Brimonidine; Timolol

Drug Usage Statistics, United States, 2013 - 2019

Brimonidine; Timolol Summary for 2019

Top drug rank #240 ( 62)
Estimated number of prescriptions in the United States (2019) 1,990,438
Estimated number of patients in the United States (2019) 470,874
Average total drug cost (USD)  
Per prescription $365.11
Per day of therapy $6.46/day
Average out-of-pocket cost (USD)  
Per prescription $52.53
Per day of therapy $0.93/day

Total Prescriptions and Patients Per Year (2013 - 2019)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 315  25
2014 292  23
2015 299  7
2016 270  29
Year Rank Change
2017 332  62
2018 302  30
2019 240  62

Drug Cost Over Time (2013 - 2019)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2019)

No data available

Distribution of Days Supplied (2019)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2019)
Metoprolol 74,578,817
Carvedilol 20,602,256
Atenolol 18,091,488
Propranolol 9,277,062
Timolol 3,833,125
Nebivolol 3,061,887
Labetalol 2,825,281
Dorzolamide; Timolol 2,590,910
Brimonidine 2,290,789
Brimonidine; Timolol (this drug) 1,990,438
Bisoprolol 1,863,725
Epinephrine 1,756,817
Bisoprolol; Hydrochlorothiazide 1,433,172
Brompheniramine; Dextromethorphan; Pseudoephedrine 1,396,532
Atenolol; Chlorthalidone 986,436
Nadolol 857,231
Midodrine 804,495
Fexofenadine; Pseudoephedrine 505,003

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Combigan
Generic Drug Synonyms and Salts
  • Brimonidine Tartrate; Timolol Maleate
  • Brimonidine; Timolol

FDA Approval Information

Established Pharmacologic Class (EPC): beta-Adrenergic Blocker, alpha-Adrenergic Agonist
Initial FDA approval date: 10/30/2007
First FDA applicant: Rx
First dosage form: Solution/Drops (ophthalmic)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2019. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2021.10. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


Related Links

Follow Us!

New and Popular


Open Menu

Cite This Page

Show AMA citation

©2022 - ClinCalc LLC. All rights reserved.
Disclaimer - Privacy Policy - Contact Us
Updated Sep 12, 2021
Back to Top