Drug Usage Statistics, United States, 2013 - 2021

Hydroquinone Summary for 2021

Top drug rank #282 ( 85)
Estimated number of prescriptions in the United States (2021) 802,769
Estimated number of patients in the United States (2021) 545,703
Average total drug cost (USD)  
Per prescription $56.63
Per day of therapy $2.02/day
Average out-of-pocket cost (USD)  
Per prescription $41.35
Per day of therapy $1.37/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2019 399 -
2020 367  32
Year Rank Change
2021 282  85

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Cream 4% 100.0%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Hydroquinone (this drug) 802,769

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Accelerated Dark Spot Corrector
  • Advanced Skin Lightening Serum
  • Alumier MD Lightening
  • Balancer
  • Best Age Spot Remover
  • Body Merry Lightening And Whitening Cream
  • Bright Malika And Khadija Brightening Spot Treatment
  • Cicatricure Skin Lightening
  • Corrector 2
  • Differin Dark Spot Correcting Serum
  • Dolly Intense Lightening
  • Double White
  • DR. Lightening Ultra-potent Facial
  • Dual Action Skin Lightener
  • Eb5 Age Spot Treatment
  • Even Tone Night Treatment
  • Fair And White
  • Glytone Dark Spot Corrector
  • Glytone Skin Lightening
  • Glytone Sunvanish Skin Lightening
  • HQ Plus Brightening Cream
  • Hqla
  • Hydro-q
  • Hydroquinone 4%
  • Hyperpigmentation Treatment
  • Lightening HQ Spot
  • Lumipearl Dark Mark Corrector
  • MD Acne Medicated Dark Spot Remover
  • Meditowel
  • New York Fair And Lovely
  • Next Generation Correct Brightening Serum
  • Nova Complex HQ
  • NU-derm Blender
  • NU-derm Clear
  • Obagi C RX System C Clarifying Serum
  • Obagi-c RX System C-clarifying Serum Normal TO Oily
  • Obagi-c RX System C-therapy Night
  • Olivia Quido Skincare Blemish Eraser
  • Pharmaskincare Parfait Lightening Serum
  • Pharmaskincare Serum Skin Lightening
  • Pigment
  • Plexaderm Dark Spot Fade Gel
  • Proactiv Advanced Dark Spot Correcting Serum
  • Skin Lightener
  • Skin Lightening Complex
  • Slmd Skincare BY Sandra Lee, M.D. - Dark Spot Fix
  • Spotfade Dark Spot Wand
  • Teatrical Pro-aclarant Skin Lightening
  • Teatrical Skin Lightening
  • Ultra-potent Brightening Serum
  • ZO Skin Health Pigment Control Creme Hydroquinone
  • ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone
  • ZO Skin Health Pigment Control Plus Brightening Creme Hydroquinone Plus Vitamin C
  • ZO Skin Health Pigment Control Program Plus Hydroquinone
Generic Drug Synonyms and Salts
  • Hydroquinone

FDA Approval Information

Established Pharmacologic Class (EPC): Melanin Synthesis Inhibitor
Initial FDA approval date: 1/18/2002
First FDA applicant: Rx
First dosage form: Cream (topical)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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