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The Top 300 of 2023

Provided by the ClinCalc DrugStats Database

ClinCalc.com » Pharmacy » ClinCalc DrugStats » Top 300 Drugs

The Top 300 Drugs of 2023

Rank Drug Name Total Prescriptions (2023) Total Patients (2023) Annual Change
1 Atorvastatin 115,271,514 29,359,439 0
2 Metformin 85,685,925 20,439,610 0
3 Levothyroxine 80,930,390 18,222,687  1
4 Lisinopril 76,055,039 18,501,311  1
5 Amlodipine 68,743,650 17,890,210 0
6 Metoprolol 59,547,256 14,849,955 0
7 Albuterol 59,546,183 19,491,794 0
8 Losartan 56,174,734 14,084,276 0
9 Gabapentin 45,964,505 11,372,821  1
10 Omeprazole 45,290,895 12,767,473  1
11 Sertraline 42,578,018 9,388,487 0
12 Rosuvastatin 42,103,429 11,790,764  1
13 Pantoprazole 37,101,751 9,335,363  3
14 Escitalopram 37,088,584 8,758,483  1
15 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 32,566,892 4,718,419  1
16 Hydrochlorothiazide 31,775,977 8,891,444  4
17 Bupropion 30,349,390 6,316,963  4
18 Fluoxetine 27,518,944 5,723,737  4
19 Semaglutide 25,954,066 5,453,051  29
20 Montelukast 25,893,501 6,495,486  3
21 Trazodone 24,708,571 5,601,459  3
22 Simvastatin 24,585,762 6,448,427  3
23 Amoxicillin 23,510,711 18,545,966  3
24 Tamsulosin 22,898,080 6,660,839  4
25 Acetaminophen; Hydrocodone 21,506,768 7,545,384  2
26 Fluticasone 21,041,607 8,198,679  1
27 Meloxicam 20,703,689 6,804,169  2
28 Apixaban 19,829,711 4,903,848  1
29 Furosemide 19,138,347 5,488,921  5
30 Insulin Glargine 18,424,802 4,007,889  2
31 Duloxetine 18,067,156 4,261,516 0
32 Ibuprofen 17,525,800 9,910,191  1
33 Famotidine 16,883,437 5,210,639  16
34 Empagliflozin 16,744,581 3,796,361  22
35 Carvedilol 16,566,781 4,288,833  1
36 Tramadol 16,010,294 4,995,781  19
37 Alprazolam 15,881,366 3,296,320  4
38 Prednisone 15,794,243 9,128,022  8
39 Hydroxyzine 15,272,377 4,112,936  7
40 Buspirone 15,229,212 3,587,235  14
41 Clopidogrel 15,227,565 4,090,131  6
42 Glipizide 15,173,475 3,896,020 0
43 Citalopram 14,769,554 3,176,952  3
44 Potassium Chloride 14,514,606 4,177,294  9
45 Allopurinol 14,311,839 3,349,088  6
46 Aspirin 14,095,181 5,257,546  10
47 Cyclobenzaprine 13,973,843 5,283,574  2
48 Ergocalciferol 13,705,855 4,459,410  10
49 Oxycodone 13,502,066 5,654,494  11
50 Methylphenidate 13,248,734 2,350,510  18
51 Venlafaxine 13,234,839 2,973,726  7
52 Spironolactone 12,777,045 3,515,708 0
53 Ondansetron 12,503,157 6,097,220  8
54 Zolpidem 11,424,127 2,405,571  12
55 Cetirizine 11,399,497 3,931,282  12
56 Estradiol 11,289,112 3,347,560  6
57 Pravastatin 11,060,711 3,160,612  20
58 Hydrochlorothiazide; Lisinopril 10,986,814 2,395,399  5
59 Lamotrigine 10,895,178 2,048,990  1
60 Quetiapine 10,655,017 1,940,616  22
61 Fluticasone; Salmeterol 10,648,080 2,739,984  2
62 Clonazepam 10,614,830 2,195,742  5
63 Dulaglutide 10,358,270 2,228,365  11
64 Azithromycin 10,337,595 8,348,688  14
65 Hydrochlorothiazide; Losartan 9,882,017 2,369,334  10
66 Amoxicillin; Clavulanate 9,831,525 7,511,826  30
67 Latanoprost 9,792,338 2,715,551 0
68 Cholecalciferol 9,737,465 3,328,507  6
69 Propranolol 9,699,272 2,436,578  8
70 Ezetimibe 9,686,244 2,860,227  9
71 Topiramate 9,619,219 2,029,275  13
72 Paroxetine 9,577,610 1,753,057  20
