Dextromethorphan; Guaifenesin

Drug Usage Statistics, United States, 2014 - 2024

Dextromethorphan; Guaifenesin Summary for 2024

Top drug rank	#357 ( 42)
Estimated number of prescriptions in the United States (2024)	45,121
Estimated number of patients in the United States (2024)	45,121

Average total drug cost (USD)
Per prescription	$19.77
Per day of therapy	$5.22/day
Average out-of-pocket cost (USD)
Per prescription	$5.46
Per day of therapy	$0.62/day

Total Prescriptions and Patients Per Year (2014 - 2024)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2014	387	4
2015	403	16
2016	389	14
2017	393	4
2018	418	25
2019	382	36

Year	Rank	Change
2020	344	38
2021	337	7
2022	290	47
2023	315	25
2024	357	42

Drug Cost Over Time (2014 - 2024)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2024)

No data available

Distribution of Days Supplied (2024)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2024)
Dextromethorphan; Promethazine	1,773,420
Codeine; Guaifenesin	1,017,179
Brompheniramine; Dextromethorphan; Pseudoephedrine	702,500
Guaifenesin	391,105
Dextromethorphan	326,898
Dextromethorphan; Triprolidine	79,404
Chlorpheniramine; Dextromethorphan; Phenylephrine	69,747
Dextromethorphan; Guaifenesin (this drug)	45,121
Brompheniramine; Dextromethorphan; Phenylephrine	28,853
Dexbrompheniramine; Dextromethorphan; Phenylephrine	19,157
Dextromethorphan; Guaifenesin; Phenylephrine	18,373
Dextromethorphan; Phenylephrine; Pyrilamine	17,542
Dextromethorphan; Guaifenesin; Pseudoephedrine	6,963
Guaifenesin; Phenylephrine	3,269
Dextromethorphan; Phenylephrine; Triprolidine	2,319

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Amazon Basic Care Mucus DM
Basic Care Mucus DM
Berkley And Jensen Mucus Relief DM
Bisolvine
Carolina Crud Crusher
Childrens Giltuss Honey Cough And Chest Congestion
Cough And Chest Congestion Maximum Strength
Cough And Congestion Extended Release
Defensol Adult Syrup
DG Health Mucus DM
DR Kids
Equaline Mucus DM
Exchange Select Mucus DM
Giltuss Childrens Cough And Chest Congestion
Giltuss Diabetic
Giltuss Hbp Cough And Chest Congestion
Giltuss Honey Cough And Chest Congestion
Good Neighbor Pharmacy Mucus DM
Good Sense Mucus DM
Guaifed DM
Guaifenesin And Dextromethorphan Hydrobromide
Guaifenesin And Dextromethorphan Hydrobromide Hbr
Guaifenesin DM
Kids Cough And Chest Congestion
Maximum Strength Cough And Congestion Extended Release
Maximum Strength Mucus DM Extended Release
Maximum Strength Mucus Relief DM
Members Mark Mucus Relief DM
Mucinex DM
Mucinex DM, Cvp Health
Mucinex DM, Travel Basix
Mucinex Fast-max
Mucinex Fast-max Kickstart Severe Congestion And Cough
Mucolyte
Mucosa DM
Mucus DM
Mucus DM Extended Release
Mucus Relief DM
Mucus Relief DM Expectorant And Cough Suppressant
Mucus Relief DM Expectorant And Cough Suppressant Maximum Strength
Mucus Relief DM Extended Release Caplets
Mucus Relief DM Max
Mucus Relief DM Maximum Strength
Mucus Relief Xpect
Neotuss S/F
Pharbinex-DM
Revasol Tussin DM Max With Honey
Rugby Mucus Relief DM ER
Sanatos Children Cough And Congestion Cherry
Sanatos Mucus Relief Cold Toddlers
Supress DM
Topcare Mucus DM
Tussin DM
Vanacof XP Cough / Chest Congestion

Generic Drug Synonyms and Salts

Dextromethorphan Hydrobromide; Guaifenesin
Guaifenesin; Dextromethorphan Hydrobromide
Dextromethorphan; Guaifenesin

FDA Approval Information

Established Pharmacologic Class (EPC):	Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Initial FDA approval date:	4/29/2004
First FDA applicant:	Otc
First dosage form:	Tablet, Extended Release (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2024. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2026.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Apr 15, 2025

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Dextromethorphan; Guaifenesin

Drug Usage Statistics, United States, 2014 - 2024

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