Nonsteroidal Anti-inflammatory Drug

Established Pharmacologic Class (EPC) Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Meloxicam	20,703,690	26.3%
Ibuprofen	17,525,800	22.3%
Aspirin	14,095,182	17.9%
Diclofenac	9,438,697	12%
Naproxen	6,808,487	8.7%
Celecoxib	6,190,144	7.9%
Ketorolac	1,627,126	2.1%
Nabumetone	869,464	1.1%
Indomethacin	593,609	0.8%
Etodolac	450,221	0.6%
Sulindac	168,142	0.2%
Oxaprozin	72,993	0.1%
Diclofenac; Misoprostol	47,412	0.1%
Aspirin; Citric Acid; Sodium Bicarbonate	10,494	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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