Ethinyl Estradiol; Levonorgestrel

Drug Usage Statistics, United States, 2014 - 2023

Ethinyl Estradiol; Levonorgestrel Summary for 2023

Top drug rank	#138 ( 10)
Estimated number of prescriptions in the United States (2023)	4,052,882
Estimated number of patients in the United States (2023)	1,217,443

Average total drug cost (USD)
Per prescription	$42.14
Per day of therapy	$0.55/day
Average out-of-pocket cost (USD)
Per prescription	$0.37
Per day of therapy	$≤0.01/day

Total Prescriptions and Patients Per Year (2014 - 2023)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2014	160	34
2015	95	65
2016	116	21
2017	139	23
2018	138	1

Year	Rank	Change
2019	124	14
2020	159	35
2021	144	15
2022	128	16
2023	138	10

Drug Cost Over Time (2014 - 2023)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2023)

Dosage Form	Strength	% of Dispensed Products
Tablet/capsule	90-20 mcg	100.0%

Distribution of Days Supplied (2023)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2023)
Estradiol	11,289,113
Ethinyl Estradiol; Norethindrone	8,611,957
Norethindrone	4,162,876
Ethinyl Estradiol; Levonorgestrel (this drug)	4,052,883
Ethinyl Estradiol; Etonogestrel	2,987,624
Medroxyprogesterone	1,095,997
Ethinyl Estradiol; Norelgestromin	658,000

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Afirmelle
Alesse
Altavera
Ashlyna
Aviane-21
Aviane-28
Ayuna
Balcoltra
Cerinta
Daysee
Dolishale
Elifemme
Enpresse-21
Enpresse-28
Falmina
Fayosim
Iclevia
Introvale
Jaimiess
Kurvelo
Lessina-21
Lessina-28
Levlite
Levonest
Levonorgestrel And Ethinyl Estradiol
Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate
Levora 0.15/30-21
Levora 0.15/30-28
LO Simpesse
Loseasonique
Lybrel
Marlissa
Minzoya
Myzilra
Nordette-21
Nordette-28
Orsythia
Portia-21
Portia-28
Preven Emergency Contraceptive Kit
Quartette
Quasense
Seasonale
Seasonique
Setlakin
Simpesse
Sylevia
Triphasil-21
Triphasil-28
Trivora-21
Trivora-28
Twirla
Tyblume
Vienva

Generic Drug Synonyms and Salts

Ethinyl Estradiol; Levonorgestrel
Levonorgestrel; Ethinyl Estradiol

FDA Approval Information

Established Pharmacologic Class (EPC):	Progestin, Progestin-containing Intrauterine Device, Estrogen
Initial FDA approval date:	5/10/1982
First FDA applicant:	Discn
First dosage form:	Tablet (oral-21)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Ethinyl Estradiol; Levonorgestrel

Drug Usage Statistics, United States, 2014 - 2023

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