Drug Usage Statistics, United States, 2013 - 2021

Epinephrine Summary for 2021

Top drug rank #221 ( 30)
Estimated number of prescriptions in the United States (2021) 1,896,954
Estimated number of patients in the United States (2021) 1,432,804
Average total drug cost (USD)  
Per prescription $417.75
Per day of therapy $218.29/day
Average out-of-pocket cost (USD)  
Per prescription $43.87
Per day of therapy $12.25/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 319  36
2014 298  21
2015 321  23
2016 256  65
Year Rank Change
2017 268  12
2018 245  23
2019 253  8
2020 251  2
2021 221  30

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Injection 0.3/0.3 mg/ml 87.7%
Injection 0.15/0.3 mg/ml 5.6%
Other, unspecified, or misc. 6.7%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Adrenaclick
  • Adrenalin
  • Auvi-q
  • Bronkaid Mist
  • Epi E Z Pen JR
  • Epinephrine (Autoinjector)
  • Epipen
  • Epipen E Z Pen
  • Epipen JR.
  • Primatene Mist
  • Sus-phrine Sulfite Free
  • Symjepi
  • Twinject 0.15
  • Twinject 0.3
  • Bronitin Mist
  • Medihaler-epi
  • Crown-pak Max 4-ply
  • Gingi-pak Cotton Coil
  • Gingi-pak Max 2-ply
  • Gingi-pak Max Soft-twist NO 1
  • Gingi-pak Max Soft-twist NO 2
  • Gingi-pak Max Soft-twist NO 3
  • Gingi-pak Max Z-twist NO 00
  • Gingi-pak Max Z-twist NO 1
  • Gingi-pak Max Z-twist NO 2
  • Gingi-pak Max Z-twist NO 3
  • Gingi-pak Pellets
  • Orostat 8%
Generic Drug Synonyms and Salts
  • Epinephrine Bitartrate
  • Epinephrine Hydrochloride
  • Epinephrine

FDA Approval Information

Established Pharmacologic Class (EPC): alpha-Adrenergic Agonist, beta-Adrenergic Agonist, Catecholamine
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Injectable (injection)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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