Antihistamines

Multum Therapeutic Class Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Hydroxyzine	15,272,377	35.5%
Cetirizine	11,399,498	26.5%
Loratadine	6,699,690	15.6%
Levocetirizine	3,461,898	8%
Fexofenadine	1,951,572	4.5%
Promethazine	1,611,034	3.7%
Cyproheptadine	1,522,003	3.5%
Diphenhydramine	707,624	1.6%
Chlorpheniramine	202,413	0.5%
Carbinoxamine	67,462	0.2%
Desloratadine	63,288	0.1%
Triprolidine	61,711	0.1%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Which of these drugs is contraindicated in pregnancy? The Top 250 Drugs by ClinCalc Academy

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Updated Sep 12, 2021

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