hydroxychloroquine 5,440,844 1,220,122  11
123 Isosorbide 5,420,352 1,196,717  12
124 Ethinyl Estradiol; Levonorgestrel 5,372,880 1,462,023  14
125 Baclofen 5,366,102 1,428,051 0
126 Testosterone 5,339,785 1,225,167  1
127 Esomeprazole 5,305,918 1,296,630  22
128 Desogestrel; Ethinyl Estradiol 5,264,389 1,110,114  44
129 Oseltamivir 5,214,926 4,417,445  33
130 Benazepril 5,180,063 1,334,128  9
131 Dexmethylphenidate 5,179,401 714,477  29
132 Tiotropium 5,177,802 1,174,965  22
133 Fluconazole 5,149,547 3,048,599  3
134 Dulaglutide 5,095,034 1,115,444  20
135 Chlorthalidone 4,986,853 1,195,004  29
136 Methocarbamol 4,888,933 1,764,142  13
137 Enalapril 4,669,056 958,638  3
138 Metronidazole 4,664,907 2,898,583  16
139 Prednisolone 4,638,327 2,547,930 0
140 Guanfacine 4,608,026 690,784  8
141 Verapamil 4,593,421 927,301  8
142 Liraglutide 4,524,862 973,972  5
143 Norethindrone 4,514,574 1,096,191  1
144 Ropinirole 4,487,533 997,625  27
145 Acetaminophen 4,483,857 2,536,254  59
146 Empagliflozin 4,459,539 914,424  70
147 Hydrocortisone 4,382,981 2,143,789  1
148 Drospirenone; Ethinyl Estradiol 4,348,309 943,259  20
149 Risperidone 4,285,907 663,688  12
150 Meclizine 4,258,968 1,439,405  7
151 Albuterol; Ipratropium 4,231,364 1,046,066  6
152 Adalimumab 4,208,358 553,816  27
153 Nortriptyline 4,190,832 788,683  1
154 Valsartan 4,158,666 1,072,224  57
155 Cyanocobalamin 4,061,263 1,191,271  29
156 Etonogestrel; Ethinyl Estradiol 4,050,295 834,116  11
157 Acyclovir 3,950,520 1,308,357  1
158 Phentermine 3,842,226 1,017,109  11
159 Cefdinir 3,839,266 3,008,107  8
160 Timolol 3,833,125 1,052,388  7
161 Methylprednisolone 3,812,202 2,834,344  4
162 Oxcarbazepine 3,796,002 632,006 0
163 Morphine 3,756,696 636,123  26
164 Olmesartan 3,742,011 1,000,776  78
165 Dicyclomine 3,730,730 1,156,286  32
166 Pramipexole 3,685,677 735,018  32
167 Azelastine 3,669,768 1,247,976  56
168 Insulin Degludec 3,632,525 773,441  18
169 Memantine 3,631,969 831,395  22
170 Prazosin 3,624,710 616,417  39
171 Ketoconazole 3,573,982 1,796,305  16
172 Rizatriptan 3,514,594 857,676  2
173 Acetaminophen; Codeine 3,508,582 1,971,731  23
174 Promethazine 3,392,438 1,547,216  19
175 Metformin; Sitagliptin 3,363,543 668,951  17
176 Anastrozole 3,338,664 811,943  56
177 Desvenlafaxine 3,283,561 590,830  36
178 Ramipril 3,271,102 853,882  19
179 Pioglitazone 3,241,839 858,233  38
180 Clobetasol 3,226,423 1,688,723  35
181 Irbesartan 3,220,533 896,653  6
182 Levofloxacin 3,202,649 1,995,684  19
183 Amiodarone 3,185,474 714,249  7
184 Nitroglycerin 3,165,204 1,274,921  4
185 Olanzapine 3,165,180 528,975  42
186 Sucralfate 3,161,187 892,843  16
187 Docusate 3,136,752 1,377,989  41
188 Progesterone 3,070,724 722,137  15
189 Mirabegron 3,065,676 742,152  46
190 Mupirocin 3,064,118 2,172,326  24
191 Nebivolol 3,061,887 667,364  8
192 Nitrofurantoin 2,957,359 1,608,563  12
193 Levocetirizine 2,913,554 805,527  35
194 Methimazole 2,901,300 544,953  49
195 Cyclosporine 2,889,776 904,132  34
196 Sildenafil 2,877,293 973,315  12
197 Carbamazepine 2,864,887 478,023  8
198 Labetalol 2,825,281 653,627  33
199 Calcium; Cholecalciferol 2,777,842 621,965  29
200 Lansoprazole 2,772,218 632,804  17
201 Budesonide 2,749,945 886,015  20
202 Colchicine 2,741,108 911,816  1
203 Terazosin 2,736,027 607,817  3
204 Umeclidinium; Vilanterol 2,697,882 467,017  56
205 Lithium 2,643,601 425,396  9
206 Digoxin 2,607,773 580,966  22
207 Dorzolamide; Timolol 2,590,909 657,541  44
208 Melatonin 2,586,637 694,786  64
209 Insulin Human; Insulin Isophane Human 2,528,165 538,930  5
210 Doxazosin 2,515,836 648,593  34
211 Ranolazine 2,501,299 405,880  39
212 Gemfibrozil 2,367,670 545,798  6
213 Amlodipine; Benazepril 2,332,425 570,960  31
214 Temazepam 2,324,388 628,800  25
215 Flecainide 2,318,516 461,028  51
216 Ticagrelor 2,299,436 402,097  46
217 Brimonidine 2,290,788 675,178  5
218 Dexlansoprazole 2,290,526 482,099  3
219 Lidocaine 2,273,902 1,085,302  17
