The Top 300 of 2019

Provided by the ClinCalc DrugStats Database

The Top 300 Drugs of 2019

Rank Drug Name Total Prescriptions (2016) Annual Change
1 Levothyroxine 114,344,324  1
2 Lisinopril 110,611,324  1
3 Atorvastatin 96,942,508 0
4 Metformin Hydrochloride 81,305,415 0
5 Amlodipine Besylate 75,201,622  2
6 Metoprolol 74,019,645  2
7 Omeprazole 70,626,980  1
8 Simvastatin 65,144,488  3
9 Losartan Potassium 49,281,054  3
10 Albuterol 47,109,711 0
11 Gabapentin 44,154,514  2
12 Hydrochlorothiazide 43,472,270  1
13 Acetaminophen; Hydrocodone Bitartrate 43,109,574  4
14 Sertraline Hydrochloride 37,105,238 0
15 Furosemide 32,692,726 0
16 Fluticasone 29,899,932  8
17 Acetaminophen 29,325,845  1
18 Amoxicillin 28,117,284  1
19 Alprazolam 27,030,725  4
20 Atenolol 26,739,322  3
21 Citalopram 26,387,590 0
22 Insulin Glargine 26,201,314  14
23 Montelukast 25,326,687  7
24 Trazodone Hydrochloride 25,300,258  2
25 Pantoprazole Sodium 25,270,699  4
26 Escitalopram Oxalate 25,240,490  5
27 Pravastatin Sodium 24,666,149  9
28 Bupropion 23,811,613  3
29 Fluoxetine Hydrochloride 23,729,286  9
30 Carvedilol 23,338,866  4
31 Prednisone 23,242,849  1
32 Tamsulosin Hydrochloride 22,533,461  13
33 Potassium 22,380,348  6
34 Clopidogrel Bisulfate 21,398,662  6
35 Ibuprofen 21,329,751  1
36 Meloxicam 21,290,692  1
37 Rosuvastatin Calcium 19,917,442  4
38 Aspirin 19,753,190  1
39 Tramadol Hydrochloride 19,479,377  11
40 Zolpidem Tartrate 19,102,809  6
41 Warfarin 18,718,271  1
42 Clonazepam 18,675,679  4
43 Propranolol Hydrochloride 18,416,025  20
44 Glipizide 17,884,980  3
45 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 17,363,796  91
46 Cyclobenzaprine 16,170,425  3
47 Methylphenidate 15,599,244  11
48 Duloxetine 15,377,184 0
49 Azithromycin 15,292,543  4
50 Ranitidine 15,285,992  1
51 Venlafaxine Hydrochloride 15,283,793  1
52 Allopurinol 15,227,146  4
53 Hydrochlorothiazide; Lisinopril 14,862,223  16
54 Oxycodone 14,693,850  2
55 Ethinyl Estradiol; Norethindrone 14,614,505  6
56 Ergocalciferol 14,608,444  9
57 Lorazepam 14,317,316  2
58 Ethinyl Estradiol; Norgestimate 13,426,358  11
59 Estradiol 13,361,413 0
60 Hydrochlorothiazide; Triamterene 12,735,626  11
61 Glimepiride 12,432,147  3
62 Fluticasone Propionate; Salmeterol Xinafoate 12,314,689  11
63 Diltiazem Hydrochloride 12,257,572  12
64 Paroxetine 12,222,861  7
65 Loratadine 12,085,215  3
66 Spironolactone 11,991,114  1
67 Fenofibrate 11,767,185  5
68 Naproxen 11,470,076  1
69 Esomeprazole 11,417,610  3
70 Lamotrigine 11,276,212 0
71 Metronidazole 11,169,357  106
72 Lovastatin 11,000,895  2
73 Alendronate Sodium 10,576,011  8
74 Cetirizine Hydrochloride 10,307,139  2
75 Finasteride 10,300,054  24
76 Clonidine 10,253,268 0
77 Budesonide; Formoterol 10,195,375  17
78 Diclofenac 9,907,530  6
