Upper Respiratory Combinations

Multum Therapeutic Class Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Dextromethorphan; Promethazine	1,195,582	27.8%
Codeine; Guaifenesin	972,224	22.6%
Brompheniramine; Dextromethorphan; Pseudoephedrine	748,650	17.4%
Loratadine; Pseudoephedrine	408,298	9.5%
Fexofenadine; Pseudoephedrine	321,775	7.5%
Dextromethorphan; Guaifenesin	215,014	5%
Codeine; Promethazine	139,261	3.2%
Chlorpheniramine; Phenylephrine	82,066	1.9%
Homatropine; Hydrocodone	67,363	1.6%
Chlorpheniramine; Dextromethorphan; Phenylephrine	34,304	0.8%
Brompheniramine; Dextromethorphan; Phenylephrine	29,387	0.7%
Dextromethorphan; Guaifenesin; Phenylephrine	27,074	0.6%
Dextromethorphan; Guaifenesin; Pseudoephedrine	23,464	0.5%
Chlophedianol; Pyrilamine	22,236	0.5%
Hydrocodone; Chlorpheniramine	10,639	0.2%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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