Bisoprolol; Hydrochlorothiazide

Drug Usage Statistics, United States, 2013 - 2020

Bisoprolol; Hydrochlorothiazide Summary for 2020

Top drug rank #290 ( 10)
Estimated number of prescriptions in the United States (2020) 1,205,616
Estimated number of patients in the United States (2020) 299,975
Average total drug cost (USD)  
Per prescription $33.90
Per day of therapy $0.50/day
Average out-of-pocket cost (USD)  
Per prescription $7.24
Per day of therapy $0.07/day

Total Prescriptions and Patients Per Year (2013 - 2020)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 248  137
2014 211  37
2015 246  35
2016 320  74
Year Rank Change
2017 337  17
2018 282  55
2019 280  2
2020 290  10

Drug Cost Over Time (2013 - 2020)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2020)

No data available

Distribution of Days Supplied (2020)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2020)
Metoprolol 66,413,693
Hydrochlorothiazide 41,476,099
Carvedilol 23,159,629
Hydrochlorothiazide; Lisinopril 13,559,564
Atenolol 12,860,512
Propranolol 8,470,628
Hydrochlorothiazide; Losartan 7,948,927
Hydrochlorothiazide; Triamterene 4,783,812
Timolol 4,295,413
Dorzolamide; Timolol 2,482,440
Labetalol 2,301,339
Hydrochlorothiazide; Valsartan 1,914,068
Nebivolol 1,889,275
Brimonidine; Timolol 1,661,947
Bisoprolol 1,467,219
Hydrochlorothiazide; Olmesartan 1,263,816
Bisoprolol; Hydrochlorothiazide (this drug) 1,205,617
Nadolol 738,628

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Bisoprolol Fumarate And Hydrochlorothiazide
  • Ziac
Generic Drug Synonyms and Salts
  • Bisoprolol Fumarate; Hydrochlorothiazide
  • Hydrochlorothiazide; Bisoprolol Fumarate
  • Bisoprolol; Hydrochlorothiazide

FDA Approval Information

Established Pharmacologic Class (EPC): beta-Adrenergic Blocker, Thiazide Diuretic
Initial FDA approval date: 3/26/1993
First FDA applicant: Rx
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2022.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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