Summary of the SOAP-II (De Backer 2010) Trial
Among patients with all types of shock, mortality rates were not different between norepinephrine and dopamine, although norepinephrine was more effective as a vasopressor and was less associated with arrhythmias. Norepinephrine may have a mortality benefit over dopamine in a subset of patients with cardiogenic shock.
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Summary of the ANZICS Dopamine (Bellomo 2001) Trial
The use of “renal dose” dopamine did not reduce peak creatinine, the need for renal replacement therapy, ICU length of stay, or mortality.
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Summary of the Wunderink 2012 Trial
In a cohort of patients with MRSA pneumonia, linezolid was shown to improve clinical cure rate and cause less nephrotoxicity than vancomycin, but it did not improve 60-day mortality. The findings of this study may have been confounded by unbalanced baseline characteristics.
Summary of the Bernard 2002 Trial
Therapeutic hypothermia in patients with out-of-hospital VF arrest improved the incidence of favorable discharge disposition and a trend towards improved mortality.
Summary of the HACA Trial
Therapeutic hypothermia improved 6-month neurologic outcome and mortality among patients with out-of-hospital VT/VF cardiac arrest. Note that hypothermia may be associated with certain complications, such as increased risk of bleeding and infection.
Summary of the CRASH 2 Trial
Tranexamic acid reduced all-cause mortality in a broad population of trauma patients without an increase in vascular occlusion complications.
I receive quite a bit of feedback regarding one of my more popular mobile applications, ICU Trials by ClinCalc. Often, these emails involve a request to add a particular “landmark” trial with the next application update. With 10-20 recent requests for new trial additions, I’ve been forced to re-evaluate my criteria for what constitutes a seminal paper in the area of critical care medicine.
Although there isn’t an official scoring system or absolute list of must-have criteria, I’ve developed a simple list of ten important factors that help differentiate important trials from paramount, landmark gems in evidence-based medicine.
ICU Trials, a mobile app outlining some of the most landmark clinical trials in critical care, is now available for iPhone and Android! Come check out the features and screenshots in all their glory at the ICU Trials for ClinCalc website.