Opioid Agonist

Established Pharmacologic Class (EPC) Comparison, United States, 2021

Total Prescriptions in (2021)

Drug Name Total Prescriptions (2021) Percent Share
Acetaminophen; Hydrocodone 26,599,439 37%
Tramadol 15,446,495 21.5%
Oxycodone 11,552,449 16.1%
Acetaminophen; Oxycodone 8,987,786 12.5%
Morphine 3,629,439 5%
Acetaminophen; Codeine 2,794,323 3.9%
Hydromorphone 1,243,299 1.7%
Loperamide 703,674 1%
Codeine; Guaifenesin 542,423 0.8%
Hydrocodone 286,675 0.4%
Chlorpheniramine; Hydrocodone 52,828 0.1%
Homatropine; Hydrocodone 42,774 0.1%
Chlorpheniramine; Codeine; Phenylephrine 12,423 0%
Brompheniramine; Codeine; Phenylephrine 5,924 0%
Pseudoephedrine; Codeine; Guaifenesin 2,532 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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