Tricyclic Antidepressant

Established Pharmacologic Class (EPC) Comparison, United States, 2022

Total Prescriptions in (2022)

Drug Name Total Prescriptions (2022) Percent Share
Amitriptyline 7,887,977 66.4%
Nortriptyline 2,256,836 19%
Doxepin 1,729,966 14.6%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021
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