In the United States, vitamin D supplementation is primarily available as vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Although these two have historically been considered interchangeable and equipotent, the current body of literature strongly supports the preference of Vitamin D3 (cholecalciferol) over D2 (ergocalciferol). Vitamin D2 versus Vitamin D3 Vitamin D3 (cholecalciferol) is produced by […]
We’re releasing a major update to the calculation for our popular vancomycin calculator today. Briefly, the new update implements more advanced calculations when adjusting a vancomycin dose based on a trough level. Drug Elimination during Vancomycin Infusion When adjusting vancomycin based on a trough level, pharmacokinetic textbooks recommend estimating a vancomycin peak level using the […]
ClinCalc.com is proud to announce that ICU Trials by ClinCalc, a mobile application that summarizes landmark critical care trials, has surpassed 100 studies in the app database! With our most recent update on April 18th, the following recent and historic landmark trials were added: MIDEX (2012): Dexmedetomidine vs. midazolam for mechanical ventilation PAC-Man (2005): Efficacy […]
At ClinCalc.com, we’re huge fans of listening and watching educational content at a faster than normal pace. Unfortunately, the video provider used for The Top 250 Drugs (online drug therapy course) does not allow for the ability to change playback speed. If you’re using Google Chrome or Mozilla Firefox, though, you’re in luck! Both web browsers […]
ClinCalc.com has been a bit quiet over the past year. Our Twitter account has been mute, email updates rare, and website updates sparse. Why the radio silence? We’ve been diligently working on an exciting new product for the past year. Quite literally, HUNDREDS of hours have been poured into the conception, creation, and implementation of this amazing new product. […]
The New England Journal of Medicine released three landmark trials this week. Each trial directly addresses controversies in sepsis management that have been debated for a decade or longer: high versus low MAP goals (SEPSISPAM), a challenge to early goal-directed therapy (ProCESS), and albumin replacement (ALBIOS). These trials will undoubtedly have a significant impact on […]
The newest ACC/AHA ASCVD Pooled Cohort Equations has been a very hot topic lately. Our free web-based ASCVD tool and mobile applications have been very well received. A number of ClinCalc readers have asked for a better understanding of the Pooled Cohort Equations — how is an ASCVD calculated? How “strong” is each risk factor? […]
At ClinCalc, we’re very proud to announce the availability of both a web-based 10-year ASCVD Risk Calculator (also termed the Pooled Cohort Equations Calculator). This risk assessment tool is recommended by the newly published 2013 ACC/AHA cholesterol guidelines to estimate 10-year risk of atherosclerotic cardiovascular disease (ASCVD).
We’ve been working hard behind the scenes in preparation for American Pharmacists Month. To celebrate, we’re rolling out four new clinical tools and calculators on ClinCalc.com: Benzodiazepine Equivalence Calculator Enteral and Parenteral Nutrition Summary Number Needed to Treat Odds Ratio to Risk Ratio Conversion
Summary of the Kumar 2006 Trial Among patients with septic shock, every hour of delay in appropriate antibiotic administration was associated with a significant increase in mortality.