79 Latanoprost 9,879,869  13
80 Hydrochlorothiazide; Losartan Potassium 9,772,428  20
81 Bacitracin; Neomycin; Polymyxin B 9,200,340  8
82 Sitagliptin Phosphate 9,164,964  8
83 Pregabalin 9,074,950  4
84 Insulin Human 8,947,388  40
85 Topiramate 8,846,881  8
86 Quetiapine Fumarate 8,751,996  1
87 Insulin Aspart 8,662,906  2
88 Amitriptyline 8,638,268  5
89 Levetiracetam 8,534,737  29
90 Buspirone Hydrochloride 8,456,948  14
91 Ondansetron 8,450,779  9
92 Valsartan 8,406,000  6
93 Ferrous Sulfate 8,398,923  8
94 Enalapril Maleate 8,342,017  6
95 Tiotropium 8,306,842  9
96 Folic Acid 8,276,080  16
97 Hydroxyzine 8,082,370  2
98 Donepezil Hydrochloride 7,761,701  7
99 Lisdexamfetamine Dimesylate 7,570,687  7
100 Insulin Lispro 7,544,686  16
101 Isosorbide Mononitrate 7,360,509  13
102 Ciprofloxacin 7,192,190  9
103 Cholecalciferol; .Alpha.-Tocopherol 7,114,696  18
104 Benazepril Hydrochloride 7,093,458  15
105 Rivaroxaban 7,058,562  26
106 Sulfamethoxazole; Trimethoprim 6,879,928  33
107 Cephalexin 6,785,958  5
108 Oxybutynin 6,735,604  5
109 Drospirenone; Ethinyl Estradiol 6,681,736  15
110 Doxycycline 6,640,671  1
111 Ropinirole Hydrochloride 6,628,478  36
112 Diazepam 6,606,345  21
113 Hydrocodone Bitartrate 6,591,400  31
114 Amoxicillin; Clavulanate Potassium 6,579,603  36
115 Sumatriptan 6,564,780  20
116 Pioglitazone 6,563,097  10
117 Ethinyl Estradiol; Levonorgestrel 6,441,019  21
118 Tizanidine 6,401,817  10
119 Thyroid 6,363,773  69
120 Celecoxib 6,269,150  11
121 Insulin Detemir 6,227,661  14
122 Triamcinolone 6,077,301  29
123 Apixaban 5,833,149  62
124 Baclofen 5,708,865  14
125 Famotidine 5,702,253  2
126 Nebivolol Hydrochloride 5,686,450  24
127 Docusate 5,585,832  30
128 Mirtazapine 5,547,697  11
129 Divalproex Sodium 5,484,270  9
130 Verapamil Hydrochloride 5,424,766  16
131 Aripiprazole 5,186,998  2
132 Gemfibrozil 5,068,993  20
133 Desogestrel; Ethinyl Estradiol 5,062,634  39
134 Hydrochlorothiazide; Valsartan 5,000,778  9
135 Hydroxychloroquine Sulfate 4,965,681  3
136 Prednisolone 4,942,861  8
137 Cyanocobalamin 4,941,184  25
138 Hydralazine Hydrochloride 4,888,742  21
139 Omega-3-acid Ethyl Esters 4,841,513  14
140 Amlodipine Besylate; Benazepril Hydrochloride 4,829,728  30
141 Lansoprazole 4,805,894  4
142 Timolol 4,684,226  50
143 Hydrocortisone 4,634,998  2
144 Ezetimibe 4,570,245  41
145 Digoxin 4,470,645  3
146 Testosterone 4,413,016  24
147 Memantine Hydrochloride 4,388,334  28
148 Methylprednisolone 4,382,399  20
149 Estrogens, Conjugated 4,245,842  18
150 Adalimumab 4,245,501  39
151 Clindamycin 4,223,619  22
152 Methotrexate 4,208,091  98
153 Ramipril 4,206,514  31
154 Nifedipine 4,152,353  31
155 Methylcellulose (4000 Mpa.S) 4,092,001 0
156 Guanfacine 4,022,949  27
157 Doxazosin Mesylate 4,010,324  1
