The Top 300 of 2021

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2021

Rank Drug Name Total Prescriptions (2021) Total Patients (2021) Annual Change
1 Atorvastatin 116,702,335 28,111,470 0
2 Metformin 91,151,043 19,883,763  1
3 Levothyroxine 89,309,050 19,064,382  1
4 Lisinopril 88,272,557 20,475,892 0
5 Amlodipine 73,569,606 17,734,288 0
6 Metoprolol 65,529,551 15,535,072 0
7 Albuterol 61,469,064 18,070,429 0
8 Losartan 55,245,074 13,363,279  1
9 Omeprazole 54,561,969 13,900,115  1
10 Gabapentin 47,125,973 10,697,239 0
11 Sertraline 39,206,397 8,478,900  1
12 Hydrochlorothiazide 39,038,822 9,665,980  1
13 Rosuvastatin 32,632,145 8,006,428  4
14 Montelukast 30,996,712 7,119,519 0
15 Escitalopram 30,505,719 6,499,379 0
16 Simvastatin 30,492,289 7,839,909  3
17 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 30,371,088 3,990,803  5
18 Bupropion 29,099,445 6,412,363 0
19 Pantoprazole 27,347,488 7,310,342  1
20 Acetaminophen; Hydrocodone 26,599,439 8,616,204  4
21 Furosemide 26,376,404 6,473,988  2
22 Trazodone 26,310,083 5,322,910  1
23 Fluticasone 25,283,015 7,859,173 0
24 Tamsulosin 23,540,060 6,474,672 0
25 Fluoxetine 22,686,838 4,764,311 0
26 Carvedilol 21,782,177 5,039,099 0
27 Duloxetine 20,012,841 4,444,533 0
28 Prednisone 19,898,457 8,660,906  2
29 Insulin Glargine 19,873,255 3,901,230  3
30 Potassium Chloride 18,543,551 4,479,822  3
31 Citalopram 18,444,405 4,126,597 0
32 Meloxicam 18,226,904 5,819,321  4
33 Apixaban 17,933,195 4,021,147  15
34 Aspirin 17,686,612 5,286,487  2
35 Ergocalciferol 17,179,725 5,191,630  11
36 Ibuprofen 17,043,550 8,701,817  2
37 Clopidogrel 16,723,608 4,187,295  8
38 Amoxicillin 16,657,138 13,130,571  2
39 Pravastatin 15,936,065 3,917,270  5
40 Allopurinol 15,706,780 3,768,723  2
41 Tramadol 15,446,495 5,026,719  6
42 Alprazolam 15,380,320 3,325,555  5
43 Methylphenidate 15,282,088 2,440,779  2
44 Venlafaxine 15,122,966 3,008,776  1
45 Cyclobenzaprine 14,426,039 5,107,046  6
46 Clonazepam 14,197,547 2,352,995  2
47 Atenolol 14,107,487 3,384,297  6
48 Glipizide 13,998,178 3,402,458  1
49 Cetirizine 13,929,421 4,000,093  3
50 Lamotrigine 13,244,443 1,957,025  12
51 Hydrochlorothiazide; Lisinopril 12,908,559 3,026,424  1
52 Ethinyl Estradiol; Norethindrone 12,906,438 2,753,719  7
53 Buspirone 12,694,068 2,644,397  2
54 Spironolactone 12,688,242 3,146,100  3
55 Insulin Lispro 12,035,959 2,270,527  16
56 Warfarin 11,785,098 2,244,265  2
57 Famotidine 11,668,047 3,867,415  9
58 Hydroxyzine 11,643,508 3,392,983  12
59 Oxycodone 11,552,448 4,150,118  5
60 Estradiol 11,382,723 2,864,047  1
61 Diclofenac 11,037,695 4,112,922  11
62 Quetiapine 10,957,922 1,809,254  2
63 Zolpidem 10,838,845 2,402,662  16
64 Fluticasone; Salmeterol 10,678,059 2,794,066  8
65 Cholecalciferol 10,583,900 3,367,693  5
66 Topiramate 10,042,403 2,069,817  9
67 Loratadine 9,990,364 2,515,720  6
68 Latanoprost 9,895,398 2,753,023  9
69 Lisdexamfetamine 9,835,531 1,450,419  16
70 Dulaglutide 9,599,734 1,926,282  26
71 Insulin Aspart 9,568,330 2,082,384  9
72 Budesonide; Formoterol 9,505,098 2,322,938  11
73 Pregabalin 8,996,019 1,687,032  5
74 Glimepiride 8,994,560 2,066,583  13
75 Acetaminophen; Oxycodone 8,987,786 2,612,150  6
76 Ethinyl Estradiol; Norgestimate 8,963,409 2,283,373  13