73 Diclofenac 9,438,696 3,411,516  22
74 Budesonide; Formoterol 9,346,242 2,269,426  9
75 Atenolol 9,235,305 2,669,869  12
76 Lisdexamfetamine 9,134,058 1,477,908  7
77 Doxycycline 8,823,028 5,847,755  9
78 Pregabalin 8,644,140 1,726,535  13
79 Ethinyl Estradiol; Norethindrone 8,611,956 2,206,708  1
80 Glimepiride 8,459,350 2,078,077  16
81 Tizanidine 8,292,865 2,502,146  13
82 Clonidine 8,128,031 1,740,033  11
83 Fenofibrate 8,093,230 1,938,765  5
84 Insulin Lispro 8,053,451 1,834,930  14
85 Valsartan 7,983,441 2,158,502  32
86 Cephalexin 7,869,737 5,838,328  15
87 Baclofen 7,753,150 1,590,627  17
88 Rivaroxaban 7,743,941 1,936,505  2
89 Ferrous Sulfate 7,699,088 2,668,685  18
90 Amitriptyline 7,568,933 1,658,411  3
91 Finasteride 7,546,064 2,365,922  18
92 Dapagliflozin 7,444,831 1,793,760  23
93 Acetaminophen; Oxycodone 7,283,471 2,355,340  5
94 Folic Acid 7,276,938 2,168,940  29
95 Aripiprazole 7,197,548 1,608,575  11
96 Olmesartan 7,175,746 1,957,158  1
97 Ethinyl Estradiol; Norgestimate 7,175,433 1,866,523  2
98 Valacyclovir 7,121,821 2,794,911  15
99 Mirtazapine 6,977,141 1,616,829  6
100 Lorazepam 6,963,899 2,048,781  19
101 Levetiracetam 6,904,402 1,111,637  22
102 Insulin Aspart 6,835,070 1,683,030  26
103 Naproxen 6,808,486 3,219,878  14
104 Cyanocobalamin 6,727,915 2,081,388  27
105 Loratadine 6,699,690 2,271,288  33
106 Diltiazem 6,562,727 1,869,478  6
107 Sumatriptan 6,484,249 2,083,076  12
108 Triamcinolone 6,476,980 4,343,165  6
109 Hydralazine 6,327,003 1,863,936  12
110 Tirzepatide 6,310,173 1,324,240 0
111 Celecoxib 6,190,143 2,201,329  18
112 Acetaminophen 5,984,654 3,351,953  2
113 Alendronate 5,876,378 1,928,468  10
114 Oxybutynin 5,874,390 1,572,156  4
115 Hydrochlorothiazide; Triamterene 5,806,865 1,619,114  1
116 Warfarin 5,793,664 1,369,433  31
117 Progesterone 5,570,117 1,431,497  8
118 Fluticasone; Umeclidinium; Vilanterol 5,533,174 1,137,243  26
119 Testosterone 5,337,521 1,320,614  1
120 Nifedipine 5,318,746 1,327,349  31
121 Methocarbamol 5,288,774 2,566,436  5
122 Benzonatate 5,225,510 3,848,465  8
123 Sitagliptin 5,171,309 1,377,092  37
124 Chlorthalidone 5,041,667 1,459,485  16
125 Isosorbide 5,038,468 1,347,588  6
126 Donepezil 4,919,269 1,249,510  20
127 Dexmethylphenidate 4,826,840 944,279  18
128 Sulfamethoxazole; Trimethoprim 4,667,341 3,025,952  15
129 Clobetasol 4,643,351 2,351,795  27
130 Methotrexate 4,611,809 1,103,153  2
131 Hydroxychloroquine 4,438,796 1,199,079  19
132 Lovastatin 4,392,660 1,167,788  21
133 Pioglitazone 4,381,830 1,045,289  13
134 Irbesartan 4,225,718 1,003,836  66
135 Methylprednisolone 4,190,064 3,315,587  18
136 Norethindrone 4,162,876 1,470,696  1
137 Meclizine 4,086,408 1,598,165  8
138 Ethinyl Estradiol; Levonorgestrel 4,052,882 1,217,443  10
139 Fluticasone; Vilanterol 4,032,315 731,680  6
140 Ketoconazole 3,987,777 1,837,309  35
141 Thyroid 3,945,403 793,936  4
142 Azelastine 3,932,233 1,790,839  18
143 Nitrofurantoin 3,917,548 2,471,873  15
144 Adalimumab 3,900,241 591,018  97
145 Memantine 3,853,517 1,033,550  5
146 Prednisolone 3,839,256 2,456,200  10
147 Esomeprazole 3,828,168 1,097,633  25
148 Docusate 3,798,215 1,680,843 0
149 Clindamycin 3,775,741 2,471,485  2
150 Acyclovir 3,766,454 1,117,946  16
