Opioid Agonist

Established Pharmacologic Class (EPC) Comparison, United States, 2022

Total Prescriptions in (2022)

Drug Name Total Prescriptions (2022) Percent Share
Acetaminophen; Hydrocodone 23,521,229 36.9%
Tramadol 12,203,198 19.1%
Oxycodone 11,314,082 17.7%
Acetaminophen; Oxycodone 6,531,256 10.2%
Morphine 4,101,413 6.4%
Acetaminophen; Codeine 3,179,642 5%
Hydromorphone 1,531,449 2.4%
Codeine; Guaifenesin 862,861 1.4%
Loperamide 410,959 0.6%
Homatropine; Hydrocodone 45,484 0.1%
Hydrocodone; Chlorpheniramine 39,773 0.1%
Codeine; Phenylephrine; Promethazine 26,799 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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