77 Folic Acid 8,892,870 2,343,374  10
78 Lorazepam 8,860,599 2,204,460  13
79 Ondansetron 8,790,270 4,741,786  4
80 Clonidine 8,613,722 1,835,614  5
81 Fenofibrate 8,600,833 2,043,475  14
82 Doxycycline 8,599,224 4,431,691  3
83 Sitagliptin 8,556,031 1,865,004  9
84 Diltiazem 8,522,821 2,091,547  8
85 Empagliflozin 8,480,340 2,159,608  17
86 Rivaroxaban 8,330,556 1,772,808 0
87 Hydrochlorothiazide; Losartan 8,266,619 2,268,307  6
88 Finasteride 8,254,453 2,480,881  2
89 Tizanidine 8,192,389 2,238,146  5
90 Semaglutide 8,153,559 1,959,322  39
91 Propranolol 7,993,156 2,008,047  3
92 Ezetimibe 7,646,574 2,047,338  8
93 Naproxen 7,592,556 3,530,473  2
94 Alendronate 7,482,354 2,145,965 0
95 Paroxetine 7,482,340 1,614,935  13
96 Cephalexin 7,322,464 4,945,408  5
97 Azithromycin 7,308,877 5,781,665  29
98 Celecoxib 7,082,350 1,967,573 0
99 Aripiprazole 6,805,675 1,400,604  10
100 Lovastatin 6,673,173 1,587,134  1
101 Levetiracetam 6,633,071 1,377,442  9
102 Oxybutynin 6,619,470 1,711,957  5
103 Baclofen 6,516,375 1,635,619  5
104 Triamcinolone 6,413,003 4,010,734  2
105 Ferrous Sulfate 6,320,872 2,164,663  11
106 Hydralazine 6,234,195 1,624,406  3
107 Amitriptyline 5,923,315 1,353,110  26
108 Fluticasone; Vilanterol 5,918,773 1,171,764  7
109 Sumatriptan 5,873,389 1,747,757  2
110 Cyanocobalamin 5,825,048 1,663,130  5
111 Isosorbide 5,601,959 1,436,412  3
112 Hydrochlorothiazide; Triamterene 5,428,906 1,392,875  19
113 Acetaminophen 5,327,155 2,796,327  5
114 Valacyclovir 5,268,219 2,165,806  5
115 Amoxicillin; Clavulanate 5,236,139 4,264,890  8
116 Hydroxychloroquine 5,222,102 1,329,229  10
117 Insulin Detemir 5,214,067 1,027,442  7
118 Clindamycin 5,194,038 2,949,885  7
119 Thyroid 5,159,236 1,012,361  2
120 Valsartan 5,151,116 1,457,484  3
121 Dexmethylphenidate 4,936,398 632,395  9
122 Sulfamethoxazole; Trimethoprim 4,905,134 3,199,276  1
123 Methocarbamol 4,798,559 1,797,747  4
124 Mirtazapine 4,752,292 1,063,153  20
125 Esomeprazole 4,673,931 1,068,821  3
126 Olmesartan 4,581,362 1,173,921  13
127 Chlorthalidone 4,577,162 1,281,201  6
128 Nifedipine 4,567,479 1,237,401  7
129 Pioglitazone 4,526,638 1,045,883  39
130 Oxcarbazepine 4,492,392 759,481  14
131 Donepezil 4,435,098 1,278,743  19
132 Methotrexate 4,402,317 912,086  19
133 Docusate 4,393,499 1,683,774  30
134 Tiotropium 4,361,799 975,405  24
135 Nitrofurantoin 4,327,699 2,493,318  32
136 Meclizine 4,269,435 1,648,602  6
137 Desogestrel; Ethinyl Estradiol 4,229,811 894,531  17
138 Risperidone 4,225,629 584,233 0
139 Nortriptyline 4,183,946 903,333  16
140 Norethindrone 4,164,058 1,311,480  3
141 Ciprofloxacin 4,147,677 2,735,003  9
142 Ropinirole 4,102,324 853,008  14
143 Testosterone 4,021,439 839,946  29
144 Ethinyl Estradiol; Levonorgestrel 4,016,121 1,376,728  15
145 Azelastine 4,011,208 1,350,513  28
146 Insulin Degludec 4,009,540 878,698  10
147 Benazepril 3,932,101 1,056,395  6
148 Dicyclomine 3,919,946 1,194,528  1
149 Diazepam 3,898,003 1,247,334  21
150 Amlodipine; Benazepril 3,883,604 933,017  19
151 Albuterol; Ipratropium 3,876,201 858,352  1
152 Drospirenone; Ethinyl Estradiol 3,875,387 859,872  7
153 Prednisolone 3,816,335 2,269,683 0
154 Metformin; Sitagliptin 3,755,407 784,043 0
