ClinCalc DrugStats Database

Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Annual Change
1 Atorvastatin 112,474,023  1
2 Levothyroxine 105,773,990  1
3 Lisinopril 97,608,879  2
4 Metformin Hydrochloride 83,762,981 0
5 Amlodipine 75,811,947 0
6 Metoprolol 71,581,961 0
7 Albuterol 60,526,457  3
8 Omeprazole 58,364,556  1
9 Losartan Potassium 50,479,750 0
10 Simvastatin 48,007,043  2
11 Gabapentin 45,586,654 0
12 Acetaminophen; Hydrocodone Bitartrate 42,073,176  1
13 Hydrochlorothiazide 40,575,075  1
14 Sertraline Hydrochloride 38,383,042 0
15 Montelukast 35,222,630  1
16 Fluticasone 34,253,764  1
17 Amoxicillin 31,371,675  1
18 Furosemide 29,857,945  1
19 Pantoprazole Sodium 28,958,134 0
20 Acetaminophen 27,907,360  5
21 Prednisone 27,057,494  1
22 Escitalopram Oxalate 25,978,773  2
23 Fluoxetine Hydrochloride 25,619,277  8
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775  3
25 Tramadol Hydrochloride 24,952,328  7
26 Insulin Glargine 24,911,721  7
27 Bupropion 24,488,843  4
28 Ibuprofen 24,453,501 0
29 Rosuvastatin 24,138,061  10
30 Pravastatin Sodium 24,022,031  6
31 Trazodone Hydrochloride 23,889,624  1
32 Tamsulosin Hydrochloride 23,254,004  3
33 Carvedilol 22,737,638  4
34 Meloxicam 22,610,690  4
35 Citalopram 22,224,263  9
36 Duloxetine 21,217,653  10
37 Alprazolam 20,843,479  16
38 Potassium 20,414,037  1
39 Clopidogrel Bisulfate 20,016,095  1
40 Aspirin 19,750,180  2
41 Ranitidine 18,739,686  7
42 Atenolol 18,644,884  6
43 Cyclobenzaprine 18,041,836 0
44 Glipizide 17,549,602  1
45 Methylphenidate 17,467,265  2
46 Azithromycin 17,102,628  11
47 Clonazepam 17,064,643  13
48 Oxycodone 16,967,479  4
49 Allopurinol 16,374,431  5
50 Venlafaxine 16,121,149  1
51 Hydrochlorothiazide; Lisinopril 15,932,877  7
52 Warfarin 14,772,355  1
53 Propranolol Hydrochloride 14,571,767  12
54 Hydrochlorothiazide; Losartan Potassium 13,880,262  13
55 Cetirizine 13,799,351  11
56 Estradiol 13,583,025  5
57 Ethinyl Estradiol; Norethindrone 13,509,602  4
58 Lorazepam 13,222,989  2
59 Quetiapine Fumarate 12,962,563  18
60 Zolpidem Tartrate 12,877,940  10
61 Ergocalciferol 12,831,209  6
62 Budesonide; Formoterol 12,339,319  13
63 Spironolactone 12,260,624  6
64 Ondansetron 12,240,225  19
65 Insulin Aspart 12,146,568  9
66 Apixaban 12,113,153  27
67 Naproxen 11,942,765  5
68 Lamotrigine 11,582,775  5
69 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537  4
70 Pregabalin 11,429,654  3
71 Glimepiride 11,405,689  7
72 Diclofenac 11,372,069  22
73 Fenofibrate 11,325,402  3
74 Paroxetine 11,228,908  6
75 Clonidine 11,141,934  4
76 Loratadine 10,528,684  17
77 Diltiazem Hydrochloride 10,505,373  1
78 Hydroxyzine 10,431,206  21
79 Amitriptyline 10,282,767  8
80 Doxycycline 10,191,744  33
81 Ethinyl Estradiol; Norgestimate 10,166,878  19
82 Lisdexamfetamine Dimesylate 10,011,145  9
83 Sitagliptin Phosphate 9,813,527  12
84 Latanoprost 8,975,788  3
85 Cephalexin 8,938,064  17
86 Tizanidine 8,901,700  3
87 Finasteride 8,876,331  1
88 Lovastatin 8,769,143  4
89 Topiramate 8,648,513  11
90 Insulin Lispro 8,512,587  34
91 Sulfamethoxazole; Trimethoprim 8,448,278  30
92 Buspirone Hydrochloride 8,149,119  12
93 Oseltamivir Phosphate 8,139,836  66
94 Ferrous Sulfate 8,076,467  2
95 Amoxicillin; Clavulanate Potassium 7,974,978  21
96 Valsartan 7,694,037  11
97 Levetiracetam 7,666,166  13
98 Hydralazine Hydrochloride 7,545,026  7
99 Mirtazapine 7,504,257  20
100 Rivaroxaban 7,429,839  9
101 Aripiprazole 7,406,248  11
102 Oxybutynin 7,339,185  2
103 Esomeprazole 7,227,318  15
104 Alendronate Sodium 7,119,333  14
