The Top 300 of 2021

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Total Patients (2018) Annual Change
1 Atorvastatin 112,474,023 23,393,083  1
2 Levothyroxine 105,773,990 19,448,097  1
3 Lisinopril 97,608,879 19,941,170  2
4 Metformin Hydrochloride 83,762,981 16,865,776 0
5 Amlodipine 75,811,947 15,851,641 0
6 Metoprolol 71,581,961 14,583,646 0
7 Albuterol 60,526,457 19,211,178  3
8 Omeprazole 58,364,556 13,410,605  1
9 Losartan Potassium 50,479,750 11,160,547 0
10 Simvastatin 48,007,043 10,407,988  2
11 Gabapentin 45,586,654 9,289,873 0
12 Acetaminophen; Hydrocodone Bitartrate 42,073,176 12,268,763  1
13 Hydrochlorothiazide 40,575,075 8,869,933  1
14 Sertraline Hydrochloride 38,383,042 7,529,389 0
15 Montelukast 35,222,630 7,017,347  1
16 Fluticasone 34,253,764 10,344,619  1
17 Amoxicillin 31,371,675 21,697,269  1
18 Furosemide 29,857,945 6,330,557  1
19 Pantoprazole Sodium 28,958,134 6,531,330 0
20 Acetaminophen 27,907,360 9,379,461  5
21 Prednisone 27,057,494 11,300,598  1
22 Escitalopram Oxalate 25,978,773 5,544,406  2
23 Fluoxetine Hydrochloride 25,619,277 4,752,127  8
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775 3,705,324  3
25 Tramadol Hydrochloride 24,952,328 6,952,833  7
26 Insulin Glargine 24,911,721 4,331,519  7
27 Bupropion 24,488,843 5,046,780  4
28 Ibuprofen 24,453,501 11,636,681 0
29 Rosuvastatin 24,138,061 5,257,942  10
30 Pravastatin Sodium 24,022,031 5,420,488  6
31 Trazodone Hydrochloride 23,889,624 4,677,140  1
32 Tamsulosin Hydrochloride 23,254,004 5,943,933  3
33 Carvedilol 22,737,638 4,403,579  4
34 Meloxicam 22,610,690 6,340,662  4
35 Citalopram 22,224,263 4,267,101  9
36 Duloxetine 21,217,653 3,946,472  10
37 Alprazolam 20,843,479 4,208,452  16
38 Potassium 20,414,037 4,619,520  1
39 Clopidogrel Bisulfate 20,016,095 4,467,091  1
40 Aspirin 19,750,180 5,004,736  2
41 Ranitidine 18,739,686 4,722,448  7
42 Atenolol 18,644,884 3,975,612  6
43 Cyclobenzaprine 18,041,836 6,033,831 0
44 Glipizide 17,549,602 3,506,779  1
45 Methylphenidate 17,467,265 2,569,210  2
46 Azithromycin 17,102,628 11,910,961  11
47 Clonazepam 17,064,643 2,792,493  13
48 Oxycodone 16,967,479 4,917,269  4
49 Allopurinol 16,374,431 3,374,614  5
50 Venlafaxine 16,121,149 2,870,792  1
51 Hydrochlorothiazide; Lisinopril 15,932,877 3,147,241  7
52 Warfarin 14,772,355 2,810,629  1
53 Propranolol Hydrochloride 14,571,767 3,302,645  12
54 Hydrochlorothiazide; Losartan Potassium 13,880,262 2,797,930  13
55 Cetirizine 13,799,351 3,840,211  11
56 Estradiol 13,583,025 3,131,795  5
57 Ethinyl Estradiol; Norethindrone 13,509,602 2,908,388  4
58 Lorazepam 13,222,989 3,033,521  2
59 Quetiapine Fumarate 12,962,563 2,046,378  18
60 Zolpidem Tartrate 12,877,940 2,858,753  10
61 Ergocalciferol 12,831,209 3,774,540  6
62 Budesonide; Formoterol 12,339,319 2,712,943  13
63 Spironolactone 12,260,624 2,610,298  6
64 Ondansetron 12,240,225 5,043,859  19
65 Insulin Aspart 12,146,568 2,375,787  9
66 Apixaban 12,113,153 2,560,506  27
67 Naproxen 11,942,765 4,823,303  5
68 Lamotrigine 11,582,775 1,758,591  5
69 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537 2,447,427  4
70 Pregabalin 11,429,654 2,183,817  3
71 Glimepiride 11,405,689 2,205,422  7
72 Diclofenac 11,372,069 3,853,876  22
73 Fenofibrate 11,325,402 2,402,673  3
74 Paroxetine 11,228,908 2,062,982  6
75 Clonidine 11,141,934 1,993,687  4
76 Loratadine 10,528,684 2,837,051  17
77 Diltiazem Hydrochloride 10,505,373 2,267,803  1
78 Hydroxyzine 10,431,206 2,769,471  21
