The Top 300 of 2020

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2020

Rank Drug Name Total Prescriptions (2017) Annual Change
1 Lisinopril 104,779,318  1
2 Atorvastatin 104,774,006  1
3 Levothyroxine 101,932,430  2
4 Metformin Hydrochloride 78,602,870 0
5 Amlodipine 72,508,878 0
6 Metoprolol 68,076,156 0
7 Omeprazole 58,837,874 0
8 Simvastatin 56,708,617 0
9 Losartan Potassium 51,989,444 0
10 Albuterol 50,286,686 0
11 Gabapentin 46,043,168 0
12 Hydrochlorothiazide 42,037,081 0
13 Acetaminophen; Hydrocodone Bitartrate 40,123,144 0
14 Sertraline Hydrochloride 38,296,630 0
15 Fluticasone 32,049,111  1
16 Montelukast 31,953,728  7
17 Furosemide 30,583,265  2
18 Amoxicillin 27,913,807 0
19 Pantoprazole Sodium 27,081,977  6
20 Escitalopram Oxalate 25,960,468  6
21 Alprazolam 25,516,329  2
22 Prednisone 25,028,445  9
23 Bupropion 24,903,971  5
24 Pravastatin Sodium 24,812,698  3
25 Acetaminophen 24,742,095  8
26 Citalopram 24,434,272  5
27 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 24,155,783  18
28 Ibuprofen 24,070,989  7
29 Carvedilol 22,974,069  1
30 Trazodone Hydrochloride 22,311,417  6
31 Fluoxetine Hydrochloride 21,913,275  2
32 Tramadol Hydrochloride 21,096,312  7
33 Insulin Glargine 20,715,011  11
34 Clonazepam 20,708,621  8
35 Tamsulosin Hydrochloride 20,313,916  3
36 Atenolol 20,208,476  16
37 Potassium 19,821,825  4
38 Meloxicam 19,793,506  2
39 Rosuvastatin 19,628,896  2
40 Clopidogrel Bisulfate 19,389,806  6
41 Propranolol Hydrochloride 17,749,819  2
42 Aspirin 17,299,288  4
43 Cyclobenzaprine 17,148,429  3
44 Hydrochlorothiazide; Lisinopril 16,687,918  9
45 Glipizide 16,619,798  1
46 Duloxetine 16,512,763  2
47 Methylphenidate 16,450,268 0
48 Ranitidine 16,369,541  2
49 Venlafaxine 16,080,521  2
50 Zolpidem Tartrate 15,899,894  10
51 Warfarin 15,190,524  10
52 Oxycodone 15,111,150  2
53 Ethinyl Estradiol; Norethindrone 14,961,803  2
54 Allopurinol 14,835,618  2
55 Ergocalciferol 14,578,147  1
56 Insulin Aspart 14,259,045  31
57 Azithromycin 12,690,152  8
58 Metronidazole 12,657,176  13
59 Loratadine 12,402,146  6
60 Lorazepam 12,359,439  3
61 Estradiol 12,358,564  2
62 Ethinyl Estradiol; Norgestimate 12,316,410  4
63 Lamotrigine 12,053,690  7
64 Glimepiride 12,044,087  3
65 Fluticasone Propionate; Salmeterol Xinafoate 12,025,244  3
66 Cetirizine 11,818,750  8
67 Hydrochlorothiazide; Losartan Potassium 11,752,545  13
68 Paroxetine 11,670,683  4
69 Spironolactone 11,641,507  3
70 Fenofibrate 11,535,943  3
71 Naproxen 11,334,305  3
72 Pregabalin 11,152,692  11
73 Insulin Human 10,617,873  11
74 Budesonide; Formoterol 10,587,157  3
75 Diltiazem Hydrochloride 10,486,476  12
76 Quetiapine Fumarate 10,402,693  10
77 Topiramate 10,388,097  8
78 Bacitracin; Neomycin; Polymyxin B 10,306,528  3