220 Lurasidone 2,258,860 337,130  27
221 Benztropine 2,238,056 352,987  47
222 Nystatin 2,185,148 1,101,946  15
223 Eszopiclone 2,166,392 518,564  46
224 Sacubitril; Valsartan 2,165,813 435,484  76
225 Calcium Citrate 2,130,298 590,726  63
226 Sodium 2,117,733 792,775  8
227 Torsemide 2,117,192 476,144  46
228 Butalbital; Acetaminophen; Caffeine 2,116,128 694,354  43
229 Mesalamine 2,109,084 538,910  4
230 Liothyronine 2,083,234 439,905  35
231 Buprenorphine 2,072,033 273,376  17
232 Ofloxacin 2,051,823 1,422,882  6
233 Erythromycin 2,041,420 1,373,882  14
234 Doxepin 2,033,456 550,406  43
235 Semaglutide 2,021,060 610,492  162
236 Hydromorphone 2,013,469 541,502  12
237 Penicillin V 2,005,184 1,455,073  3
238 Valsartan; Hydrochlorothiazide 1,993,866 465,719  55
239 Beclomethasone 1,993,298 742,497  29
240 Brimonidine; Timolol 1,990,438 470,874  62
241 Bumetanide 1,990,418 420,604  21
242 Letrozole 1,981,574 368,191  17
243 Linagliptin 1,941,245 380,780  65
244 Tretinoin 1,937,920 948,930  53
245 Minocycline 1,925,676 609,265  35
246 Ipratropium 1,898,297 686,638  1
247 Polyethylene Glycol 3350 1,874,075 799,097  21
248 Umeclidinium 1,869,725 317,557  13
249 Bisoprolol 1,863,725 307,090  37
250 Calcitriol 1,847,312 430,582  1
251 Varenicline 1,836,461 663,856  72
252 Epinephrine 1,756,817 1,369,809  8
253 Estrogens, Conjugated 1,748,939 398,483 0
254 Glyburide 1,743,041 460,726  50
255 Guaifenesin 1,716,663 1,136,061  63
256 Magnesium Acetate 1,712,179 533,710  15
257 Ethinyl Estradiol; Norgestrel 1,704,321 300,727  33
258 Sotalol 1,698,717 353,633  5
259 Bimatoprost 1,697,723 410,702  17
260 Insulin Isophane 1,674,609 372,003  4
261 Medroxyprogesterone 1,661,971 644,481  58
262 Tamoxifen 1,656,753 405,119  16
263 Mometasone 1,638,401 463,974  41
264 Sulfasalazine 1,632,254 375,613  79
265 Dorzolamide 1,615,872 463,403  48
266 Ketorolac 1,602,923 1,110,598  72
267 Indomethacin 1,574,456 770,570  28
268 Atomoxetine 1,563,862 375,184  103
269 Olopatadine 1,561,992 719,835  24
270 Telmisartan 1,553,265 383,898  25
271 Phenytoin 1,536,389 298,537 0
272 Buprenorphine; Naloxone 1,514,317 180,019  80
273 Raloxifene 1,510,334 340,374  74
274 Tobramycin; Dexamethasone 1,486,152 797,964  97
275 Naltrexone 1,465,584 349,282  28
276 Polymyxin B; Trimethoprim 1,450,395 1,019,455  6
277 Terbinafine 1,441,827 677,406  54
278 Fentanyl 1,440,011 237,302  16
279 Diphenhydramine 1,433,911 506,643  20
280 Bisoprolol; Hydrochlorothiazide 1,433,172 294,136  1
281 Pancrelipase Lipase; Pancrelipase Protease; Pancrelipase Amylase 1,433,033 355,077  20
282 Zonisamide 1,432,118 222,847 0
283 Fexofenadine 1,428,320 468,086  25
284 Erenumab 1,416,499 237,083 0
285 Linaclotide 1,399,268 335,650  74
286 Brompheniramine; Dextromethorphan; Pseudoephedrine 1,396,531 845,363  18
287 Omega-3-acid Ethyl Esters 1,391,748 421,905  110
288 Dimethyl 1,386,389 227,231 0
289 Tadalafil 1,379,014 411,977  34
290 Canagliflozin 1,373,539 304,908  97
291 Emtricitabine; Tenofovir Disoproxil 1,345,532 189,668  36
292 Tolterodine 1,340,859 387,878  17
293 Etanercept 1,320,548 235,493  15
294 Quinapril 1,318,428 300,038  41
295 Senna; Docusate 1,313,539 610,326  78
296 Betamethasone 1,311,106 914,208  42
297 Solifenacin 1,307,159 317,209  32
298 Insulin, Regular, Human 1,298,682 213,288  1
299 Chlorhexidine 1,295,645 793,562  10
300 Fluocinonide 1,290,749 595,456  22

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2019 calendar year), MEPS releasing the data from patients (August 2021), and the ClinCalc DrugStats release (a few months later, classified as the 2019 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

Search

Related Links

Follow Us!

New and Popular

Loading...

Open Menu

Cite This Page

Show AMA citation

Gorillas can't learn drug therapy ... but you can. The Top 250 Drugs by ClinCalc Academy
 
©2021 - ClinCalc LLC. All rights reserved.
Disclaimer - Privacy Policy - Contact Us
Updated Sep 12, 2021
Back to Top
Top