79 Amitriptyline 10,282,767 1,980,001  8
80 Doxycycline 10,191,744 5,034,775  33
81 Ethinyl Estradiol; Norgestimate 10,166,878 2,289,108  19
82 Lisdexamfetamine Dimesylate 10,011,145 1,415,486  9
83 Sitagliptin Phosphate 9,813,527 1,868,303  12
84 Latanoprost 8,975,788 2,185,662  3
85 Cephalexin 8,938,064 5,845,428  17
86 Tizanidine 8,901,700 2,152,671  3
87 Finasteride 8,876,331 2,480,924  1
88 Lovastatin 8,769,143 2,039,445  4
89 Topiramate 8,648,513 1,625,584  11
90 Insulin Lispro 8,512,587 1,490,687  34
91 Sulfamethoxazole; Trimethoprim 8,448,278 4,340,806  30
92 Buspirone Hydrochloride 8,149,119 1,774,887  12
93 Oseltamivir Phosphate 8,139,836 5,363,483  66
94 Ferrous Sulfate 8,076,467 2,232,533  2
95 Amoxicillin; Clavulanate Potassium 7,974,978 5,600,348  21
96 Valsartan 7,694,037 1,834,658  11
97 Levetiracetam 7,666,166 1,208,963  13
98 Hydralazine Hydrochloride 7,545,026 1,670,423  7
99 Mirtazapine 7,504,257 1,405,315  20
100 Rivaroxaban 7,429,839 1,607,032  9
101 Aripiprazole 7,406,248 1,303,557  11
102 Oxybutynin 7,339,185 1,758,891  2
103 Esomeprazole 7,227,318 1,678,723  15
104 Alendronate Sodium 7,119,333 1,770,748  14
105 Folic Acid 7,099,659 1,793,345  9
106 Triamcinolone 6,848,479 3,995,753  3
107 Tiotropium 6,762,985 1,267,325  25
108 Thyroid 6,741,066 1,257,094  22
109 Ciprofloxacin 6,736,471 4,388,948  2
110 Isosorbide Mononitrate 6,698,824 1,418,224  1
111 Sumatriptan 6,674,685 1,805,282  14
112 Insulin Detemir 6,593,849 1,316,376  2
113 Benzonatate 6,493,593 3,881,071  35
114 Famotidine 6,470,718 1,739,478  1
115 Diazepam 6,448,085 1,907,386  20
116 Ropinirole Hydrochloride 6,224,574 1,266,850  8
117 Hydrochlorothiazide; Triamterene 6,007,404 1,416,877  16
118 Benazepril Hydrochloride 5,920,052 1,193,413  14
119 Metronidazole 5,852,534 3,215,002  61
120 Methocarbamol 5,849,167 1,697,450  58
121 Nifedipine 5,649,892 1,331,830  1
122 Baclofen 5,642,530 1,422,574  18
123 Methotrexate 5,518,246 1,045,632  6
124 Testosterone 5,483,791 1,166,009  8
125 Ezetimibe 5,476,606 1,279,335  26
126 Celecoxib 5,445,346 1,731,739  20
127 Guanfacine 5,429,776 745,584  4
128 Donepezil Hydrochloride 5,412,435 1,200,862  1
129 Hydroxychloroquine 5,406,190 1,275,750  1
130 Clindamycin 5,375,352 3,156,696  7
131 Divalproex Sodium 5,275,298 871,064  5
132 Morphine 5,225,088 729,631  23
133 Ethinyl Estradiol; Levonorgestrel 5,222,138 1,386,810  3
134 Prednisolone 5,202,600 2,812,650  5
135 Enalapril Maleate 5,182,854 1,075,972  13
136 Pioglitazone 5,178,776 1,106,190  11
137 Cyanocobalamin 5,107,466 1,211,053  33
138 Norethindrone 5,100,249 1,315,919  3
139 Meclizine Hydrochloride 4,960,255 1,586,691  22
140 Valacyclovir 4,931,639 2,087,445  12
141 Albuterol Sulfate; Ipratropium Bromide 4,789,978 1,131,554  31
142 Docusate 4,788,381 1,806,391  19
143 Liraglutide 4,771,233 914,595  20
144 Hydrocortisone 4,530,984 2,243,072  10
145 Verapamil Hydrochloride 4,492,362 764,704 0
146 Cefdinir 4,361,025 2,668,804  52
147 Nortriptyline Hydrochloride 4,346,899 1,014,388  36
148 Timolol 4,312,018 1,056,397  2
149 Dulaglutide 4,223,559 790,653  83
150 Promethazine Hydrochloride 4,171,551 1,506,832  3
151 Acyclovir 4,170,803 1,579,679  15
152 Fluconazole 4,115,042 2,435,456  30
153 Methylprednisolone 4,045,962 3,088,134  4
154 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205 727,627  15
155 Ramipril 3,989,667 951,186  21
156 Dexmethylphenidate Hydrochloride 3,961,348 633,049  33
