Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2021

Total Prescriptions in (2021)

Drug Name Total Prescriptions (2021) Percent Share
Gabapentin 47,125,974 9.8%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 30,371,089 6.3%
Acetaminophen; Hydrocodone 26,599,439 5.6%
Meloxicam 18,226,904 3.8%
Aspirin 17,686,612 3.7%
Ibuprofen 17,043,551 3.6%
Tramadol 15,446,495 3.2%
Alprazolam 15,380,321 3.2%
Methylphenidate 15,282,089 3.2%
Cyclobenzaprine 14,426,040 3%
Clonazepam 14,197,548 3%
Lamotrigine 13,244,443 2.8%
Buspirone 12,694,069 2.6%
Hydroxyzine 11,643,509 2.4%
Oxycodone 11,552,449 2.4%
Diclofenac 11,037,695 2.3%
Zolpidem 10,838,845 2.3%
Topiramate 10,042,403 2.1%
Lisdexamfetamine 9,835,531 2.1%
Pregabalin 8,996,019 1.9%
Acetaminophen; Oxycodone 8,987,786 1.9%
Lorazepam 8,860,599 1.8%
Ondansetron 8,790,270 1.8%
Tizanidine 8,192,390 1.7%
Naproxen 7,592,556 1.6%
Celecoxib 7,082,350 1.5%
Levetiracetam 6,633,071 1.4%
Baclofen 6,516,375 1.4%
Sumatriptan 5,873,390 1.2%
Acetaminophen 5,327,156 1.1%
Dexmethylphenidate 4,936,399 1%
Methocarbamol 4,798,559 1%
Oxcarbazepine 4,492,393 0.9%
Donepezil 4,435,099 0.9%
Meclizine 4,269,436 0.9%
Ropinirole 4,102,325 0.9%
Diazepam 3,898,004 0.8%
Valproate 3,633,026 0.8%
Morphine 3,629,439 0.8%
Rizatriptan 3,505,154 0.7%
Memantine 3,238,257 0.7%
Acetaminophen; Codeine 2,794,323 0.6%
Promethazine 2,595,247 0.5%
Phentermine 2,142,309 0.4%
Temazepam 2,139,735 0.4%
Pramipexole 2,126,161 0.4%
Ketorolac 2,124,922 0.4%
Atomoxetine 1,948,141 0.4%
Acetaminophen; Butalbital; Caffeine 1,757,902 0.4%
Diphenhydramine 1,573,897 0.3%
Nabumetone 1,401,463 0.3%
Carbidopa; Levodopa 1,375,526 0.3%
Indomethacin 1,374,643 0.3%
Naltrexone 1,343,281 0.3%
Melatonin 1,289,851 0.3%
Hydromorphone 1,243,299 0.3%
Etodolac 456,118 0.1%
Sulindac 337,904 0.1%
Hydrocodone 286,675 0.1%
Diclofenac; Misoprostol 126,293 0%
Famotidine; Ibuprofen 111,801 0%
Flurbiprofen 78,952 0%
Piroxicam 20,466 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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