151 Sildenafil 3,760,682 1,215,572  6
152 Insulin Degludec 3,663,825 907,113  14
153 Insulin Detemir 3,584,061 817,923  26
154 Drospirenone; Ethinyl Estradiol 3,566,507 880,241  12
155 Ciprofloxacin 3,513,623 2,777,272  26
156 Morphine 3,500,073 647,436  16
157 Insulin Human; Insulin Isophane Human 3,487,065 540,782  35
158 Levocetirizine 3,461,897 982,120  6
159 Nirmatrelvir; Ritonavir 3,453,516 3,261,698  5
160 Valproate 3,442,917 625,116  14
161 Atomoxetine 3,431,315 755,464  52
162 Budesonide 3,366,337 890,477  15
163 Tiotropium 3,305,177 731,805  9
164 Melatonin 3,256,782 728,331  53
165 Cefdinir 3,168,051 2,519,650  3
166 Doxepin 3,122,267 604,157  52
167 Olanzapine 3,091,702 591,423  4
168 Phentermine 3,003,107 1,074,539  19
169 Ofloxacin 2,987,657 2,127,082  37
170 Ethinyl Estradiol; Etonogestrel 2,987,624 690,197  24
171 Mupirocin 2,982,603 2,180,313  9
172 Benazepril 2,965,135 712,858  13
173 Timolol 2,946,884 823,663  18
174 Magnesium Salts 2,903,672 821,090  33
175 Fluconazole 2,871,500 2,079,348  15
176 Risperidone 2,865,210 586,343  7
177 Verapamil 2,819,767 632,561  11
178 Linaclotide 2,817,174 720,731  11
179 Cyclosporine 2,796,137 1,250,521  6
180 Doxazosin 2,735,065 765,542 0
181 Albuterol; Ipratropium 2,727,765 788,302  3
182 Hydrocortisone 2,711,652 1,381,068  20
183 Diazepam 2,711,267 902,266  14
184 Telmisartan 2,693,425 661,282  44
185 Carbamazepine 2,687,079 512,106 0
186 Amlodipine; Benazepril 2,681,344 770,245  16
187 Lithium 2,680,151 464,216  25
188 Evolocumab 2,633,257 457,388 0
189 Desvenlafaxine 2,585,138 491,566  19
190 Dorzolamide 2,569,413 609,942  11
191 Nebivolol 2,568,389 844,304  18
192 Dicyclomine 2,561,309 1,016,843  16
193 Torsemide 2,545,175 700,275  9
194 Anastrozole 2,536,493 670,491  15
195 Enalapril 2,507,125 594,999  54
196 Polyethylene Glycol 3350 2,491,296 1,215,999  13
197 Tretinoin 2,454,022 1,349,696  41
198 Tadalafil 2,443,768 911,096  26
199 Sacubitril; Valsartan 2,442,361 657,646  34
200 Calcium 2,427,416 763,301 0
201 Pramipexole 2,398,374 551,096  8
202 Mesalamine 2,365,207 600,187 0
203 Metronidazole 2,318,178 1,737,004  70
204 Nortriptyline 2,314,282 574,267  13
205 Emtricitabine; Tenofovir 2,273,387 413,965 0
206 Rimegepant 2,263,880 455,115 0
207 Nitroglycerin 2,238,376 1,017,732  11
208 Rizatriptan 2,219,594 862,728  18
209 Liraglutide 2,191,691 671,031  70
210 Acetaminophen; Codeine 2,189,480 1,131,229  44
211 Ramipril 2,148,133 576,128  24
212 Ropinirole 2,086,907 707,906  49
213 Brimonidine 2,061,060 479,974  14
214 Mirabegron 2,045,781 660,130  8
215 Colchicine 2,010,102 798,172  18
216 Ticagrelor 2,006,287 541,032  13
217 Terazosin 1,989,756 573,398 0
218 Amiodarone 1,974,861 678,884  19
219 Fexofenadine 1,951,572 542,033  38
220 Liothyronine 1,884,613 568,396  16
221 Bisoprolol 1,816,701 562,441  28
222 Omega-3-acid Ethyl Esters 1,810,280 602,843  2
223 Flecainide 1,805,937 501,667 0
224 Oxcarbazepine 1,763,679 391,344  57
225 Desogestrel; Ethinyl Estradiol 1,722,386 581,721  64
226 Ascorbic Acid 1,705,386 623,102 0
227 Sodium Salts 1,698,017 591,392  11
228 Ketorolac 1,627,126 1,045,788  5
229 Dorzolamide; Timolol 1,620,620 460,097  4
230 Promethazine 1,611,034 805,538  32
231 Levofloxacin 1,583,754 1,094,753  20
