Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2020

Total Prescriptions in (2020)

Drug Name Total Prescriptions (2020) Percent Share
Gabapentin 49,961,067 9.6%
Acetaminophen; Hydrocodone 30,100,356 5.8%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 26,080,152 5%
Meloxicam 19,808,582 3.8%
Tramadol 17,475,420 3.4%
Aspirin 17,287,373 3.3%
Alprazolam 16,780,806 3.2%
Ibuprofen 16,533,209 3.2%
Cyclobenzaprine 16,151,696 3.1%
Methylphenidate 15,449,350 3%
Clonazepam 14,758,212 2.8%
Zolpidem 14,272,253 2.7%
Oxycodone 12,289,519 2.4%
Buspirone 11,820,023 2.3%
Topiramate 11,482,269 2.2%
Lamotrigine 10,801,629 2.1%
Lorazepam 10,559,374 2%
Acetaminophen; Oxycodone 10,086,467 1.9%
Hydroxyzine 10,058,837 1.9%
Diclofenac 9,926,750 1.9%
Pregabalin 9,227,867 1.8%
Ondansetron 8,773,585 1.7%
Tizanidine 8,705,644 1.7%
Lisdexamfetamine 8,647,784 1.7%
Naproxen 8,184,639 1.6%
Levetiracetam 7,967,536 1.5%
Celecoxib 7,089,212 1.4%
Baclofen 6,009,146 1.2%
Valproate 6,000,123 1.2%
Sumatriptan 5,915,272 1.1%
Donepezil 5,899,553 1.1%
Acetaminophen 5,610,164 1.1%
Methocarbamol 4,981,836 1%
Diazepam 4,972,397 1%
Dexmethylphenidate 4,802,552 0.9%
Rizatriptan 4,667,144 0.9%
Morphine 4,384,337 0.8%
Meclizine 4,349,445 0.8%
Oxcarbazepine 4,276,700 0.8%
Memantine 3,928,016 0.8%
Ropinirole 3,776,826 0.7%
Phentermine 3,071,042 0.6%
Carbamazepine 2,858,881 0.6%
Buprenorphine 2,850,299 0.5%
Acetaminophen; Codeine 2,791,618 0.5%
Diphenhydramine 2,614,774 0.5%
Pramipexole 2,589,439 0.5%
Acetaminophen; Butalbital; Caffeine 2,396,593 0.5%
Promethazine 2,309,125 0.4%
Temazepam 2,143,561 0.4%
Benztropine 2,060,460 0.4%
Eszopiclone 1,937,205 0.4%
Erenumab 1,929,984 0.4%
Ketorolac 1,750,298 0.3%
Hydromorphone 1,747,152 0.3%
Doxepin 1,721,844 0.3%
Phenytoin 1,616,629 0.3%
Primidone 1,404,365 0.3%
Zonisamide 1,316,716 0.3%
Atomoxetine 1,225,656 0.2%
Melatonin 1,090,897 0.2%
Naltrexone 1,070,563 0.2%
Modafinil 1,056,221 0.2%
Nabumetone 906,743 0.2%
Indomethacin 882,500 0.2%
Metoclopramide 642,109 0.1%
Prochlorperazine 609,966 0.1%
Carbidopa; Levodopa 527,530 0.1%
Metaxalone 420,704 0.1%
Sulindac 365,698 0.1%
Codeine 325,313 0.1%
Esomeprazole; Naproxen 306,557 0.1%
Etodolac 300,667 0.1%
Piroxicam 268,675 0.1%
Flurbiprofen 230,134 0%
Amphetamine 163,177 0%
Ketoprofen 15,950 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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