Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2022

Total Prescriptions in (2022)

Drug Name	Total Prescriptions (2022)	Percent Share
Gabapentin	40,141,487	8.7%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	34,690,298	7.6%
Acetaminophen; Hydrocodone	23,521,229	5.1%
Meloxicam	18,859,721	4.1%
Methylphenidate	17,705,265	3.9%
Ibuprofen	17,493,911	3.8%
Aspirin	16,981,811	3.7%
Alprazolam	14,988,527	3.3%
Cyclobenzaprine	13,724,245	3%
Hydroxyzine	13,652,752	3%
Diclofenac	12,480,263	2.7%
Buspirone	12,332,590	2.7%
Tramadol	12,203,198	2.7%
Clonazepam	11,711,066	2.6%
Lamotrigine	11,704,669	2.5%
Oxycodone	11,314,082	2.5%
Ondansetron	10,880,347	2.4%
Zolpidem	9,972,232	2.2%
Lisdexamfetamine	9,791,955	2.1%
Lorazepam	8,502,480	1.9%
Topiramate	8,210,654	1.8%
Naproxen	7,381,940	1.6%
Pregabalin	7,167,541	1.6%
Celecoxib	7,023,512	1.5%
Tizanidine	6,971,104	1.5%
Sumatriptan	6,899,199	1.5%
Acetaminophen; Oxycodone	6,531,256	1.4%
Baclofen	6,099,128	1.3%
Dexmethylphenidate	5,809,076	1.3%
Acetaminophen	5,512,121	1.2%
Levetiracetam	5,202,580	1.1%
Methocarbamol	5,109,104	1.1%
Meclizine	4,776,929	1%
Morphine	4,101,413	0.9%
Donepezil	3,855,536	0.8%
Phentermine	3,738,423	0.8%
Memantine	3,703,294	0.8%
Ropinirole	3,241,699	0.7%
Acetaminophen; Codeine	3,179,642	0.7%
Oxcarbazepine	3,138,992	0.7%
Diazepam	3,093,210	0.7%
Valproate	2,969,360	0.6%
Rizatriptan	2,297,919	0.5%
Pramipexole	2,224,945	0.5%
Promethazine	2,149,358	0.5%
Atomoxetine	1,822,925	0.4%
Melatonin	1,733,014	0.4%
Doxepin	1,729,966	0.4%
Ketorolac	1,681,242	0.4%
Hydromorphone	1,531,449	0.3%
Nabumetone	1,463,756	0.3%
Metoclopramide	1,344,932	0.3%
Acetaminophen; Butalbital; Caffeine	1,308,103	0.3%
Indomethacin	1,097,589	0.2%
Diphenhydramine	1,091,279	0.2%
Carbidopa; Levodopa	761,578	0.2%
Sulindac	260,923	0.1%
Etodolac	257,226	0.1%
Salsalate	26,049	0%
Diclofenac; Misoprostol	25,434	0%
Oxaprozin	11,605	0%
Piroxicam	4,972	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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