Fluticasone Propionate; Salmeterol Xinafoate

Drug Usage Statistics, United States, 2008 - 2018

Fluticasone Propionate; Salmeterol Xinafoate Summary for 2018

Top drug rank #69 ( 4)
Estimated number of prescriptions in the United States (2018) 11,512,537
Estimated number of patients in the United States (2018) 2,447,427
Average total drug cost (USD)  
Per prescription $595.54
Per day of therapy $14.13/day
Average out-of-pocket cost (USD)  
Per prescription $48.11
Per day of therapy $1.29/day

Total Prescriptions and Patients Per Year (2008 - 2018)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2008 87  3
2009 25  62
2010 25 0
2011 28  3
2012 37  9
2013 41  4
Year Rank Change
2014 49  8
2015 51  2
2016 62  11
2017 65  3
2018 69  4

Drug Cost Over Time (2008 - 2018)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

NADAC (National Average Drug Acquisition Cost)

NADAC is the approximate cost of a medication that pharmacies (not patients) pay for a medication in the United States. Cost data is obtained via monthly surveys of community pharmacies. NADAC pricing is considered a more accurate alternative than average wholesale price (AWP). For more information, see NADAC (from Data.Medicaid.gov) or the NADAC data explorer.

NADAC prices vary by NDC (national drug code number), manufacturer, quanity of medication per bottle, and many other factors. The cost data displayed below represents the average pharmacy acquisition cost over the past 90 days.

Description Avg NADAC Price Pricing Unit

Distribution of Dispensed Dosage Forms (2018)

Dosage Form Strength % of Dispensed Products
Inhalation 500-50 mcg 54.5%
Inhalation 100/50 mcg/mcg 18.2%
Inhalation 115/21 mcg/mcg 18.2%
Inhalation 250/50 g/g 9.1%

Distribution of Days Supplied (2018)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2018)
Albuterol 60,526,457
Fluticasone 34,253,764
Prednisone 27,057,495
Budesonide; Formoterol 12,339,320
Fluticasone Propionate; Salmeterol Xinafoate (this drug) 11,512,538
Triamcinolone 6,848,479
Prednisolone 5,202,601
Albuterol Sulfate; Ipratropium Bromide 4,789,979
Hydrocortisone 4,530,985
Methylprednisolone 4,045,962
Budesonide 3,312,208
Beclomethasone 2,724,773
Clobetasol Propionate 2,652,283
Mometasone 2,464,821
Betamethasone 1,920,813
Umeclidinium Bromide; Vilanterol Trifenatate 1,821,792
Bromfenac Sodium; Prednisolone Acetate; Gatifloxacin 1,638,403
Dexamethasone 1,417,571
Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate 1,261,713
Betamethasone Dipropionate; Clotrimazole 1,197,968
Levalbuterol 1,155,526
Fluocinonide 1,093,906
Loteprednol Etabonate 824,256
Dexamethasone; Tobramycin 727,206
Desonide 430,524
Azelastine; Fluticasone 363,053
Neomycin; Polymyxin B; Hydrocortisone 10,381

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Advair Diskus 100/50
  • Advair Diskus 250/50
  • Advair Diskus 500/50
  • Advair Hfa
  • Airduo Digihaler
  • Airduo Respiclick
  • Wixela Inhub
Generic Drug Synonyms and Salts
  • Salmeterol Xinafoate; Fluticasone Propionate
  • Fluticasone Propionate; Salmeterol Xinafoate

FDA Approval Information

Established Pharmacologic Class (EPC): Corticosteroid, beta2-Adrenergic Agonist
Initial FDA approval date: 8/24/2000
First FDA applicant: Rx
First dosage form: Powder (inhalation)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.2. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Jul 3, 2021
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