232 Labetalol 1,555,592 539,610  17
233 Nystatin 1,528,640 856,580  3
234 Cyproheptadine 1,522,003 292,977  59
235 Erythromycin 1,513,465 1,086,795  36
236 Dutasteride 1,505,889 471,334 0
237 Moxifloxacin 1,504,242 1,012,790  36
238 Bimatoprost 1,491,206 433,473  43
239 Primidone 1,488,529 433,038 0
240 Sucralfate 1,487,376 527,574  26
241 Betamethasone; Clotrimazole 1,470,861 649,237  1
242 Senna; Docusate 1,440,174 571,667  19
243 Bumetanide 1,419,204 389,856 0
244 Icosapent Ethyl 1,378,688 399,887  15
245 Solifenacin 1,292,098 435,495  35
246 Dexamethasone 1,251,533 660,725  12
247 Epinephrine 1,248,425 722,247  7
248 Penicillin V 1,240,696 1,042,246  11
249 Calcitriol 1,217,012 320,997  5
250 Oseltamivir 1,207,283 1,018,277  45
251 Polymyxin B; Trimethoprim 1,200,830 1,105,738  1
252 Dextromethorphan; Promethazine 1,195,581 958,832  8
253 Terbinafine 1,181,009 722,494  2
254 Linagliptin 1,158,876 440,093 0
255 Methimazole 1,128,558 350,343 0
256 Metoclopramide 1,116,507 495,884  11
257 Medroxyprogesterone 1,095,997 417,258  19
258 Pancrelipase Amylase; Pancrelipase Lipase; Pancrelipase Protease 1,076,565 269,108  5
259 Clotrimazole 1,058,881 569,947 0
260 Dexamethasone; Neomycin; Polymyxin B 1,049,128 832,122  14
261 Calcium Phosphate; Cholecalciferol 1,043,667 418,270  15
262 Acetaminophen; Butalbital; Caffeine 1,039,901 655,619  14
263 Guanfacine 1,039,054 176,625  12
264 Sodium Fluoride 1,037,661 559,898  43
265 Codeine; Guaifenesin 972,224 834,325  7
266 Lactulose 966,210 388,255  1
267 Fluorouracil 964,215 793,472  3
268 Ipratropium 944,080 538,618  49
269 Olopatadine 930,171 377,675  19
270 Chlorhexidine 912,485 777,371  40
271 Nabumetone 869,463 270,062  32
272 Mometasone 865,193 545,150  39
273 Polyethylene Glycol 3350 With Electrolytes 842,997 785,849  9
274 Hydroquinone 835,288 449,868  6
275 Phenazopyridine 827,433 633,150 0
276 Loperamide 822,307 351,347  21
277 Lidocaine 810,186 482,428  15
278 Ciclopirox 787,556 502,983  31
279 Cefuroxime 783,926 626,445  4
280 Betamethasone 760,520 569,106  17
281 Brompheniramine; Dextromethorphan; Pseudoephedrine 748,649 578,476  16
282 Ethinyl Estradiol; Norgestrel 726,740 176,164  18
283 Ciprofloxacin; Dexamethasone 723,485 664,539  3
284 Diphenhydramine 707,624 278,928  26
285 Ethinyl Estradiol; Norelgestromin 658,000 219,111  18
286 Atropine; Diphenoxylate 614,352 222,391  2
287 Indomethacin 593,608 310,001  31
288 Niacin 534,979 138,204  29
289 Lactate 533,902 210,534  2
290 Vitamin E 519,661 265,241  46
291 Guaifenesin 511,688 252,124  4
292 Pseudoephedrine 497,307 260,899  14
293 Bisacodyl 481,188 210,150  22
294 Riboflavin 451,739 87,204  8
295 Ivermectin 450,417 117,070  19
296 Etodolac 450,221 232,690  17
297 Lactobacillus Acidophilus 445,216 193,744  77
298 Tobramycin 424,144 281,102  17
299 Ketotifen 409,520 185,557  56
300 Loratadine; Pseudoephedrine 408,298 118,353  11

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2024 calendar year), MEPS releasing the data from patients (August 2026), and the ClinCalc DrugStats release (a few months later, classified as the 2024 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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