ClinCalc DrugStats Database

Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Annual Change
1 Atorvastatin 112,474,023  1
2 Lisinopril 97,608,879  1
3 Metformin Hydrochloride 83,762,981  1
4 Amlodipine 75,811,947  1
5 Metoprolol 71,581,961  1
6 Albuterol 60,526,457  4
7 Omeprazole 58,364,556 0
8 Losartan Potassium 50,479,750  1
9 Simvastatin 48,007,043  1
10 Gabapentin 45,586,654  1
11 Acetaminophen; Hydrocodone Bitartrate 42,073,176  2
12 Hydrochlorothiazide 40,575,075 0
13 Sertraline Hydrochloride 38,383,042  1
14 Montelukast 35,222,630  2
15 Fluticasone 34,253,764 0
16 Amoxicillin 31,371,675  2
17 Furosemide 29,857,945 0
18 Pantoprazole Sodium 28,958,134  1
19 Acetaminophen 27,907,360  6
20 Prednisone 27,057,494  2
21 Escitalopram Oxalate 25,978,773  1
22 Fluoxetine Hydrochloride 25,619,277  9
23 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775  4
24 Tramadol Hydrochloride 24,952,328  8
25 Insulin Glargine 24,911,721  8
26 Bupropion 24,488,843  3
27 Ibuprofen 24,453,501  1
28 Rosuvastatin 24,138,061  11
29 Pravastatin Sodium 24,022,031  5
30 Trazodone Hydrochloride 23,889,624 0
31 Tamsulosin Hydrochloride 23,254,004  4
32 Carvedilol 22,737,638  3
33 Meloxicam 22,610,690  5
34 Citalopram 22,224,263  8
35 Duloxetine 21,217,653  11
36 Alprazolam 20,843,479  15
37 Clopidogrel Bisulfate 20,016,095  3
38 Aspirin 19,750,180  4
39 Ranitidine 18,739,686  9
40 Atenolol 18,644,884  4
41 Cyclobenzaprine 18,041,836  2
42 Glipizide 17,549,602  3
43 Methylphenidate 17,467,265  4
44 Azithromycin 17,102,628  13
45 Clonazepam 17,064,643  11
46 Oxycodone 16,967,479  6
47 Allopurinol 16,374,431  7
48 Venlafaxine 16,121,149  1
49 Hydrochlorothiazide; Lisinopril 15,932,877  5
50 Warfarin 14,772,355  1
51 Propranolol Hydrochloride 14,571,767  10
52 Hydrochlorothiazide; Losartan Potassium 13,880,262  15
53 Cetirizine 13,799,351  13
54 Estradiol 13,583,025  7
55 Ethinyl Estradiol; Norethindrone 13,509,602  2
56 Lorazepam 13,222,989  4
57 Quetiapine Fumarate 12,962,563  19
58 Zolpidem Tartrate 12,877,940  8
59 Ergocalciferol 12,831,209  4
60 Budesonide; Formoterol 12,339,319  14
61 Spironolactone 12,260,624  8
62 Ondansetron 12,240,225  21
63 Insulin Aspart 12,146,568  7
64 Apixaban 12,113,153  29
65 Naproxen 11,942,765  6
66 Lamotrigine 11,582,775  3
67 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537  2
68 Pregabalin 11,429,654  4
69 Glimepiride 11,405,689  5
70 Diclofenac 11,372,069  24
71 Fenofibrate 11,325,402  1
72 Paroxetine 11,228,908  4
73 Clonidine 11,141,934  6
74 Loratadine 10,528,684  15
75 Diltiazem Hydrochloride 10,505,373 0
76 Hydroxyzine 10,431,206  23
77 Amitriptyline 10,282,767  10
78 Doxycycline 10,191,744  35
79 Ethinyl Estradiol; Norgestimate 10,166,878  17
80 Lisdexamfetamine Dimesylate 10,011,145  11
81 Sitagliptin Phosphate 9,813,527  14
82 Latanoprost 8,975,788  1
83 Cephalexin 8,938,064  19
84 Tizanidine 8,901,700  5
85 Finasteride 8,876,331  1
86 Lovastatin 8,769,143  2
87 Topiramate 8,648,513  10
88 Insulin Lispro 8,512,587  36
89 Sulfamethoxazole; Trimethoprim 8,448,278  32
90 Buspirone Hydrochloride 8,149,119  10
91 Oseltamivir Phosphate 8,139,836  68
92 Amoxicillin; Clavulanate Potassium 7,974,978  24
93 Valsartan 7,694,037  8
94 Levetiracetam 7,666,166  16
95 Hydralazine Hydrochloride 7,545,026  10
96 Mirtazapine 7,504,257  23
97 Rivaroxaban 7,429,839  12
98 Aripiprazole 7,406,248  14
99 Oxybutynin 7,339,185  1
100 Esomeprazole 7,227,318  12
101 Alendronate Sodium 7,119,333  11
102 Folic Acid 7,099,659  6
103 Triamcinolone 6,848,479 0
104 Tiotropium 6,762,985  22