79 Clonidine 10,239,431  3
80 Buspirone Hydrochloride 10,195,216  10
81 Latanoprost 9,937,126  2
82 Tiotropium 9,507,922  13
83 Ondansetron 9,484,904  8
84 Lovastatin 9,453,814  12
85 Valsartan 9,231,279  7
86 Finasteride 9,132,613  11
87 Amitriptyline 9,105,080  1
88 Esomeprazole 9,036,551  19
89 Tizanidine 9,005,251  29
90 Alendronate Sodium 8,959,166  17
91 Lisdexamfetamine Dimesylate 8,884,101  8
92 Ferrous Sulfate 8,698,003  1
93 Apixaban 8,662,640  30
94 Diclofenac 8,557,078  16
95 Sitagliptin Phosphate 8,485,403  13
96 Folic Acid 8,284,498 0
97 Sumatriptan 8,126,158  18
98 Drospirenone; Ethinyl Estradiol 8,038,487  11
99 Hydroxyzine 7,944,928  2
100 Oxybutynin 7,935,806  8
101 Hydrochlorothiazide; Triamterene 7,631,431  41
102 Cephalexin 7,240,287  5
103 Triamcinolone 7,190,528  19
104 Benazepril Hydrochloride 7,163,351 0
105 Hydralazine Hydrochloride 7,117,425  33
106 Celecoxib 7,036,320  14
107 Ciprofloxacin 6,976,541  5
108 Ropinirole Hydrochloride 6,915,600  3
109 Rivaroxaban 6,836,386  4
110 Levetiracetam 6,832,916  21
111 Isosorbide Mononitrate 6,704,638  10
112 Aripiprazole 6,695,764  19
113 Doxycycline 6,681,548  3
114 Insulin Detemir 6,620,839  7
115 Famotidine 6,412,032  10
116 Amoxicillin; Clavulanate Potassium 6,398,915  2
117 Methotrexate 6,291,779  35
118 Hydrocodone Bitartrate 6,283,981  5
119 Mirtazapine 6,258,585  9
120 Nifedipine 6,213,120  34
121 Sulfamethoxazole; Trimethoprim 6,212,552  15
122 Enalapril Maleate 6,121,954  28
123 Docusate 6,107,372  4
124 Insulin Lispro 6,080,310  24
125 Pioglitazone 5,967,857  9
126 Divalproex Sodium 5,945,499  3
127 Donepezil Hydrochloride 5,677,780  29
128 Hydroxychloroquine Sulfate 5,666,999  7
129 Prednisolone 5,648,795  7
130 Thyroid 5,539,696  11
131 Guanfacine 5,451,594  25
132 Testosterone 5,441,196  14
133 Hydrochlorothiazide; Valsartan 5,341,254  1
134 Ramipril 5,318,556  19
135 Diazepam 5,184,805  23
136 Ethinyl Estradiol; Levonorgestrel 4,987,668  19
137 Clindamycin 4,934,442  14
138 Gemfibrozil 4,770,181  6
139 Metformin Hydrochloride; Sitagliptin Phosphate 4,735,729  52
140 Baclofen 4,587,435  16
141 Norethindrone 4,576,580  124
142 Temazepam 4,562,712  43
143 Nitroglycerin 4,538,115  37
144 Nebivolol Hydrochloride 4,473,865  18
145 Verapamil Hydrochloride 4,373,950  15
146 Timolol 4,369,477  4
147 Promethazine Hydrochloride 4,352,207  13
148 Benzonatate 4,335,738  45
149 Memantine Hydrochloride 4,327,217  2
150 Doxazosin Mesylate 4,313,778  7
151 Ezetimibe 4,260,208  7
152 Valacyclovir 4,230,834  16
153 Beclomethasone 4,202,266  23
154 Hydrocortisone 4,119,058  11
155 Morphine 4,090,362  3
156 Risperidone 4,075,364  3
157 Methylprednisolone 4,074,442  9
158 Omega-3-acid Ethyl Esters 3,925,744  19
159 Oseltamivir Phosphate 3,905,474  90