155 Valproate 3,633,026 713,499  46
156 Morphine 3,629,439 704,840  16
157 Sildenafil 3,613,743 1,365,796  26
158 Benzonatate 3,569,507 2,046,763  1
159 Rizatriptan 3,505,154 886,004  25
160 Brimonidine 3,470,855 748,650  15
161 Ketoconazole 3,429,167 1,987,923  9
162 Clobetasol 3,428,139 1,849,660  9
163 Timolol 3,406,225 872,159  20
164 Olanzapine 3,347,385 600,079 0
165 Fluconazole 3,276,721 2,070,358  9
166 Liraglutide 3,264,900 784,141  20
167 Progesterone 3,257,570 804,553  9
168 Methylprednisolone 3,254,222 2,413,471  7
169 Acyclovir 3,250,033 1,058,857  7
170 Memantine 3,238,256 809,403  18
171 Tadalafil 3,167,761 757,242  90
172 Irbesartan 3,148,185 744,799  24
173 Fluticasone; Umeclidinium; Vilanterol 2,927,505 668,594  51
174 Nitroglycerin 2,842,773 1,169,220  9
175 Cyclosporine 2,802,769 871,693  37
176 Acetaminophen; Codeine 2,794,323 1,367,664  11
177 Gemfibrozil 2,791,706 635,078  12
178 Desvenlafaxine 2,781,884 534,265  2
179 Insulin Human; Insulin Isophane Human 2,768,890 557,473  67
180 Torsemide 2,753,009 530,362  33
181 Calcium Phosphate; Cholecalciferol 2,734,077 702,638  34
182 Anastrozole 2,728,845 573,970  2
183 Prazosin 2,692,449 512,048  7
184 Colchicine 2,646,595 963,808  57
185 Budesonide 2,617,796 858,977  22
186 Sucralfate 2,616,503 840,715  4
187 Dapagliflozin 2,607,169 715,994  30
188 Promethazine 2,595,247 965,521  20
189 Sacubitril; Valsartan 2,591,806 558,518  30
190 Levocetirizine 2,550,953 725,643  11
191 Dorzolamide; Timolol 2,518,853 788,637  4
192 Hydrocortisone 2,459,727 1,415,290  43
193 Lurasidone 2,433,438 385,353  66
194 Metronidazole 2,380,724 1,315,654  28
195 Doxazosin 2,340,070 593,551  14
196 Verapamil 2,339,847 580,801  45
197 Cefdinir 2,335,533 1,770,777  31
198 Ethinyl Estradiol; Etonogestrel 2,334,719 658,337  4
199 Liothyronine 2,325,739 478,880  19
200 Mirabegron 2,324,745 648,744  40
201 Ramipril 2,305,401 637,126  5
202 Dorzolamide 2,277,156 516,653  14
203 Mupirocin 2,274,043 1,802,051 0
204 Bimatoprost 2,257,784 579,256  38
205 Flecainide 2,199,319 572,389  17
206 Tretinoin 2,167,095 1,255,617  24
207 Phentermine 2,142,309 750,476  26
208 Temazepam 2,139,735 509,034  15
209 Pramipexole 2,126,160 535,282  16
210 Ketorolac 2,124,922 1,059,796  39
211 Magnesium Salts 2,102,185 544,993  9
212 Umeclidinium; Vilanterol 2,042,595 441,676  42
213 Labetalol 2,019,527 507,522  3
214 Glyburide 2,018,968 458,067  14
215 Formoterol; Mometasone 1,992,684 432,955  73
216 Lansoprazole 1,970,097 568,862  25
217 Telmisartan 1,954,206 481,997  31
218 Omega-3-acid Ethyl Esters 1,948,775 573,754  19
219 Atomoxetine 1,948,141 364,455  68
220 Ranolazine 1,910,445 482,386  38
221 Epinephrine 1,896,954 1,432,804  30
222 Letrozole 1,896,630 438,894  35
223 Levofloxacin 1,889,630 1,010,959  17
224 Hydrochlorothiazide; Valsartan 1,871,393 522,202  11
225 Vitamin E 1,844,043 760,854  136
226 Polyethylene Glycol 3350 1,831,598 804,489 0
227 Ethinyl Estradiol; Norgestrel 1,826,599 304,654  89
228 Solifenacin 1,791,635 485,019  38
229 Minocycline 1,787,930 554,000  7
230 Sodium Salts 1,782,361 716,106  44
231 Guanfacine 1,771,668 217,367  69
232 Acetaminophen; Butalbital; Caffeine 1,757,901 642,312  31
233 Nystatin 1,737,715 912,611  6