105 Thyroid 6,741,066  25
106 Ciprofloxacin 6,736,471  1
107 Isosorbide Mononitrate 6,698,824  4
108 Sumatriptan 6,674,685  11
109 Insulin Detemir 6,593,849  5
110 Benzonatate 6,493,593  38
111 Famotidine 6,470,718  4
112 Diazepam 6,448,085  23
113 Ropinirole Hydrochloride 6,224,574  5
114 Hydrochlorothiazide; Triamterene 6,007,404  13
115 Benazepril Hydrochloride 5,920,052  11
116 Metronidazole 5,852,534  58
117 Methocarbamol 5,849,167  61
118 Nifedipine 5,649,892  2
119 Baclofen 5,642,530  21
120 Methotrexate 5,518,246  3
121 Ezetimibe 5,476,606  30
122 Celecoxib 5,445,346  16
123 Guanfacine 5,429,776  8
124 Donepezil Hydrochloride 5,412,435  3
125 Hydroxychloroquine 5,406,190  3
126 Clindamycin 5,375,352  11
127 Divalproex Sodium 5,275,298  1
128 Morphine 5,225,088  27
129 Ethinyl Estradiol; Levonorgestrel 5,222,138  7
130 Prednisolone 5,202,600  1
131 Enalapril Maleate 5,182,854  9
132 Pioglitazone 5,178,776  7
133 Cyanocobalamin 5,107,466  37
134 Norethindrone 5,100,249  7
135 Meclizine Hydrochloride 4,960,255  26
136 Valacyclovir 4,931,639  16
137 Albuterol Sulfate; Ipratropium Bromide 4,789,978  35
138 Docusate 4,788,381  15
139 Liraglutide 4,771,233  24
140 Verapamil Hydrochloride 4,492,362  5
141 Cefdinir 4,361,025  57
142 Nortriptyline Hydrochloride 4,346,899  41
143 Timolol 4,312,018  3
144 Dulaglutide 4,223,559  88
145 Promethazine Hydrochloride 4,171,551  2
146 Acyclovir 4,170,803  20
147 Fluconazole 4,115,042  35
148 Methylprednisolone 4,045,962  9
149 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205  10
150 Ramipril 3,989,667  16
151 Dexmethylphenidate Hydrochloride 3,961,348  38
152 Brimonidine Tartrate 3,929,927  15
153 Oxcarbazepine 3,915,508  54
154 Risperidone 3,909,621  2
155 Levofloxacin 3,892,600  10
156 Chlorthalidone 3,883,003  17
157 Atomoxetine Hydrochloride 3,848,913  42
158 Polyethylene Glycol 3350 3,829,568  4
159 Calcium; Cholecalciferol 3,824,225  77
160 Mupirocin 3,798,015  26
161 Ethinyl Estradiol; Etonogestrel 3,772,808  16
162 Drospirenone; Ethinyl Estradiol 3,759,495  64
163 Phentermine 3,683,239  47
164 Carbidopa; Levodopa 3,638,766  20
165 Omega-3-acid Ethyl Esters 3,635,260  7
166 Desogestrel; Ethinyl Estradiol 3,633,965  2
167 Guaifenesin 3,578,369  67
168 Rizatriptan Benzoate 3,490,815  36
169 Irbesartan 3,490,431  51
170 Doxazosin Mesylate 3,417,127  20
171 Linagliptin 3,390,520  29
172 Adalimumab 3,369,130  3
173 Nitrofurantoin 3,364,026  12
174 Budesonide 3,312,207  16
175 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178  15
176 Hydrochlorothiazide; Valsartan 3,261,560  43
177 Digoxin 3,251,214  9
178 Acetaminophen; Butalbital 3,242,635  9
179 Insulin Degludec 3,226,387  86
180 Ketoconazole 3,222,574  39
181 Temazepam 3,173,561  39
182 Amiodarone Hydrochloride 3,171,077  14
183 Hydrocortisone 3,139,816  29
184 Memantine Hydrochloride 3,129,750  35
185 Canagliflozin 3,108,372  7
186 Ketorolac Tromethamine 3,085,293  85
187 Liothyronine Sodium 3,081,151  65
188 Lithium 3,077,611  8
189 Dicyclomine Hydrochloride 3,076,088  8
190 Pramipexole Dihydrochloride 2,984,633  11
191 Nebivolol Hydrochloride 2,955,158  47
192 Terazosin 2,954,414  2
193 Colchicine 2,925,875  8
194 Magnesium 2,905,858  23
195 Sucralfate 2,896,601  23
196 Medroxyprogesterone Acetate 2,866,848  26
197 Glyburide 2,841,093  23
198 Carbamazepine 2,840,744  22
199 Gemfibrozil 2,837,065  61
200 Nystatin 2,806,963  30

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.0. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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