Central Nervous System Agents

Multum Therapeutic Class Comparison, United States, 2018

Total Prescriptions in (2018)

Drug Name Total Prescriptions (2018) Percent Share
Gabapentin 45,586,654 7.2%
Acetaminophen; Hydrocodone Bitartrate 42,073,176 6.7%
Furosemide 29,857,946 4.7%
Acetaminophen 27,907,361 4.4%
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,776 4%
Tramadol Hydrochloride 24,952,328 4%
Ibuprofen 24,453,501 3.9%
Meloxicam 22,610,690 3.6%
Alprazolam 20,843,480 3.3%
Aspirin 19,750,180 3.1%
Cyclobenzaprine 18,041,836 2.9%
Methylphenidate 17,467,266 2.8%
Clonazepam 17,064,643 2.7%
Oxycodone 16,967,480 2.7%
Lorazepam 13,222,989 2.1%
Zolpidem Tartrate 12,877,941 2%
Ondansetron 12,240,226 1.9%
Naproxen 11,942,766 1.9%
Lamotrigine 11,582,775 1.8%
Pregabalin 11,429,655 1.8%
Diclofenac 11,372,070 1.8%
Hydroxyzine 10,431,207 1.7%
Lisdexamfetamine Dimesylate 10,011,146 1.6%
Tizanidine 8,901,700 1.4%
Topiramate 8,648,513 1.4%
Buspirone Hydrochloride 8,149,119 1.3%
Levetiracetam 7,666,166 1.2%
Sumatriptan 6,674,686 1.1%
Diazepam 6,448,085 1%
Ropinirole Hydrochloride 6,224,575 1%
Methocarbamol 5,849,168 0.9%
Baclofen 5,642,530 0.9%
Celecoxib 5,445,346 0.9%
Donepezil Hydrochloride 5,412,436 0.9%
Divalproex Sodium 5,275,298 0.8%
Morphine 5,225,089 0.8%
Meclizine Hydrochloride 4,960,256 0.8%
Promethazine Hydrochloride 4,171,552 0.7%
Dexmethylphenidate Hydrochloride 3,961,349 0.6%
Oxcarbazepine 3,915,509 0.6%
Atomoxetine Hydrochloride 3,848,913 0.6%
Phentermine 3,683,239 0.6%
Carbidopa; Levodopa 3,638,766 0.6%
Rizatriptan Benzoate 3,490,815 0.6%
Acetaminophen; Butalbital 3,242,636 0.5%
Temazepam 3,173,562 0.5%
Memantine Hydrochloride 3,129,751 0.5%
Ketorolac Tromethamine 3,085,293 0.5%
Pramipexole Dihydrochloride 2,984,634 0.5%
Magnesium 2,905,859 0.5%
Carbamazepine 2,840,744 0.4%
Hydromorphone Hydrochloride 2,378,610 0.4%
Indomethacin 2,160,197 0.3%
Metoclopramide Hydrochloride 2,087,259 0.3%
Buprenorphine 1,984,590 0.3%
Dextroamphetamine Sulfate 1,888,102 0.3%
Diphenhydramine Hydrochloride 1,805,035 0.3%
Benztropine Mesylate 1,717,960 0.3%
Eszopiclone 1,715,222 0.3%
Phenytoin 1,643,498 0.3%
Nabumetone 1,554,892 0.2%
Doxepin Hydrochloride 1,519,877 0.2%
Primidone 1,437,305 0.2%
Modafinil 1,325,983 0.2%
Fentanyl 1,296,491 0.2%
Amantadine 1,183,502 0.2%
Naltrexone 1,177,680 0.2%
Carisoprodol 1,132,945 0.2%
Codeine Sulfate 1,043,643 0.2%
Metaxalone 1,031,322 0.2%
Etodolac 951,331 0.2%
Buprenorphine; Naloxone 851,052 0.1%
Acetazolamide 761,295 0.1%
Prochlorperazine 536,923 0.1%
Hydrocodone Bitartrate 404,996 0.1%
Flurbiprofen 381,836 0.1%
Sulindac 219,400 0%
Esomeprazole Magnesium; Naproxen 190,560 0%
Diclofenac Sodium; Misoprostol 157,707 0%
Diflunisal 149,023 0%
Piroxicam 133,990 0%
Famotidine; Ibuprofen 125,181 0%
Testosterone 51,952 0%
Oxaprozin 35,890 0%
Mineral Oil 6,756 0%

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.0. Read more about the ClinCalc DrugStats database.

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Updated Nov 19, 2020
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