Anxiolytics, Sedatives, and Hypnotics

Multum Therapeutic Class Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Alprazolam	15,881,367	18.6%
Hydroxyzine	15,272,377	17.9%
Buspirone	15,229,213	17.9%
Zolpidem	11,424,127	13.4%
Clonazepam	10,614,830	12.5%
Lorazepam	6,963,900	8.2%
Melatonin	3,256,782	3.8%
Doxepin	3,122,268	3.7%
Diazepam	2,711,268	3.2%
Diphenhydramine	707,624	0.8%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Which of these drugs is contraindicated in pregnancy? The Top 250 Drugs by ClinCalc Academy

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Updated Sep 12, 2021

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