158 Morphine 3,989,646  43
159 Risperidone 3,975,563  29
160 Promethazine Hydrochloride 3,928,732  20
161 Levofloxacin 3,910,492  1
162 Meclizine Hydrochloride 3,906,199  7
163 Levocetirizine Dihydrochloride 3,868,302  63
164 Olmesartan Medoxomil 3,805,975  22
165 Mometasone 3,780,867  31
166 Albuterol Sulfate; Ipratropium Bromide 3,774,880  23
167 Brimonidine Tartrate 3,764,084  12
168 Valacyclovir 3,730,423  10
169 Terazosin 3,728,582  3
170 Solifenacin Succinate 3,630,386  11
171 Irbesartan 3,615,078  9
172 Glyburide 3,591,159  23
173 Fluconazole 3,553,998  27
174 Chlorthalidone 3,551,730  19
175 Carbidopa; Levodopa 3,535,782  28
176 Beclomethasone 3,519,550  28
177 Polyethylene Glycol 3350 3,503,811  14
178 Dicyclomine Hydrochloride 3,502,152  12
179 Magnesium 3,473,024 0
180 Nitroglycerin 3,472,539  39
181 Carisoprodol 3,405,849  33
182 Ipratropium 3,400,104  35
183 Calcium; Cholecalciferol 3,381,006  15
184 Clobetasol Propionate 3,335,235  17
185 Temazepam 3,235,550  11
186 Nitrofurantoin 3,232,274  6
187 Methocarbamol 3,229,264  22
188 Liraglutide 3,225,863  6
189 Progesterone 3,173,331  43
190 Dexlansoprazole 3,153,131  22
191 Metformin Hydrochloride; Sitagliptin Phosphate 3,150,401  34
192 Nortriptyline Hydrochloride 3,131,539  15
193 Benzonatate 3,104,318  12
194 Canagliflozin 3,102,040  33
195 Acyclovir 3,078,845  31
196 Linagliptin 3,058,866  23
197 Carbamazepine 2,982,030  65
198 Amiodarone Hydrochloride 2,934,681  1
199 Mupirocin 2,833,713  19
200 Dorzolamide Hydrochloride; Timolol Maleate 2,794,085  33
201 Phenytoin 2,751,980  43
202 Acetaminophen; Butalbital 2,737,411  9
203 Formoterol Fumarate; Mometasone Furoate 2,695,094  26
204 Pramipexole Dihydrochloride 2,674,073  17
205 Ketoconazole 2,654,870  41
206 Naphazoline Hydrochloride; Pheniramine Maleate 2,652,550  2
207 Budesonide 2,634,694  53
208 Quinapril 2,610,034  16
209 Dexmethylphenidate Hydrochloride 2,575,619  30
210 Diphenhydramine Hydrochloride 2,570,291  11
211 Benztropine Mesylate 2,568,272  2
212 Hydromorphone Hydrochloride 2,544,721  81
213 Cyclosporine 2,544,291  4
214 Ethinyl Estradiol; Etonogestrel 2,529,179  15
215 Sodium Fluoride 2,524,181  9
216 Lidocaine 2,514,857  22
217 Nystatin 2,464,584  43
218 Fentanyl 2,450,838  4
219 Azathioprine 2,439,027  80
220 Prazosin Hydrochloride 2,432,201  25
221 Sodium 2,421,240  37
222 Lithium 2,384,997  49
223 Levonorgestrel 2,364,900  181
224 Anastrozole 2,341,266  33
225 Olanzapine 2,340,233  5
226 Phentermine 2,295,160  31
227 Lurasidone Hydrochloride 2,237,906  82
228 Cefdinir 2,232,167  1
229 Minocycline Hydrochloride 2,211,329  26
230 Chlorhexidine 2,208,570  62
231 Calcitriol 2,204,064  16
232 Rizatriptan Benzoate 2,181,213  79
233 Labetalol 2,147,724  2
234 Torsemide 2,146,198  20
235 Penicillin V 2,139,402  4
