Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Gabapentin	45,964,506	9.7%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	32,566,892	6.9%
Acetaminophen; Hydrocodone	21,506,769	4.6%
Meloxicam	20,703,690	4.4%
Ibuprofen	17,525,800	3.7%
Tramadol	16,010,294	3.4%
Alprazolam	15,881,367	3.4%
Hydroxyzine	15,272,377	3.2%
Buspirone	15,229,213	3.2%
Aspirin	14,095,182	3%
Cyclobenzaprine	13,973,844	3%
Oxycodone	13,502,067	2.9%
Methylphenidate	13,248,735	2.8%
Ondansetron	12,503,158	2.6%
Zolpidem	11,424,127	2.4%
Lamotrigine	10,895,179	2.3%
Clonazepam	10,614,830	2.2%
Topiramate	9,619,220	2%
Diclofenac	9,438,697	2%
Lisdexamfetamine	9,134,059	1.9%
Pregabalin	8,644,141	1.8%
Tizanidine	8,292,865	1.8%
Baclofen	7,753,151	1.6%
Acetaminophen; Oxycodone	7,283,472	1.5%
Lorazepam	6,963,900	1.5%
Levetiracetam	6,904,402	1.5%
Naproxen	6,808,487	1.4%
Sumatriptan	6,484,250	1.4%
Celecoxib	6,190,144	1.3%
Acetaminophen	5,984,655	1.3%
Methocarbamol	5,288,774	1.1%
Donepezil	4,919,270	1%
Dexmethylphenidate	4,826,841	1%
Meclizine	4,086,409	0.9%
Memantine	3,853,518	0.8%
Morphine	3,500,074	0.7%
Valproate	3,442,918	0.7%
Atomoxetine	3,431,316	0.7%
Melatonin	3,256,782	0.7%
Doxepin	3,122,268	0.7%
Phentermine	3,003,107	0.6%
Diazepam	2,711,268	0.6%
Carbamazepine	2,687,079	0.6%
Pramipexole	2,398,375	0.5%
Rimegepant	2,263,880	0.5%
Rizatriptan	2,219,595	0.5%
Acetaminophen; Codeine	2,189,480	0.5%
Ropinirole	2,086,907	0.4%
Oxcarbazepine	1,763,680	0.4%
Ketorolac	1,627,126	0.3%
Promethazine	1,611,034	0.3%
Primidone	1,488,529	0.3%
Metoclopramide	1,116,508	0.2%
Acetaminophen; Butalbital; Caffeine	1,039,901	0.2%
Nabumetone	869,464	0.2%
Diphenhydramine	707,624	0.1%
Indomethacin	593,609	0.1%
Etodolac	450,221	0.1%
Carbidopa; Levodopa	258,032	0.1%
Codeine	202,788	0%
Sulindac	168,142	0%
Dextroamphetamine	119,372	0%
Hydrocodone	79,852	0%
Oxaprozin	72,993	0%
Diclofenac; Misoprostol	47,412	0%
Aspirin; Citric Acid; Sodium Bicarbonate	10,494	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

Search

Mailing List

Get Email Updates

New and Popular

Open Menu

Cite This Page

Show AMA citation

RxHero - Complete quests, earn points ... Develop rock-solid drug therapy knowledge

Disclaimer - Privacy Policy - Contact Us
Updated Sep 12, 2021

Top