Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2020

Total Prescriptions in (2020)

Drug Name	Total Prescriptions (2020)	Percent Share
Gabapentin	49,961,067	9.6%
Acetaminophen; Hydrocodone	30,100,356	5.8%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	26,080,152	5%
Meloxicam	19,808,582	3.8%
Tramadol	17,475,420	3.4%
Aspirin	17,287,373	3.3%
Alprazolam	16,780,806	3.2%
Ibuprofen	16,533,209	3.2%
Cyclobenzaprine	16,151,696	3.1%
Methylphenidate	15,449,350	3%
Clonazepam	14,758,212	2.8%
Zolpidem	14,272,253	2.7%
Oxycodone	12,289,519	2.4%
Buspirone	11,820,023	2.3%
Topiramate	11,482,269	2.2%
Lamotrigine	10,801,629	2.1%
Lorazepam	10,559,374	2%
Acetaminophen; Oxycodone	10,086,467	1.9%
Hydroxyzine	10,058,837	1.9%
Diclofenac	9,926,750	1.9%
Pregabalin	9,227,867	1.8%
Ondansetron	8,773,585	1.7%
Tizanidine	8,705,644	1.7%
Lisdexamfetamine	8,647,784	1.7%
Naproxen	8,184,639	1.6%
Levetiracetam	7,967,536	1.5%
Celecoxib	7,089,212	1.4%
Baclofen	6,009,146	1.2%
Valproate	6,000,123	1.2%
Sumatriptan	5,915,272	1.1%
Donepezil	5,899,553	1.1%
Acetaminophen	5,610,164	1.1%
Methocarbamol	4,981,836	1%
Diazepam	4,972,397	1%
Dexmethylphenidate	4,802,552	0.9%
Rizatriptan	4,667,144	0.9%
Morphine	4,384,337	0.8%
Meclizine	4,349,445	0.8%
Oxcarbazepine	4,276,700	0.8%
Memantine	3,928,016	0.8%
Ropinirole	3,776,826	0.7%
Phentermine	3,071,042	0.6%
Carbamazepine	2,858,881	0.6%
Buprenorphine	2,850,299	0.5%
Acetaminophen; Codeine	2,791,618	0.5%
Diphenhydramine	2,614,774	0.5%
Pramipexole	2,589,439	0.5%
Acetaminophen; Butalbital; Caffeine	2,396,593	0.5%
Promethazine	2,309,125	0.4%
Temazepam	2,143,561	0.4%
Benztropine	2,060,460	0.4%
Eszopiclone	1,937,205	0.4%
Erenumab	1,929,984	0.4%
Ketorolac	1,750,298	0.3%
Hydromorphone	1,747,152	0.3%
Doxepin	1,721,844	0.3%
Phenytoin	1,616,629	0.3%
Primidone	1,404,365	0.3%
Zonisamide	1,316,716	0.3%
Atomoxetine	1,225,656	0.2%
Melatonin	1,090,897	0.2%
Naltrexone	1,070,563	0.2%
Modafinil	1,056,221	0.2%
Nabumetone	906,743	0.2%
Indomethacin	882,500	0.2%
Metoclopramide	642,109	0.1%
Prochlorperazine	609,966	0.1%
Carbidopa; Levodopa	527,530	0.1%
Metaxalone	420,704	0.1%
Sulindac	365,698	0.1%
Codeine	325,313	0.1%
Esomeprazole; Naproxen	306,557	0.1%
Etodolac	300,667	0.1%
Piroxicam	268,675	0.1%
Flurbiprofen	230,134	0%
Amphetamine	163,177	0%
Ketoprofen	15,950	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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