Opioid Agonist

Established Pharmacologic Class (EPC) Comparison, United States, 2020

Total Prescriptions in (2020)

Drug Name	Total Prescriptions (2020)	Percent Share
Acetaminophen; Hydrocodone	30,100,356	37.6%
Tramadol	17,475,420	21.8%
Oxycodone	12,289,519	15.3%
Acetaminophen; Oxycodone	10,086,467	12.6%
Morphine	4,384,337	5.5%
Acetaminophen; Codeine	2,791,618	3.5%
Hydromorphone	1,747,152	2.2%
Loperamide	799,680	1%
Codeine; Guaifenesin	415,672	0.5%
Homatropine; Hydrocodone	49,346	0.1%
Chlorpheniramine; Hydrocodone	13,840	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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