Drug Usage Statistics, United States, 2008 - 2018

Isotretinoin Summary for 2018

Estimated number of prescriptions in the United States 1,531,101
Top drug rank #280 ( 63)
Average total drug cost $606.5 (USD)
Average out-of-pocket cost $40.87 (USD)

Number of Prescriptions Over Time (2008 - 2018)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2008 319  171
2009 325  6
2010 341  16
2011 450  109
2012 286  164
2013 325  39
Year Rank Change
2014 342  17
2015 283  59
2016 311  28
2017 343  32
2018 280  63

Drug Cost Over Time (2008 - 2018)

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Related Drugs

Drug Name Total Prescriptions (2018)
Isotretinoin (this drug) 1,531,102
Tretinoin 1,264,213
Adapalene 813,116
Adapalene; Benzoyl Peroxide 68,070

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Absorica
  • Absorica LD
  • Accutane
  • Amnesteem
  • Claravis
  • Myorisan
  • Sotret
  • Zenatane
Generic Drug Synonyms and Salts
  • Isotretinoin

FDA Approval Information

Established Pharmacologic Class (EPC): Retinoid
Initial FDA approval date: 5/7/1982
First FDA applicant: Discn
First dosage form: Capsule (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.1. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Which of these drugs is contraindicated in pregnancy? The Top 250 Drugs by ClinCalc Academy
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Updated Jan 18, 2021
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