Codeine; Guaifenesin

Drug Usage Statistics, United States, 2013 - 2021

Codeine; Guaifenesin Summary for 2021

Top drug rank #297 ( 80)
Estimated number of prescriptions in the United States (2021) 542,422
Estimated number of patients in the United States (2021) 459,999
Average total drug cost (USD)  
Per prescription $16.41
Per day of therapy $3.58/day
Average out-of-pocket cost (USD)  
Per prescription $8.04
Per day of therapy $1.45/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 227  229
2014 260  33
2015 197  63
2016 226  29
Year Rank Change
2017 208  18
2018 218  10
2019 309  91
2020 377  68
2021 297  80

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

No data available

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Acetaminophen; Hydrocodone 26,599,439
Tramadol 15,446,495
Oxycodone 11,552,449
Acetaminophen; Oxycodone 8,987,786
Morphine 3,629,439
Acetaminophen; Codeine 2,794,323
Hydromorphone 1,243,299
Loperamide 703,674
Guaifenesin 695,138
Codeine; Guaifenesin (this drug) 542,423
Hydrocodone 286,675
Dextromethorphan; Guaifenesin 139,469
Chlorpheniramine; Hydrocodone 52,828
Homatropine; Hydrocodone 42,774
Chlorpheniramine; Codeine; Phenylephrine 12,423
Brompheniramine; Codeine; Phenylephrine 5,924
Pseudoephedrine; Codeine; Guaifenesin 2,532

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Cheratussin AC
  • Codeine Guaifenesin
  • Codeine-guaifenesin
  • G Tussin AC
  • Guaiatussin AC
  • M-clear
  • Maxi-tuss AC
  • Virtussin A/C
  • Virtussin AC
  • Virtussin AC W/Alc
Generic Drug Synonyms and Salts
  • Codeine Phosphate; Guaifenesin
  • Guaifenesin; Codeine
  • Guaifenesin; Codeine Phosphate
  • Codeine; Guaifenesin

FDA Approval Information

Established Pharmacologic Class (EPC): Expectorant, Opioid Agonist
Initial FDA approval date: 10/1/2006
First FDA applicant: Proficient Rx Lp
First dosage form: Solution (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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