105 Folic Acid 7,099,659  9
106 Triamcinolone 6,848,479  3
107 Tiotropium 6,762,985  25
108 Thyroid 6,741,066  22
109 Ciprofloxacin 6,736,471  2
110 Isosorbide Mononitrate 6,698,824  1
111 Sumatriptan 6,674,685  14
112 Insulin Detemir 6,593,849  2
113 Benzonatate 6,493,593  35
114 Famotidine 6,470,718  1
115 Diazepam 6,448,085  20
116 Ropinirole Hydrochloride 6,224,574  8
117 Hydrochlorothiazide; Triamterene 6,007,404  16
118 Benazepril Hydrochloride 5,920,052  14
119 Metronidazole 5,852,534  61
120 Methocarbamol 5,849,167  58
121 Nifedipine 5,649,892  1
122 Baclofen 5,642,530  18
123 Methotrexate 5,518,246  6
124 Testosterone 5,483,791  8
125 Ezetimibe 5,476,606  26
126 Celecoxib 5,445,346  20
127 Guanfacine 5,429,776  4
128 Donepezil Hydrochloride 5,412,435  1
129 Hydroxychloroquine 5,406,190  1
130 Clindamycin 5,375,352  7
131 Divalproex Sodium 5,275,298  5
132 Morphine 5,225,088  23
133 Ethinyl Estradiol; Levonorgestrel 5,222,138  3
134 Prednisolone 5,202,600  5
135 Enalapril Maleate 5,182,854  13
136 Pioglitazone 5,178,776  11
137 Cyanocobalamin 5,107,466  33
138 Norethindrone 5,100,249  3
139 Meclizine Hydrochloride 4,960,255  22
140 Valacyclovir 4,931,639  12
141 Albuterol Sulfate; Ipratropium Bromide 4,789,978  31
142 Docusate 4,788,381  19
143 Liraglutide 4,771,233  20
144 Hydrocortisone 4,530,984  10
145 Verapamil Hydrochloride 4,492,362 0
146 Cefdinir 4,361,025  52
147 Nortriptyline Hydrochloride 4,346,899  36
148 Timolol 4,312,018  2
149 Dulaglutide 4,223,559  83
150 Promethazine Hydrochloride 4,171,551  3
151 Acyclovir 4,170,803  15
152 Fluconazole 4,115,042  30
153 Methylprednisolone 4,045,962  4
154 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205  15
155 Ramipril 3,989,667  21
156 Dexmethylphenidate Hydrochloride 3,961,348  33
157 Brimonidine Tartrate 3,929,927  10
158 Oxcarbazepine 3,915,508  49
159 Risperidone 3,909,621  3
160 Levofloxacin 3,892,600  5
161 Chlorthalidone 3,883,003  12
162 Atomoxetine Hydrochloride 3,848,913  37
163 Polyethylene Glycol 3350 3,829,568  1
164 Calcium; Cholecalciferol 3,824,225  72
165 Mupirocin 3,798,015  21
166 Ethinyl Estradiol; Etonogestrel 3,772,808  11
167 Drospirenone; Ethinyl Estradiol 3,759,495  69
168 Phentermine 3,683,239  42
169 Carbidopa; Levodopa 3,638,766  15
170 Omega-3-acid Ethyl Esters 3,635,260  12
171 Desogestrel; Ethinyl Estradiol 3,633,965  7
172 Guaifenesin 3,578,369  62
173 Rizatriptan Benzoate 3,490,815  31
174 Irbesartan 3,490,431  46
175 Progesterone 3,436,339  20
176 Doxazosin Mesylate 3,417,127  26
177 Linagliptin 3,390,520  23
178 Adalimumab 3,369,130  9
179 Nitrofurantoin 3,364,026  6
180 Budesonide 3,312,207  10
181 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178  21
182 Hydrochlorothiazide; Valsartan 3,261,560  49
183 Digoxin 3,251,214  15
184 Acetaminophen; Butalbital 3,242,635  3
185 Insulin Degludec 3,226,387  80
186 Ketoconazole 3,222,574  33
187 Nitroglycerin 3,182,971  44
188 Temazepam 3,173,561  46
189 Amiodarone Hydrochloride 3,171,077  7
190 Memantine Hydrochloride 3,129,750  41
191 Canagliflozin 3,108,372  1
192 Ketorolac Tromethamine 3,085,293  79
193 Liothyronine Sodium 3,081,151  59
194 Lithium 3,077,611  14
195 Dicyclomine Hydrochloride 3,076,088  14
196 Pramipexole Dihydrochloride 2,984,633  17
197 Nebivolol Hydrochloride 2,955,158  53
198 Terazosin 2,954,414  4
199 Magnesium 2,940,781  28
200 Colchicine 2,925,875  1

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.1. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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