Topical Agents

Multum Therapeutic Class Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Fluticasone	21,041,608	15.4%
Estradiol	11,289,113	8.3%
Latanoprost	9,792,339	7.2%
Diclofenac	9,438,697	6.9%
Triamcinolone	6,476,980	4.7%
Clobetasol	4,643,352	3.4%
Ketoconazole	3,987,778	2.9%
Azelastine	3,932,233	2.9%
Prednisolone	3,839,257	2.8%
Clindamycin	3,775,741	2.8%
Ciprofloxacin	3,513,624	2.6%
Ofloxacin	2,987,658	2.2%
Mupirocin	2,982,604	2.2%
Timolol	2,946,884	2.2%
Cyclosporine	2,796,138	2.1%
Hydrocortisone	2,711,653	2%
Dorzolamide	2,569,414	1.9%
Tretinoin	2,454,022	1.8%
Metronidazole	2,318,179	1.7%
Brimonidine	2,061,061	1.5%
Sodium Salts	1,698,018	1.2%
Ketorolac	1,627,126	1.2%
Dorzolamide; Timolol	1,620,621	1.2%
Nystatin	1,528,640	1.1%
Erythromycin	1,513,466	1.1%
Moxifloxacin	1,504,242	1.1%
Bimatoprost	1,491,206	1.1%
Betamethasone; Clotrimazole	1,470,861	1.1%
Polymyxin B; Trimethoprim	1,200,830	0.9%
Clotrimazole	1,058,881	0.8%
Dexamethasone; Neomycin; Polymyxin B	1,049,128	0.8%
Sodium Fluoride	1,037,662	0.8%
Fluorouracil	964,215	0.7%
Ipratropium	944,081	0.7%
Olopatadine	930,171	0.7%
Chlorhexidine	912,485	0.7%
Mometasone	865,193	0.6%
Hydroquinone	835,288	0.6%
Lidocaine	810,187	0.6%
Ciclopirox	787,556	0.6%
Betamethasone	760,521	0.6%
Ciprofloxacin; Dexamethasone	723,486	0.5%
Lactate	533,902	0.4%
Ivermectin	450,417	0.3%
Tobramycin	424,145	0.3%
Ketotifen	409,520	0.3%
Benzoyl Peroxide; Clindamycin	371,710	0.3%
Benzoyl Peroxide	351,676	0.3%
Azelate	262,201	0.2%
Sulfacetamide; Sulfur	255,958	0.2%
Salicylic Acid	218,564	0.2%
Adapalene; Benzoyl Peroxide	200,531	0.1%
Dapsone	172,917	0.1%
Mometasone; Olopatadine	169,856	0.1%
Bacitracin	166,518	0.1%
Azelastine; Fluticasone	165,218	0.1%
Menthol; Methyl Salicylate	160,957	0.1%
Oxymetazoline	156,902	0.1%
Permethrin	122,356	0.1%
Gentamicin	117,663	0.1%
Cromolyn	98,602	0.1%
Pyrithione	90,006	0.1%
Adapalene	78,171	0.1%
Clascoterone	74,465	0.1%
Petrolatum	67,798	0%
Urea	64,472	0%
Beclomethasone	51,207	0%
Stannous Fluoride	48,069	0%
Diphenhydramine; Zinc	45,761	0%
Tretinoin; Niacinamide	32,935	0%
Bepotastine	25,386	0%
Povidone Iodine	24,314	0%
Witch Hazel	20,563	0%
Bacitracin; Neomycin; Polymyxin B	16,768	0%
Trifarotene	14,319	0%
Isopropyl Alcohol	13,499	0%
Potassium Nitrate; Sodium Fluoride	8,470	0%
Benzoyl Peroxide; Erythromycin	0	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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