NICE-SUGAR Brief Summary – Intensive insulin therapy in the MICU/SICU

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including NICE-SUGAR.

Summary of the NICE-SUGAR Trial

Among critically ill patients, intensive glucose control increased 90-day mortality and the incidence of severe hypoglycemia compared to conventional therapy.

Continue reading

Leuven I Brief Summary – Intensive insulin therapy in the SICU

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including Leuven I.

Summary of the Leuven I (van den Berghe 2002) Trial

In surgical ICU patients (primarily cardiac), intensive insulin therapy reduced ICU mortality, renal impairment, and bloodstream infections. The rate of severe hypoglycemia was higher with intensive insulin.

Continue reading

NINDS Brief Summary – Alteplase within 3 hours for acute ischemic stroke

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including NINDS.

Summary of the NINDS Trial

In patients presenting within 3 hours of ischemic stroke, alteplase improved 3-month neurological function (NNT=9) but did not impact 24-hour symptoms or mortality. In patients receiving alteplase, approximately one-quarter had minor bleeding, and 6.4% had symptomatic ICH (NNH=17).

Continue reading

Kress 2000 Brief Summary – Daily interruption of sedative infusions

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including Kress 2000.

Summary of the Kress 2000 Trial

Medical ICU patients receiving continuous infusion sedation with daily interruption were liberated from mechanical ventilation and left the ICU quicker, but this effect did not translate to a shorter hospital course or a mortality benefit.

Continue reading

EPaNIC Brief Summary – Early vs. late parenteral nutrition

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including EPaNIC.

Summary of the EPaNIC (Casaer 2011) Trial

Early initiation of TPN increased ICU and hospital stay, the incidence of infection, and total healthcare costs. Delaying parenteral nutrition up to 7 days had no effect on mortality.

Continue reading

Rivers 2001 Brief Summary – Early goal-directed therapy for severe sepsis and septic shock

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including Rivers 2001.

Summary of the Rivers 2001 Trial

Protocolized early goal-directed therapy initiated in the ED in severe sepsis and septic shock patients improved resuscitation parameters and reduced mortality.

Continue reading

SOAP-II Brief Summary – Dopamine vs norepinephrine for shock

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including SOAP-II.

Summary of the SOAP-II (De Backer 2010) Trial

Among patients with all types of shock, mortality rates were not different between norepinephrine and dopamine, although norepinephrine was more effective as a vasopressor and was less associated with arrhythmias. Norepinephrine may have a mortality benefit over dopamine in a subset of patients with cardiogenic shock.

Continue reading

ANZICS Dopamine Brief Summary – Renally-dosing dopamine in early renal dysfunction

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including ANZICS Dopamine.

Summary of the ANZICS Dopamine (Bellomo 2001) Trial

The use of “renal dose” dopamine did not reduce peak creatinine, the need for renal replacement therapy, ICU length of stay, or mortality.

Continue reading

Wunderink 2012 Brief Summary – Linezolid vs. vancomycin for MRSA HAP

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including Wunderink 2012.

Summary of the Wunderink 2012 Trial

In a cohort of patients with MRSA pneumonia, linezolid was shown to improve clinical cure rate and cause less nephrotoxicity than vancomycin, but it did not improve 60-day mortality. The findings of this study may have been confounded by unbalanced baseline characteristics.

Continue reading

Bernard 2002 Brief Summary – Australian hypothermia study for out-of-hospital arrest

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including Bernard 2002.

Summary of the Bernard 2002 Trial

Therapeutic hypothermia in patients with out-of-hospital VF arrest improved the incidence of favorable discharge disposition and a trend towards improved mortality.

Continue reading