160 Amlodipine Besylate; Benazepril Hydrochloride 3,896,258  20
161 Meclizine Hydrochloride 3,861,963  1
162 Polyethylene Glycol 3350 3,802,924  15
163 Liraglutide 3,802,463  25
164 Desogestrel; Ethinyl Estradiol 3,797,028  31
165 Levofloxacin 3,777,117  4
166 Acyclovir 3,769,434  29
167 Brimonidine Tartrate 3,746,507 0
168 Digoxin 3,737,121  23
169 Adalimumab 3,722,094  19
170 Cyanocobalamin 3,718,963  33
171 Magnesium 3,700,740  8
172 Albuterol Sulfate; Ipratropium Bromide 3,622,793  6
173 Chlorthalidone 3,601,956  1
174 Glyburide 3,553,318  2
175 Levocetirizine Dihydrochloride 3,528,964  12
176 Carbamazepine 3,516,203  21
177 Ethinyl Estradiol; Etonogestrel 3,504,659  37
178 Methocarbamol 3,498,249  9
179 Pramipexole Dihydrochloride 3,375,277  25
180 Lithium 3,358,268  42
181 Dicyclomine Hydrochloride 3,290,774  3
182 Fluconazole 3,238,316  9
183 Nortriptyline Hydrochloride 3,229,716  9
184 Carbidopa; Levodopa 3,219,820  9
185 Nitrofurantoin 3,199,043  1
186 Mupirocin 3,140,100  13
187 Acetaminophen; Butalbital 3,117,810  15
188 Lansoprazole 3,109,062  47
189 Dexmethylphenidate Hydrochloride 3,102,541  20
190 Budesonide 3,077,886  17
191 Mirabegron 3,044,379  72
192 Canagliflozin 3,033,478  2
193 Menthol 2,990,164 0
194 Terazosin 2,936,433  25
195 Progesterone 2,930,452  6
196 Amiodarone Hydrochloride 2,908,848  2
197 Mometasone 2,894,532  32
198 Cefdinir 2,845,144  30
199 Atomoxetine Hydrochloride 2,831,375  46
200 Linagliptin 2,823,705  4
201 Colchicine 2,804,543  50
202 Dexlansoprazole 2,696,880  12
203 Naphazoline Hydrochloride; Pheniramine Maleate 2,665,292  3
204 Rizatriptan Benzoate 2,569,059  28
205 Hydromorphone Hydrochloride 2,530,241  7
206 Estrogens, Conjugated 2,508,661  57
207 Oxcarbazepine 2,452,464  37
208 Lidocaine 2,442,572  8
209 Clobetasol Propionate 2,438,775  25
210 Phentermine 2,428,840  16
211 Labetalol 2,420,202  22
212 Travoprost 2,416,250  36
213 Guaifenesin; Codeine Phosphate; Pseudoephedrine Hydrochloride 2,416,169 0
214 Eszopiclone 2,415,978  72
215 Erythromycin 2,401,643  66
216 Ipratropium 2,397,885  34
217 Sildenafil 2,384,706  25
218 Sucralfate 2,383,592  18
219 Ketoconazole 2,358,068  14
220 Irbesartan 2,355,199  49
221 Phenytoin 2,348,515  20
222 Medroxyprogesterone Acetate 2,326,200  30
223 Olmesartan Medoxomil 2,309,370  59
224 Emtricitabine 2,272,552 0
225 Sodium 2,268,242  4
226 Benztropine Mesylate 2,253,908  15
227 Prazosin Hydrochloride 2,248,204  7
228 Empagliflozin 2,223,050  61
229 Tolterodine Tartrate 2,201,189  71
230 Nystatin 2,196,469  13
231 Bimatoprost 2,188,471  23
232 Dulaglutide 2,169,781 0
233 Dorzolamide Hydrochloride; Timolol Maleate 2,135,488  33
234 Guaifenesin 2,116,682  27
235 Desvenlafaxine 2,111,926  37
236 Calcium; Cholecalciferol 2,084,460  53
