Total phenytoin correction calculator converts a measured total phenytoin level to a corrected total and estimated free level. This calculator accounts for renal dysfunction, serum albumin level, age, and comorbidities.
I receive quite a bit of feedback regarding one of my more popular mobile applications, ICU Trials by ClinCalc. Often, these emails involve a request to add a particular “landmark” trial with the next application update. With 10-20 recent requests for new trial additions, I’ve been forced to re-evaluate my criteria for what constitutes a […]
We’ve been busy at ClinCalc — we’ve officially released four new features on the website, a number of small features, and we’re finishing development on a new mobile application targeted at pharmacy and medical students! Below is an overview of the four newest pages on ClinCalc:
Is there a preferred agent for VTE prophylaxis in trauma patients? Is there a superior dosing strategy for these high-risk patients? The selection and dosing of pharmacologic VTE prophylaxis in trauma patients has a troubled, controversial past. The literature surrounding the topic is riddled with small, conflicting trials and methodological flaws.
The ASPIRE trial, recently published in the NEJM, examined the role of aspirin after patients with VTE’s had completed at least 6 weeks of full anticoagulation (although most completed 6+ months). This is the sister trial to the WARFASA trial, which required 6-18 months of warfarin therapy.
Links Mentioned in Video Online calculator to correct total phenytoin for low albumin: http://clincalc.com/Phenytoin/Correction.aspx Online calculator to correct total phenytoin for concurrent valproic acid: http://clincalc.com/Phenytoin/WithValproicAcid.aspx Video Transcript
How should aspiration pneumonia be treated? Is anaerobic coverage required? The concept of aspiration pneumonia and anaerobic coverage is a complex, controversial topic. Like most controversial topics, there is paucity of evidence, and the literature that does exist is controversial.
Is there a maximum insulin glargine (Lantus) single-injection dose? Anecdotally, I have heard that patients receiving more than 50 units should split the dose from daily dosing to twice-daily. What’s the evidence? The question of a maximum insulin glargine dose is not straightforward because it encompasses several issues:
MIC breakpoints for antimicrobials are not easy to look up — until now. CLSI, the governing body in the United States for breakpoints, hides their data behind a $250+ book called M100. For clinicians who do not work in a microbiology lab or have access to the M100 book, it is difficult to find published […]
Now available on ClinCalc – sample size and post-hoc power calculators! Sample Size Calculator Prior to designing a trial, authors must determine how many subjects should be included in a trial in order to have adequate statistical power. There are a variety of different equations depending on the trial design and the type of outcome […]