Uncompetitive N-methyl-D-aspartate Receptor Antagonist

Established Pharmacologic Class (EPC) Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Dextromethorphan; Promethazine	1,195,582	52.2%
Brompheniramine; Dextromethorphan; Pseudoephedrine	748,650	32.7%
Dextromethorphan; Guaifenesin	215,014	9.4%
Chlorpheniramine; Dextromethorphan; Phenylephrine	34,304	1.5%
Brompheniramine; Dextromethorphan; Phenylephrine	29,387	1.3%
Dextromethorphan; Guaifenesin; Phenylephrine	27,074	1.2%
Dextromethorphan; Guaifenesin; Pseudoephedrine	23,464	1%
Dextromethorphan	15,611	0.7%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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