157 Brimonidine Tartrate 3,929,927 949,982  10
158 Oxcarbazepine 3,915,508 611,913  49
159 Risperidone 3,909,621 705,780  3
160 Levofloxacin 3,892,600 2,031,179  5
161 Chlorthalidone 3,883,003 968,260  12
162 Atomoxetine Hydrochloride 3,848,913 585,517  37
163 Polyethylene Glycol 3350 3,829,568 1,361,406  1
164 Calcium; Cholecalciferol 3,824,225 939,825  72
165 Mupirocin 3,798,015 2,382,129  21
166 Ethinyl Estradiol; Etonogestrel 3,772,808 893,254  11
167 Drospirenone; Ethinyl Estradiol 3,759,495 742,476  69
168 Phentermine 3,683,239 1,084,123  42
169 Carbidopa; Levodopa 3,638,766 715,638  15
170 Omega-3-acid Ethyl Esters 3,635,260 915,458  12
171 Desogestrel; Ethinyl Estradiol 3,633,965 769,834  7
172 Guaifenesin 3,578,369 1,945,634  62
173 Rizatriptan Benzoate 3,490,815 791,854  31
174 Irbesartan 3,490,431 917,140  46
175 Progesterone 3,436,339 803,079  20
176 Doxazosin Mesylate 3,417,127 733,303  26
177 Linagliptin 3,390,520 523,666  23
178 Adalimumab 3,369,130 474,859  9
179 Nitrofurantoin 3,364,026 1,630,343  6
180 Budesonide 3,312,207 1,007,610  10
181 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178 795,990  21
182 Hydrochlorothiazide; Valsartan 3,261,560 782,002  49
183 Digoxin 3,251,214 691,227  15
184 Acetaminophen; Butalbital 3,242,635 584,606  3
185 Insulin Degludec 3,226,387 509,604  80
186 Ketoconazole 3,222,574 1,651,757  33
187 Nitroglycerin 3,182,971 1,273,543  44
188 Temazepam 3,173,561 694,970  46
189 Amiodarone Hydrochloride 3,171,077 721,402  7
190 Memantine Hydrochloride 3,129,750 752,433  41
191 Canagliflozin 3,108,372 573,704  1
192 Ketorolac Tromethamine 3,085,293 1,273,566  79
193 Liothyronine Sodium 3,081,151 546,776  59
194 Lithium 3,077,611 452,154  14
195 Dicyclomine Hydrochloride 3,076,088 1,029,343  14
196 Pramipexole Dihydrochloride 2,984,633 577,116  17
197 Nebivolol Hydrochloride 2,955,158 594,858  53
198 Terazosin 2,954,414 650,060  4
199 Magnesium 2,940,781 775,250  28
200 Colchicine 2,925,875 753,887  1
201 Sucralfate 2,896,601 929,049  17
202 Medroxyprogesterone Acetate 2,866,848 883,490  20
203 Glyburide 2,841,093 514,404  29
204 Carbamazepine 2,840,744 403,258  28
205 Gemfibrozil 2,837,065 629,744  67
206 Nystatin 2,806,963 1,388,621  24
207 Sildenafil 2,782,913 891,124  10
208 Prazosin Hydrochloride 2,729,531 547,830  19
209 Beclomethasone 2,724,773 1,028,696  56
210 Linaclotide 2,697,352 611,873  47
211 Desvenlafaxine 2,690,813 562,137  24
212 Insulin Human; Insulin Isophane Human 2,689,053 552,060 0
213 Clobetasol Propionate 2,652,282 1,399,142  4
214 Empagliflozin 2,649,791 546,564  14
215 Lansoprazole 2,618,597 610,888  27
216 Erythromycin 2,552,822 1,118,219  1
217 Guaifenesin; Codeine Phosphate; Pseudoephedrine Hydrochloride 2,528,825 1,414,594 0
218 Bumetanide 2,468,002 382,754  59
219 Dexlansoprazole 2,464,913 500,672  17
220 Mometasone 2,464,820 909,554  23
221 Estrogens, Conjugated 2,436,386 629,120  15
222 Hydromorphone Hydrochloride 2,378,610 461,732  17
223 Letrozole 2,377,550 527,647  81
224 Olanzapine 2,354,778 506,268  15
225 Levocetirizine Dihydrochloride 2,348,311 741,821  50
226 Cyclosporine 2,323,787 857,473  22
227 Dapagliflozin 2,304,572 372,175  32
228 Labetalol 2,297,672 652,868  17
229 Anastrozole 2,292,337 520,896  29
230 Mesalamine 2,284,281 473,111  16
231 Sodium 2,269,422 793,559  6
232 Mirabegron 2,266,031 646,829  41
233 Lidocaine 2,225,382 1,069,437  25
234 Mycophenolate Mofetil 2,176,530 358,388  20
235 Ofloxacin 2,164,888 1,418,096  43
