Opioid Agonist

Established Pharmacologic Class (EPC) Comparison, United States, 2020

Total Prescriptions in (2020)

Drug Name Total Prescriptions (2020) Percent Share
Acetaminophen; Hydrocodone 30,100,356 37.6%
Tramadol 17,475,420 21.8%
Oxycodone 12,289,519 15.3%
Acetaminophen; Oxycodone 10,086,467 12.6%
Morphine 4,384,337 5.5%
Acetaminophen; Codeine 2,791,618 3.5%
Hydromorphone 1,747,152 2.2%
Loperamide 799,680 1%
Codeine; Guaifenesin 415,672 0.5%
Homatropine; Hydrocodone 49,346 0.1%
Chlorpheniramine; Hydrocodone 13,840 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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