Fluocinolone; Hydroquinone; Tretinoin

Drug Usage Statistics, United States, 2013 - 2020

Fluocinolone; Hydroquinone; Tretinoin Summary for 2020

Top drug rank #430 (no previous rank)
Estimated number of prescriptions in the United States (2020) 100,586
Estimated number of patients in the United States (2020) 77,782
Average total drug cost (USD)  
Per prescription $229.13
Per day of therapy $7.64/day
Average out-of-pocket cost (USD)  
Per prescription $101.80
Per day of therapy $3.39/day

Total Prescriptions and Patients Per Year (2013 - 2020)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2020 430 -

Drug Cost Over Time (2013 - 2020)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2020)

No data available

Distribution of Days Supplied (2020)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2020)
Fluticasone 24,777,490
Prednisone 19,044,927
Fluticasone; Salmeterol 11,577,409
Budesonide; Formoterol 11,114,690
Triamcinolone 6,422,562
Fluticasone; Vilanterol 5,678,546
Hydrocortisone 3,998,412
Prednisolone 3,894,469
Methylprednisolone 3,535,988
Clobetasol 3,395,469
Budesonide 2,337,016
Beclomethasone 2,184,210
Fluticasone; Umeclidinium; Vilanterol 2,125,888
Tretinoin 2,045,305
Mometasone 1,954,899
Betamethasone 1,934,651
Isotretinoin 1,572,313
Dexamethasone 1,353,240
Fluocinonide 1,282,149
Dexamethasone; Moxifloxacin 1,237,556
Formoterol; Mometasone 1,218,644
Betamethasone; Clotrimazole 1,007,453
Neomycin; Polymyxin B; Hydrocortisone 949,592
Dexamethasone; Neomycin; Polymyxin B 706,702
Dexamethasone; Tobramycin 527,467
Hydroquinone 484,505
Ciprofloxacin; Dexamethasone 420,670
Azelastine; Fluticasone 369,392
Adapalene; Benzoyl Peroxide 309,797
Desonide 295,846
Adapalene 238,869
Flunisolide 103,220
Fluocinolone; Hydroquinone; Tretinoin (this drug) 100,587
Tazarotene 14,361

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Tri-luma
Generic Drug Synonyms and Salts
  • Fluocinolone Acetonide; Hydroquinone; Tretinoin
  • Fluocinolone; Hydroquinone; Tretinoin

FDA Approval Information

Established Pharmacologic Class (EPC): Corticosteroid, Melanin Synthesis Inhibitor, Retinoid
Initial FDA approval date: 1/18/2002
First FDA applicant: Rx
First dosage form: Cream (topical)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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