236 Indomethacin 2,160,197 726,460  55
237 Penicillin V 2,157,185 1,343,328  5
238 Metoclopramide Hydrochloride 2,087,258 617,336  15
239 Olmesartan Medoxomil 2,068,391 564,613  16
240 Azelastine Hydrochloride 2,047,699 702,012  57
241 Emtricitabine 2,045,343 383,383  17
242 Epinephrine 2,036,712 1,260,073  21
243 Ipratropium 2,023,254 754,489  27
244 Tamoxifen Citrate 2,009,016 453,646  7
245 Lurasidone Hydrochloride 2,006,353 359,127  29
246 Buprenorphine 1,984,590 234,296 0
247 Calcitriol 1,977,245 442,626  9
248 Ranolazine 1,971,575 385,010  25
249 Dorzolamide Hydrochloride; Timolol Maleate 1,950,346 443,808  16
250 Formoterol Fumarate; Mometasone Furoate 1,944,944 467,502  7
251 Betamethasone 1,920,813 998,783  69
252 Calcium 1,909,736 471,682  10
253 Tadalafil 1,893,022 403,359  29
254 Dextroamphetamine Sulfate 1,888,101 284,137 0
255 Methimazole 1,850,309 361,631  11
256 Umeclidinium Bromide; Vilanterol Trifenatate 1,821,792 459,154  56
257 Umeclidinium Bromide 1,814,589 381,278  67
258 Diphenhydramine Hydrochloride 1,805,034 592,218  17
259 Ticagrelor 1,793,510 355,226  66
260 Fexofenadine Hydrochloride 1,787,628 576,457  15
261 Sotalol Hydrochloride 1,770,181 348,821  6
262 Sodium Fluoride 1,758,373 760,191  15
263 Insulin Isophane 1,747,834 452,465 0
264 Solifenacin Succinate 1,736,710 414,990  19
265 Flecainide Acetate 1,731,229 434,232  24
266 Benztropine Mesylate 1,717,959 306,642  40
267 Eszopiclone 1,715,221 335,606  53
268 Polymyxin B Sulfate; Trimethoprim Sulfate 1,703,423 1,010,824  39
269 Phenytoin 1,643,497 240,541  48
270 Bromfenac Sodium; Prednisolone Acetate; Gatifloxacin 1,638,402 538,452 0
271 Torsemide 1,617,596 383,683  7
272 Sennosides 1,616,225 388,128  15
273 Tolterodine Tartrate 1,600,521 401,414  44
274 Bimatoprost 1,578,329 363,795  43
275 Etanercept 1,570,656 283,432  33
276 Travoprost 1,561,303 354,217  64
277 Minocycline Hydrochloride 1,556,983 524,429  40
278 Bisoprolol Fumarate; Hydrochlorothiazide 1,556,622 281,320  48
279 Nabumetone 1,554,892 380,851  35
280 Isotretinoin 1,531,101 381,253  63
281 Doxepin Hydrochloride 1,519,876 402,501  41
282 Primidone 1,437,305 255,986  44
283 Dexamethasone 1,417,570 710,165  38
284 Bisoprolol Fumarate 1,396,798 364,327  16
285 Exenatide 1,365,998 373,366  25
286 Chlorhexidine 1,361,682 926,523 0
287 Ethinyl Estradiol; Norgestrel 1,346,880 222,323  3
288 Dutasteride 1,337,420 316,322  12
289 Modafinil 1,325,982 256,470  38
290 Olopatadine 1,311,453 549,975  20
291 Fentanyl 1,296,490 223,304  41
292 Telmisartan 1,295,783 325,634  43
293 Polyethylene Glycol 3350 With Electrolytes 1,279,925 714,076  87
294 Tretinoin 1,264,213 658,461  1
295 Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate 1,261,712 752,108  73
296 Pseudoephedrine 1,255,713 645,331  62
297 Insulin Human 1,252,990 257,194  223
298 Sacubitril; Valsartan 1,249,668 249,942 0
299 Pancrelipase Lipase; Pancrelipase Protease; Pancrelipase Amylase 1,240,458 236,621  24
300 Brompheniramine Maleate; Dextromethorphan Hydrobromide; Pseudoephedrine Hydrochloride 1,228,852 649,428  19

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2019 calendar year), MEPS releasing the data from patients (August 2021), and the ClinCalc DrugStats release (a few months later, classified as the 2022 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.2. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Jul 3, 2021
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