Author Archives: Sean P. Kane

ICU Trials Passes 100 Landmark Studies

Summarized landmark critical care trials on your mobile device

ClinCalc.com is proud to announce that ICU Trials by ClinCalc, a mobile application that summarizes landmark critical care trials, has surpassed 100 studies in the app database!

With our most recent update on April 18th, the following recent and historic landmark trials were added:

  • MIDEX (2012): Dexmedetomidine vs. midazolam for mechanical ventilation
  • PAC-Man (2005): Efficacy of PA catheters in ICU patients
  • FEAST (2011): Fluid boluses in African children with severe infection
  • VSE (2013): Vasopressin, steroids, and epinephrine during cardiac arrest
  • MOPETT (2012): Alteplase for moderate PE
  • Brochard (1994): T-piece, SIMV, or PSV for ventilator weaning

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Speed Up Video Playback of The Top 250 Drugs Online Course

Increase Vimeo playback speed (Chrome extension)

At ClinCalc.com, we’re huge fans of listening and watching educational content at a faster than normal pace. Unfortunately, the video provider used for The Top 250 Drugs (online drug therapy course) does not allow for the ability to change playback speed.

If you’re using Google Chrome or Mozilla Firefox, though, you’re in luck!  Both web browsers have free extensions that allow you to speed up the playback speed of any video, including those on ClinCalc Academy.

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The Top 250 Drugs – Online Pharmacotherapy Video Course

ClinCalc DrugStats Database

ClinCalc.com has been a bit quiet over the past year.  Our Twitter account has been mute, email updates rare, and website updates sparse.

Why the radio silence?

We’ve been diligently working on an exciting new product for the past year.  Quite literally, HUNDREDS of hours have been poured into the conception, creation, and implementation of this amazing new product.  Given this massive undertaking, we’ve kept website and mobile app updates to a minimum in order to expedite our production schedule. Continue reading

Incredible Update to Our Mobile Vancomycin Calculator (Android/iOS)

Vancomycin Calculator for Android and iOS Screenshot

Advanced vancomycin pharmacokinetics equations has never been this easy.

Our original Android-based Vancomycin Calculator was released in July 2011, followed a year later by our iPhone version.  In both mobile technology and the features of the ClinCalc.com website, a lot has changed in the last 2.5+ years.

Today, we’re proud to announce a full redesign of the popular Vancomycin Calculator by ClinCalc on Android and iOS devices. Continue reading

Really NEJM? Shocking Failure of the Peer Review Process for the ALBIOS Trial

Three nuts waiting to be cracked

The New England Journal of Medicine released three landmark trials this week.  Each trial directly addresses controversies in sepsis management that have been debated for a decade or longer: high versus low MAP goals (SEPSISPAM), a challenge to early goal-directed therapy (ProCESS), and albumin replacement (ALBIOS).

These trials will undoubtedly have a significant impact on future sepsis guidelines from SCCM, which is incredibly exciting.  Perhaps even more exciting is to see the dramatic improvement in early sepsis mortality between Rivers in 2001 (30.5 to 46.5%) and ProCESS (18.2 to 21%).

In pouring through each of these trials to provide a timely update to the ICU Trials mobile application, I was absolutely shocked by the failure of the peer review process in the ALBIOS trial.

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Visualizing the ACC/AHA ASCVD Pooled Cohort Equations

ASCVD Pooled Cohort Equations Visualization Tool - By Risk Factor

The newest ACC/AHA ASCVD Pooled Cohort Equations has been a very hot topic lately.  Our free web-based ASCVD tool and mobile applications have been very well received.  A number of ClinCalc readers have asked for a better understanding of the Pooled Cohort Equations — how is an ASCVD calculated?  How “strong” is each risk factor?

To help clinicians understand the new Pooled Cohort Equations, we’ve released a fantastic new visualization and graphing tool.  The tool is intended for the advanced clinician who wants to delve deeper into the equations and visualize the tool in a novel, interactive way.

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New Web-Based 10-Year ASCVD Risk Calculator (Pooled Cohort Equations)

ASCVD Calculator for Android and iOS

 

 

At ClinCalc, we’re very proud to announce the availability of both a web-based 10-year ASCVD Risk Calculator (also termed the Pooled Cohort Equations Calculator).  This risk assessment tool is recommended by the newly published 2013 ACC/AHA cholesterol guidelines to estimate 10-year risk of atherosclerotic cardiovascular disease (ASCVD).

CORTICUS Brief Summary – Hydrocortisone therapy for septic shock

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including CORTICUS.

Summary of the CORTICUS Trial (Sprung 2008)

Hydrocortisone therapy did not improve outcomes among patients with septic shock (onset within 72 hours), although it did shorten the duration of vasopressor dependence.

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