Diphenhydramine Hydrochloride

Drug Usage Statistics, United States, 2008 - 2018

Diphenhydramine Hydrochloride Summary for 2018

Estimated number of prescriptions in the United States 1,805,034
Top drug rank #258 ( 17)
Average total drug cost $9 (USD)
Average out-of-pocket cost $0.6 (USD)

Number of Prescriptions Over Time (2008 - 2018)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2008 238  63
2009 248  10
2010 274  26
2011 249  25
2012 259  10
2013 275  16
Year Rank Change
2014 198  77
2015 221  23
2016 210  11
2017 241  31
2018 258  17

Drug Cost Over Time (2008 - 2018)

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Antitussive
  • Beldin
  • Belix
  • Benadryl
  • Benadryl Preservative Free
  • Benylin
  • Dibenil
  • Diphen
  • Diphenhydramine Hydrochloride Preservative Free
  • Hydramine
  • Silphen
  • Vicks Formula 44
Generic Drug Synonyms and Salts
  • Diphenhydramine Hydrochloride

FDA Approval Information

Established Pharmacologic Class (EPC): Histamine-1 Receptor Antagonist
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Elixir (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.1. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Jan 18, 2021
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