237 Minocycline Hydrochloride 2,075,752  8
238 Primidone 2,075,116  1
239 Olanzapine 2,054,103  14
240 Doxepin Hydrochloride 2,035,669  1
241 Diphenhydramine Hydrochloride 2,029,269  31
242 Penicillin V 2,014,741  7
243 Formoterol Fumarate; Mometasone Furoate 1,994,780  40
244 Methimazole 1,988,442  31
245 Fexofenadine Hydrochloride 1,983,167  59
246 Mesalamine 1,954,656  6
247 Sodium Fluoride 1,933,040  32
248 Cyclosporine 1,834,554  35
249 Telmisartan 1,820,213  3
250 Fentanyl 1,776,409  32
251 Tamoxifen Citrate 1,747,499  13
252 Liothyronine Sodium 1,740,841  5
253 Metoclopramide Hydrochloride 1,728,312  3
254 Mycophenolate Mofetil 1,727,563  74
255 Carisoprodol 1,710,143  74
256 Calcitriol 1,707,261  25
257 Linaclotide 1,681,480  52
258 Anastrozole 1,674,379  34
259 Dapagliflozin 1,639,236  65
260 Exenatide 1,635,146  33
261 Ziprasidone 1,634,321  61
262 Calcium 1,630,227  15
263 Epinephrine 1,629,651  10
264 Torsemide 1,615,074  30
265 Insulin Degludec 1,608,450 0
266 Alfuzosin Hydrochloride 1,606,982  36
267 Sotalol Hydrochloride 1,570,103  3
268 Bisoprolol Fumarate 1,558,830  14
269 Quinapril 1,536,944  61
270 Olopatadine 1,528,884  1
271 Ketorolac Tromethamine 1,528,858  25
272 Methylcellulose (4000 Mpa.S) 1,525,419  117
273 Ranolazine 1,509,098  3
274 Lurasidone Hydrochloride 1,483,689  47
275 Pancrelipase Lipase; Pancrelipase Protease; Pancrelipase Amylase 1,483,451  20
276 Dutasteride 1,477,864  2
277 Bumetanide 1,462,079  11
278 Ofloxacin 1,448,901  21
279 Rabeprazole Sodium 1,445,283  6
280 Triazolam 1,435,621  74
281 Dorzolamide Hydrochloride 1,435,032  10
282 Tadalafil 1,432,096  2
283 Solifenacin Succinate 1,423,777  113
284 Ethinyl Estradiol; Norgestrel 1,420,766  27
285 Vilazodone Hydrochloride 1,403,350  7
286 Chlorhexidine 1,387,173  56
287 Sennosides 1,377,740 0
288 Buprenorphine; Naloxone 1,350,238  101
289 Flecainide Acetate 1,342,615  16
290 Niacin 1,333,584  13
291 Indomethacin 1,304,149  25
292 Hydrochlorothiazide; Olmesartan Medoxomil 1,293,858  34
293 Tretinoin 1,291,450  4
294 Conjugated Estrogens; Medroxyprogesterone 1,273,253 0
295 Atenolol; Chlorthalidone 1,256,079  33
296 Haloperidol 1,241,881  53
297 Azelastine Hydrochloride 1,240,986  30
298 Ezetimibe; Simvastatin 1,236,842  49
299 Enoxaparin Sodium 1,226,352  4
300 Betamethasone Dipropionate; Clotrimazole 1,212,004  44

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2018 calendar year), MEPS releasing the data from patients (August 2020), and the ClinCalc DrugStats release (a few months later, classified as the 2021 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2007-2017. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 20.0. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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