Brimonidine; Timolol

Drug Usage Statistics, United States, 2013 - 2020

Brimonidine; Timolol Summary for 2020

Top drug rank #256 ( 15)
Estimated number of prescriptions in the United States (2020) 1,661,947
Estimated number of patients in the United States (2020) 344,927
Average total drug cost (USD)  
Per prescription $390.68
Per day of therapy $5.89/day
Average out-of-pocket cost (USD)  
Per prescription $50.65
Per day of therapy $0.49/day

Total Prescriptions and Patients Per Year (2013 - 2020)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 315  25
2014 292  23
2015 299  7
2016 271  28
Year Rank Change
2017 332  61
2018 302  30
2019 241  61
2020 256  15

Drug Cost Over Time (2013 - 2020)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2020)

Dosage Form Strength % of Dispensed Products
Solution 0.2-0.6% 100.0%

Distribution of Days Supplied (2020)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2020)
Metoprolol 66,413,693
Carvedilol 23,159,629
Atenolol 12,860,512
Propranolol 8,470,628
Timolol 4,295,413
Brimonidine 3,271,308
Dorzolamide; Timolol 2,482,440
Labetalol 2,301,339
Nebivolol 1,889,275
Epinephrine 1,730,367
Brimonidine; Timolol (this drug) 1,661,947
Bisoprolol 1,467,219
Bisoprolol; Hydrochlorothiazide 1,205,617
Nadolol 738,628
Loratadine; Pseudoephedrine 570,979
Brompheniramine; Dextromethorphan; Pseudoephedrine 556,973
Fexofenadine; Pseudoephedrine 386,927
Pseudoephedrine 278,351
Chlophedianol; Pseudoephedrine; Pyrilamine 195,776
Guaifenesin; Pseudoephedrine 108,699
Cetirizine; Pseudoephedrine 43,538

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Combigan
  • Brimonidine Tartrate And Timolol Maleate
Generic Drug Synonyms and Salts
  • Brimonidine Tartrate; Timolol Maleate
  • Brimonidine; Timolol

FDA Approval Information

Established Pharmacologic Class (EPC): beta-Adrenergic Blocker, alpha-Adrenergic Agonist
Initial FDA approval date: 10/30/2007
First FDA applicant: Rx
First dosage form: Solution/Drops (ophthalmic)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Which of these drugs causes acute kidney injury? The Top 250 Drugs by ClinCalc Academy
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Updated Sep 12, 2021
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