Topical Agents

Multum Therapeutic Class Comparison, United States, 2021

Total Prescriptions in (2021)

Drug Name Total Prescriptions (2021) Percent Share
Fluticasone 25,283,015 18.1%
Estradiol 11,382,724 8.2%
Diclofenac 11,037,695 7.9%
Latanoprost 9,895,399 7.1%
Triamcinolone 6,413,003 4.6%
Clindamycin 5,194,038 3.7%
Azelastine 4,011,209 2.9%
Prednisolone 3,816,336 2.7%
Brimonidine 3,470,856 2.5%
Ketoconazole 3,429,167 2.5%
Clobetasol 3,428,139 2.5%
Timolol 3,406,226 2.4%
Cyclosporine 2,802,770 2%
Dorzolamide; Timolol 2,518,854 1.8%
Hydrocortisone 2,459,728 1.8%
Dorzolamide 2,277,156 1.6%
Mupirocin 2,274,043 1.6%
Bimatoprost 2,257,784 1.6%
Tretinoin 2,167,095 1.6%
Ketorolac 2,124,922 1.5%
Sodium Salts 1,782,362 1.3%
Nystatin 1,737,716 1.2%
Ofloxacin 1,596,737 1.1%
Chlorhexidine 1,513,289 1.1%
Fluocinonide 1,402,662 1%
Betamethasone 1,389,641 1%
Erythromycin 1,274,918 0.9%
Olopatadine 1,215,596 0.9%
Mometasone 1,163,500 0.8%
Lidocaine 1,115,403 0.8%
Ipratropium 1,074,166 0.8%
Ciclopirox 976,972 0.7%
Clotrimazole 959,022 0.7%
Betamethasone; Clotrimazole 958,479 0.7%
Fluorouracil 807,188 0.6%
Hydroquinone 802,769 0.6%
Benzoyl Peroxide 787,534 0.6%
Moxifloxacin 713,971 0.5%
Imiquimod 622,393 0.4%
Oxymetazoline 608,917 0.4%
Tacrolimus 549,984 0.4%
Tobramycin 501,041 0.4%
Bacitracin 498,303 0.4%
Ketotifen 467,257 0.3%
Neomycin; Polymyxin B; Hydrocortisone 449,389 0.3%
Silver Sulfadiazine 400,986 0.3%
Lactate 381,676 0.3%
Adapalene; Benzoyl Peroxide 342,293 0.2%
Azelate 323,469 0.2%
Azelastine; Fluticasone 274,995 0.2%
Dapsone 272,530 0.2%
Sulfacetamide; Sulfur 225,487 0.2%
Cromolyn 200,137 0.1%
Pyrithione 199,366 0.1%
Benzoyl Peroxide; Clindamycin 188,399 0.1%
Lanolin 186,135 0.1%
Collagenase 164,892 0.1%
Urea 151,401 0.1%
Sulfacetamide 143,026 0.1%
Adapalene 136,073 0.1%
Permethrin 133,114 0.1%
Ivermectin 130,654 0.1%
Salicylic Acid 117,764 0.1%
Bacitracin; Polymyxin B 111,164 0.1%
Tazarotene 104,674 0.1%
Gentamicin 93,167 0.1%
Menthol; Methyl Salicylate 93,068 0.1%
Podofilox 75,470 0.1%
Menthol; Camphor 52,644 0%
Bacitracin; Neomycin; Polymyxin B; Pramoxine 46,491 0%
Dimethicone 44,838 0%
Propylene Glycol Dipropionate 29,788 0%
Epinastine 29,212 0%
Bacitracin; Neomycin; Polymyxin B 26,831 0%
Hypochlorite 26,082 0%
Trifarotene 25,223 0%
Witch Hazel 20,991 0%
Phenylephrine 18,861 0%
Cadexomer Iodine 14,054 0%
Isopropyl Alcohol 13,440 0%
Petrolatum 13,125 0%
Flunisolide 7,344 0%
Bepotastine 5,747 0%
Gentian Violet 3,213 0%
Diphenhydramine; Zinc 0 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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