Diphenhydramine; Zinc

Drug Usage Statistics, United States, 2014 - 2023

Diphenhydramine; Zinc Summary for 2023

Top drug rank	#355 (no previous rank)
Estimated number of prescriptions in the United States (2023)	45,761
Estimated number of patients in the United States (2023)	28,713

Average total drug cost (USD)
Per prescription	$6.70
Per day of therapy	$0.20/day
Average out-of-pocket cost (USD)
Per prescription	$5.02
Per day of therapy	$0.20/day

Total Prescriptions and Patients Per Year (2014 - 2023)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2021	404	-

Year	Rank	Change
2023	355	-

Drug Cost Over Time (2014 - 2023)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2023)

No data available

Distribution of Days Supplied (2023)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2023)
Cetirizine	11,399,498
Azelastine	3,932,233
Levocetirizine	3,461,898
Fexofenadine	1,951,572
Diphenhydramine	707,624
Zinc	323,574
Fexofenadine; Pseudoephedrine	321,775
Chlorpheniramine	202,413
Mometasone; Olopatadine	169,856
Azelastine; Fluticasone	165,218
Chlorpheniramine; Phenylephrine	82,066
Carbinoxamine	67,462
Desloratadine	63,288
Diphenhydramine; Zinc (this drug)	45,761
Chlorpheniramine; Dextromethorphan; Phenylephrine	34,304
Bepotastine	25,386
Hydrocodone; Chlorpheniramine	10,639

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Anti Itch
Anti-itch
Anti-itch Cream
Astonea Extra Strength Anti-itch Cream
Banophen
Benadryl Extra Strength
Benadryl Extra Strength Itch Cooling
Benadryl Extra Strength Itch Relief
Benadryl Original Strength Itch Stopping
Best Choice Itch Relief
Careall Anti-itch
Caring Mill Anti-itch Cream
Cvs Extra Strength Itch Stopping
Cvs Itch Relief
Cvs Regular Strength Itch Stopping
Dermamine
DG Anti-itch
Diphenhydramine Hcl And Zinc Acetate
Discount Drug Mart Extra Strength Itch Stopping
Discount Drug Mart Regular Strength Itch Stopping
DR. Sheffield Anti Itch Cream
Equate Anti Itch
Extra Strength
Extra Strength Itch Relief
Extra Strength Wal-dryl Itch Relief
Family Wellness
Foster And Thrive Anti Itch Cream
Good Neighbor Pharmacy Itch Relief
Good Sense Itch Relief
Goodsense Anti-itch
Itch Relief
Itch Relief Cream
Itch Stopping Cream
Leader Anti Itch
Quality Choice Itch Relief
Rite Aid Extra Strength Itch Stopping
Rite Aid Itch Relief
Savvy
Shopko Anti-itch
Signature Care Itch Relief
Sunmark
Topcare Anti Itch
UP And UP Itch Relief
Walgreens Anti Itch Cream
Walgreens Original Strength Anti Itch
Warrior First Aid Anti Itch
Weeks And Leo Extra Strength Itch Stopping
Welly Calm Balm
Westlake Itch Relief
Winco Original Strength Anti-itch

Generic Drug Synonyms and Salts

Diphenhydramine Hydrochloride; Zinc Acetate
Diphenhydramine; Zinc Acetate
Zinc Acetate; Diphenhydramine Hydrochloride
Diphenhydramine; Zinc

FDA Approval Information

Established Pharmacologic Class (EPC):	Copper Absorption Inhibitor, Histamine-1 Receptor Antagonist
Initial FDA approval date:	6/8/2005
First FDA applicant:	Cvs Pharmacy
First dosage form:	Cream (topical)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Diphenhydramine; Zinc

Drug Usage Statistics, United States, 2014 - 2023

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