Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2019

Total Prescriptions in (2019)

Drug Name Total Prescriptions (2019) Percent Share
Gabapentin 47,149,506 8.7%
Acetaminophen; Hydrocodone 30,355,778 5.6%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 24,600,698 4.5%
Ibuprofen 21,746,703 4%
Meloxicam 21,459,849 4%
Tramadol 19,838,715 3.7%
Aspirin 18,143,138 3.3%
Alprazolam 17,533,262 3.2%
Cyclobenzaprine 15,597,385 2.9%
Clonazepam 15,578,495 2.9%
Zolpidem 15,419,648 2.8%
Oxycodone 14,669,103 2.7%
Methylphenidate 14,233,406 2.6%
Acetaminophen; Oxycodone 11,962,651 2.2%
Ondansetron 11,856,066 2.2%
Naproxen 11,762,234 2.2%
Topiramate 10,927,224 2%
Lorazepam 10,875,212 2%
Lamotrigine 10,690,318 2%
Diclofenac 10,115,975 1.9%
Hydroxyzine 9,898,264 1.8%
Buspirone 9,881,603 1.8%
Lisdexamfetamine 9,775,262 1.8%
Pregabalin 9,625,190 1.8%
Tizanidine 8,729,695 1.6%
Levetiracetam 7,560,851 1.4%
Sumatriptan 7,050,329 1.3%
Celecoxib 6,595,237 1.2%
Valproate 5,824,937 1.1%
Diazepam 5,711,207 1.1%
Donepezil 5,538,292 1%
Baclofen 5,366,102 1%
Dexmethylphenidate 5,179,401 1%
Methocarbamol 4,888,933 0.9%
Ropinirole 4,487,533 0.8%
Acetaminophen 4,483,857 0.8%
Meclizine 4,258,969 0.8%
Phentermine 3,842,226 0.7%
Oxcarbazepine 3,796,002 0.7%
Morphine 3,756,696 0.7%
Pramipexole 3,685,678 0.7%
Memantine 3,631,970 0.7%
Rizatriptan 3,514,595 0.6%
Acetaminophen; Codeine 3,508,582 0.6%
Promethazine 3,392,439 0.6%
Carbamazepine 2,864,887 0.5%
Melatonin 2,586,638 0.5%
Temazepam 2,324,388 0.4%
Benztropine 2,238,056 0.4%
Eszopiclone 2,166,393 0.4%
Butalbital; Acetaminophen; Caffeine 2,116,128 0.4%
Buprenorphine 2,072,034 0.4%
Doxepin 2,033,456 0.4%
Hydromorphone 2,013,470 0.4%
Ketorolac 1,602,924 0.3%
Indomethacin 1,574,457 0.3%
Atomoxetine 1,563,863 0.3%
Phenytoin 1,536,390 0.3%
Buprenorphine; Naloxone 1,514,317 0.3%
Naltrexone 1,465,584 0.3%
Fentanyl 1,440,012 0.3%
Diphenhydramine 1,433,911 0.3%
Zonisamide 1,432,119 0.3%
Erenumab 1,416,499 0.3%
Nabumetone 1,211,008 0.2%
Prochlorperazine 1,186,208 0.2%
Primidone 954,150 0.2%
Modafinil 926,626 0.2%
Metoclopramide 878,287 0.2%
Carisoprodol 872,202 0.2%
Etodolac 712,628 0.1%
Carbidopa; Levodopa 497,397 0.1%
Ibuprofen; Famotidine 416,323 0.1%
Piroxicam 405,479 0.1%
Sulindac 318,884 0.1%
Diflunisal 116,623 0%
Diclofenac; Misoprostol 34,517 0%
Flurbiprofen 21,338 0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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