Histamine-1 Receptor Antagonist

Established Pharmacologic Class (EPC) Comparison, United States, 2023

Total Prescriptions in (2023)

Drug Name	Total Prescriptions (2023)	Percent Share
Cetirizine	11,399,498	50.3%
Azelastine	3,932,233	17.4%
Levocetirizine	3,461,898	15.3%
Fexofenadine	1,951,572	8.6%
Diphenhydramine	707,624	3.1%
Fexofenadine; Pseudoephedrine	321,775	1.4%
Chlorpheniramine	202,413	0.9%
Mometasone; Olopatadine	169,856	0.8%
Azelastine; Fluticasone	165,218	0.7%
Chlorpheniramine; Phenylephrine	82,066	0.4%
Carbinoxamine	67,462	0.3%
Desloratadine	63,288	0.3%
Diphenhydramine; Zinc	45,761	0.2%
Chlorpheniramine; Dextromethorphan; Phenylephrine	34,304	0.2%
Bepotastine	25,386	0.1%
Hydrocodone; Chlorpheniramine	10,639	0%

Total Prescriptions by Drug Over Time

Drug Class Prescribing Trends Over Time

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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