Atropine Sulfate; Diphenoxylate Hydrochloride

Drug Usage Statistics, United States, 2007 - 2017

Number of Prescriptions Over Time (2007 - 2017)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2007 229  7
2008 204  25
2009 253  49
2010 298  45
2011 364  66
2012 280  84
Year Rank Change
2013 267  13
2014 314  47
2015 320  6
2016 298  22
2017 353  55

Patient Out-Of-Pocket Cost Over Time (2007 - 2017)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2017)
Tiotropium 9,507,922
Oxybutynin 7,935,806
Albuterol Sulfate; Ipratropium Bromide 3,622,793
Dicyclomine Hydrochloride 3,290,774
Ipratropium 2,397,886
Benztropine Mesylate 2,253,908
Tolterodine Tartrate 2,201,190
Solifenacin Succinate 1,423,778
Umeclidinium Bromide; Vilanterol Trifenatate 1,086,904
Umeclidinium Bromide 995,080
Aclidinium Bromide 917,498
Atropine Sulfate; Diphenoxylate Hydrochloride (this drug) 722,058
Scopolamine 525,018

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Colonaid
  • DI-atro
  • Diphenoxylate Hydrochloride And Atropine Sulfate
  • Diphenoxylate Hydrochloride W/ Atropine Sulfate
  • LO-trol
  • Logen
  • Lomanate
  • Lomotil
  • Lonox
  • Low-quel
Generic Drug Synonyms and Salts
  • Diphenoxylate Hydrochloride; Atropine Sulfate
  • Atropine Sulfate; Diphenoxylate Hydrochloride

FDA Approval Information

Established Pharmacologic Class (EPC): Anticholinergic, Cholinergic Muscarinic Antagonist, Antidiarrheal
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Solution (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2007-2017. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 20.1. Read more about the ClinCalc DrugStats database.


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Which of these drugs is contraindicated in pregnancy? The Top 250 Drugs by ClinCalc Academy
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Updated Jul 19, 2018
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