236 Sucralfate 2,132,255  15
237 Primidone 2,115,922  57
238 Tamoxifen Citrate 2,097,599  4
239 Doxepin Hydrochloride 2,084,468  64
240 Mesalamine 2,055,242  69
241 Guaifenesin; Codeine Phosphate; Pseudoephedrine Hydrochloride 2,050,185 0
242 Sildenafil 2,038,392  17
243 Haloperidol 2,032,944  46
244 Oxcarbazepine 2,009,881  68
245 Atomoxetine Hydrochloride 2,008,742  47
246 Telmisartan 1,989,675  61
247 Calcium 1,970,435  51
248 Travoprost 1,891,621  46
249 Oseltamivir Phosphate 1,891,220  13
250 Metoclopramide Hydrochloride 1,877,952  36
251 Colchicine 1,877,197  4
252 Medroxyprogesterone Acetate 1,850,807  47
253 Epinephrine 1,844,097  61
254 Bimatoprost 1,818,954  1
255 Pancrelipase Lipase; Pancrelipase Protease; Pancrelipase Amylase 1,812,528  61
256 Loperamide Hydrochloride 1,796,511  80
257 Liothyronine Sodium 1,767,035 0
258 Hydrochlorothiazide; Olmesartan Medoxomil 1,764,804  17
259 Dexamethasone 1,753,091  23
260 Vortioxetine Hydrobromide 1,728,600 0
261 Guaifenesin 1,701,514  38
262 Atenolol; Chlorthalidone 1,690,330  18
263 Mirabegron 1,684,129  52
264 Cilostazol 1,673,308  48
265 Norethindrone 1,666,057 0
266 Bumetanide 1,660,786 0
267 Azelastine Hydrochloride 1,658,902  6
268 Dabigatran Etexilate Mesylate 1,656,539  58
269 Olopatadine 1,638,167  41
270 Sotalol Hydrochloride 1,635,136  22
271 Dorzolamide Hydrochloride 1,634,651  7
272 Desvenlafaxine 1,633,939  34
273 Flecainide Acetate 1,627,682  27
274 Dutasteride 1,617,765  13
275 Methimazole 1,602,862  26
276 Ranolazine 1,520,475  24
277 Niacin 1,502,762  52
278 Vilazodone Hydrochloride 1,502,018  41
279 Terbinafine 1,492,179  8
280 Tadalafil 1,491,002  22
281 Erythromycin 1,489,921 0
282 Bisoprolol Fumarate 1,473,454  19
283 Nadolol 1,453,528  1
284 Modafinil 1,452,935  46
285 Rabeprazole Sodium 1,432,202 0
286 Eszopiclone 1,431,803  52
287 Sennosides 1,407,848  3
288 Prochlorperazine 1,402,174  10
289 Empagliflozin 1,397,988 0
290 Neomycin; Polymyxin B; Hydrocortisone 1,375,127  76
291 Cefuroxime 1,324,553  80
292 Amphetamine 1,323,762  238
293 Exenatide 1,311,922  29
294 Raloxifene Hydrochloride 1,280,083  38
295 Enoxaparin Sodium 1,272,928  53
296 Ketorolac Tromethamine 1,271,945  28
297 Tretinoin 1,249,141  35
298 Atropine Sulfate; Diphenoxylate Hydrochloride 1,247,813  22
299 Ofloxacin 1,232,863  7
300 Tolterodine Tartrate 1,214,561  22

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2016 calendar year), MEPS releasing the data from patients (August 2018), and the ClinCalc DrugStats release (a few months later, classified as the 2019 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2006-2016. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 19.1. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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