Atropine; Diphenoxylate

Drug Usage Statistics, United States, 2013 - 2021

Atropine; Diphenoxylate Summary for 2021

Top drug rank #293 ( 28)
Estimated number of prescriptions in the United States (2021) 608,611
Estimated number of patients in the United States (2021) 210,671
Average total drug cost (USD)  
Per prescription $23.72
Per day of therapy $1.87/day
Average out-of-pocket cost (USD)  
Per prescription $5.02
Per day of therapy $0.48/day

Total Prescriptions and Patients Per Year (2013 - 2021)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2013 268  12
2014 321  53
2015 327  6
2016 304  23
Year Rank Change
2017 367  63
2018 364  3
2019 339  25
2020 321  18
2021 293  28

Drug Cost Over Time (2013 - 2021)

  • Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
  • Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

  • Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
  • Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2021)

Dosage Form Strength % of Dispensed Products
Tablet/capsule 2.5-0.025 mg/mg 50.0%
Tablet/capsule 2.5 mg 33.3%
Tablet/capsule 2.6-0.025 mg 16.7%

Distribution of Days Supplied (2021)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name Total Prescriptions (2021)
Oxybutynin 6,619,470
Tiotropium 4,361,799
Dicyclomine 3,919,946
Albuterol; Ipratropium 3,876,202
Fluticasone; Umeclidinium; Vilanterol 2,927,506
Umeclidinium; Vilanterol 2,042,595
Solifenacin 1,791,636
Ipratropium 1,074,166
Atropine; Diphenoxylate (this drug) 608,612
Crofelemer 63,148

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Colonaid
  • DI-atro
  • Diphenoxylate Hydrochloride And Atropine Sulfate
  • Diphenoxylate Hydrochloride W/ Atropine Sulfate
  • LO-trol
  • Logen
  • Lomanate
  • Lomotil
  • Lonox
  • Low-quel
Generic Drug Synonyms and Salts
  • Atropine Sulfate; Diphenoxylate Hydrochloride
  • Diphenoxylate Hydrochloride; Atropine Sulfate
  • Diphenoxylate; Atropine
  • Atropine; Diphenoxylate

FDA Approval Information

Established Pharmacologic Class (EPC): Anticholinergic, Cholinergic Muscarinic Antagonist, Antidiarrheal
Initial FDA approval date: Prior to January 1, 1982
First FDA applicant: Discn
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2021. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.01. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).


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Updated Sep 12, 2021
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