Acetaminophen; Butalbital; Caffeine

Drug Usage Statistics, United States, 2014 - 2024

Acetaminophen; Butalbital; Caffeine Summary for 2024

Top drug rank	#265 ( 3)
Estimated number of prescriptions in the United States (2024)	1,242,180
Estimated number of patients in the United States (2024)	571,836

Average total drug cost (USD)
Per prescription	$19.27
Per day of therapy	$3.18/day
Average out-of-pocket cost (USD)
Per prescription	$12.69
Per day of therapy	$2.04/day

Total Prescriptions and Patients Per Year (2014 - 2024)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2014	244	48
2015	213	31
2016	201	12
2017	187	14
2018	185	2
2019	229	44

Year	Rank	Change
2020	201	28
2021	232	31
2022	248	16
2023	262	14
2024	265	3

Drug Cost Over Time (2014 - 2024)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypertensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2024)

No data available

Distribution of Days Supplied (2024)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2024)
Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	36,846,046
Methylphenidate	18,572,946
Lisdexamfetamine	9,929,931
Dexmethylphenidate	4,033,754
Dextroamphetamine	1,858,742
Acetaminophen; Butalbital; Caffeine (this drug)	1,242,180

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Anoquan
Butalbital, Acetaminophen And Caffeine
Esgic
Esgic-plus
Femcet
Medigesic Plus
Triad

Generic Drug Synonyms and Salts

Acetaminophen; Butalbital; Caffeine

FDA Approval Information

Established Pharmacologic Class (EPC):	Barbiturate, Central Nervous System Stimulant, Methylxanthine
Initial FDA approval date:	11/9/1984
First FDA applicant:	Rx
First dosage form:	Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2024. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2026.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Apr 15, 2025

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Acetaminophen; Butalbital; Caffeine

Drug Usage Statistics, United States, 2014 - 2024

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