234 Terazosin 1,729,966 492,399  23
235 Amiodarone 1,713,448 473,164  37
236 Adalimumab 1,690,110 322,011  31
237 Methimazole 1,687,616 553,987  31
238 Medroxyprogesterone 1,675,969 522,666  24
239 Mesalamine 1,672,097 444,846  55
240 Ofloxacin 1,596,736 1,291,221  2
241 Digoxin 1,594,792 393,825  4
242 Diphenhydramine 1,573,897 330,187  50
243 Calcium 1,573,203 537,153 0
244 Nebivolol 1,554,152 446,018  5
245 Terbinafine 1,545,067 800,034  34
246 Linaclotide 1,515,562 449,902  2
247 Chlorhexidine 1,513,289 920,250  26
248 Pancrelipase Amylase; Pancrelipase Lipase; Pancrelipase Protease 1,429,785 265,428  14
249 Fluocinonide 1,402,661 772,594  31
250 Nabumetone 1,401,463 423,505  68
251 Betamethasone 1,389,641 713,755  18
252 Carbidopa; Levodopa 1,375,525 220,845  112
253 Indomethacin 1,374,642 533,139  67
254 Naltrexone 1,343,280 429,014  47
255 Ascorbic Acid 1,330,392 542,050  59
256 Penicillin V 1,328,966 873,254  63
257 Melatonin 1,289,851 452,589  41
258 Calcitriol 1,275,071 332,043  19
259 Erythromycin 1,274,917 962,693  34
260 Dexamethasone 1,263,065 831,486  12
261 Hydromorphone 1,243,299 407,512  11
262 Fexofenadine 1,232,280 445,752  7
263 Olopatadine 1,215,595 779,221  5
264 Isotretinoin 1,199,278 473,970 0
265 Lactulose 1,164,694 424,071  107
266 Mometasone 1,163,500 590,984  35
267 Lidocaine 1,115,403 647,276  70
268 Beclomethasone 1,102,078 373,012  48
269 Ipratropium 1,074,165 400,930  43
270 Sennosides 1,034,701 475,307  21
271 Ciclopirox 976,971 569,640  60
272 Hyoscyamine 972,819 421,879  70
273 Clotrimazole 959,021 474,043  53
274 Betamethasone; Clotrimazole 958,479 719,946  34
275 Senna; Docusate 858,475 433,676  87
276 Ethinyl Estradiol; Ethynodiol 854,356 119,158  148
277 Drospirenone; Ethinyl Estradiol; Levomefolate 840,357 109,562  73
278 Enalapril 832,753 190,679  51
279 Fexofenadine; Pseudoephedrine 829,015 434,981  102
280 Cyproheptadine 814,171 236,080  53
281 Fluorouracil 807,188 642,581  30
282 Hydroquinone 802,769 545,703  85
283 Fish Oil 790,925 221,585  86
284 Benzoyl Peroxide 787,534 276,831  87
285 Phenazopyridine 781,559 538,939  63
286 Moxifloxacin 713,971 416,490  48
287 Loperamide 703,673 310,789  43
288 Guaifenesin 695,138 323,235  36
289 Dextromethorphan; Promethazine 627,117 501,947  62
290 Imiquimod 622,392 437,790  78
291 Sodium Fluoride 614,873 269,633  26
292 Oxymetazoline 608,917 298,517  127
293 Atropine; Diphenoxylate 608,611 210,671  28
294 Brompheniramine; Dextromethorphan; Pseudoephedrine 584,348 525,735  65
295 Polyethylene Glycol 3350 With Electrolytes 552,075 475,245  43
296 Tacrolimus 549,984 431,211  64
297 Codeine; Guaifenesin 542,422 459,999  80
298 Vitamin A 525,987 81,083 0
299 Tobramycin 501,041 406,098  77
300 Bacitracin 498,302 158,742  121

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2022 calendar year), MEPS releasing the data from patients (August 2024), and the ClinCalc DrugStats release (a few months later, classified as the 2022 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Which of these drugs causes acute kidney injury? The Top 250 Drugs by ClinCalc Academy
 
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Updated Sep 12, 2021
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