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Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2022

Rank Drug Name Total Prescriptions (2022) Total Patients (2022) Annual Change
1 Atorvastatin 109,582,746 27,935,702 0
2 Metformin 86,747,907 19,536,027 0
3 Lisinopril 82,513,967 20,314,304  1
4 Levothyroxine 82,431,914 18,130,331  1
5 Amlodipine 70,766,211 17,789,649 0
6 Metoprolol 65,245,216 15,542,999 0
7 Albuterol 59,075,269 19,265,334 0
8 Losartan 53,555,510 13,150,031 0
9 Omeprazole 52,132,950 13,802,111 0
10 Gabapentin 40,141,486 9,889,546 0
11 Sertraline 39,891,990 8,422,729 0
12 Hydrochlorothiazide 38,153,288 9,758,721 0
13 Rosuvastatin 37,095,971 9,721,324 0
14 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 34,690,297 4,652,545  3
15 Escitalopram 30,750,612 7,493,104 0
16 Pantoprazole 30,670,528 7,979,792  3
17 Montelukast 29,187,952 6,825,788  3
18 Trazodone 27,363,318 5,759,352  4
19 Simvastatin 26,459,069 6,986,630  3
20 Tamsulosin 25,306,357 6,758,617  4
21 Bupropion 25,197,923 6,111,736  3
22 Fluoxetine 24,014,263 5,174,534  3
23 Acetaminophen; Hydrocodone 23,521,228 7,972,417  3
24 Furosemide 23,067,424 5,845,466  3
25 Fluticasone 22,557,458 7,453,010  2
26 Amoxicillin 20,465,164 15,998,871  12
27 Apixaban 19,420,949 4,494,660  6
28 Insulin Glargine 18,983,905 3,808,867  1
29 Meloxicam 18,859,721 6,284,853  3
30 Prednisone 18,201,857 8,722,579  2
31 Duloxetine 18,066,468 4,042,916  4
32 Methylphenidate 17,705,265 2,586,485  11
33 Ibuprofen 17,493,911 9,340,903  3
34 Carvedilol 17,067,595 4,472,118  8
35 Potassium Chloride 16,993,841 4,513,952  5
36 Aspirin 16,981,811 5,095,974  2
37 Pravastatin 16,317,126 3,949,800  2
38 Ergocalciferol 15,914,322 4,987,258  3
39 Allopurinol 15,235,132 3,867,218  1
40 Citalopram 15,047,663 3,540,540  9
41 Alprazolam 14,988,526 3,336,114  1
42 Glipizide 14,521,604 3,697,042  6
43 Cetirizine 13,899,342 4,436,602  6
44 Venlafaxine 13,881,022 2,844,672 0
45 Cyclobenzaprine 13,724,245 5,016,775 0
46 Hydroxyzine 13,652,751 3,675,422  12
47 Clopidogrel 13,568,821 3,767,583  10
48 Semaglutide 13,523,981 3,281,179  42
49 Famotidine 13,156,330 4,182,077  8
50 Estradiol 12,622,775 3,300,902  10
51 Diclofenac 12,480,262 4,295,892  10
52 Spironolactone 12,450,600 3,229,839  2
53 Hydrochlorothiazide; Lisinopril 12,335,355 2,917,147  2
54 Buspirone 12,332,589 2,671,839  1
55 Tramadol 12,203,197 4,050,454  14
56 Empagliflozin 12,009,951 3,063,605  29
57 Clonazepam 11,711,065 1,968,091  11
58 Lamotrigine 11,704,668 1,880,284  8
59 Fluticasone; Salmeterol 11,570,693 3,163,220  5
60 Oxycodone 11,314,082 4,797,946  1
61 Ondansetron 10,880,346 5,755,033  18
62 Cholecalciferol 10,833,991 3,330,178  3
63 Atenolol 10,675,235 2,625,632  16
64 Glimepiride 10,407,351 2,285,854  10
65 Folic Acid 10,185,562 2,602,156  12
66 Zolpidem 9,972,232 1,983,061  3
67 Latanoprost 9,971,002 2,723,057  1
68 Doxycycline 9,833,973 5,787,510  14
69 Lisdexamfetamine 9,791,955 1,529,700 0
70 Insulin Lispro 9,647,313 2,183,803  15
71 Clonidine 9,626,080 1,877,700  9
72 Loratadine 9,230,347 2,593,104  5
73 Finasteride 9,203,008 2,626,865  15
74 Dulaglutide 8,968,874 2,001,700  4
75 Hydrochlorothiazide; Losartan 8,825,878 2,442,356  12
76 Insulin Aspart 8,813,259 1,733,883  5
77 Propranolol 8,810,846 2,153,812  14
78 Azithromycin 8,770,185 7,146,386  19
79 Ezetimibe 8,656,499 2,228,797  13
80 Ethinyl Estradiol; Norethindrone 8,582,372 2,406,285  28
81 Lorazepam 8,502,480 2,170,621  3
82 Quetiapine 8,443,014 1,585,405  20
83 Budesonide; Formoterol 8,225,092 1,875,357  11
84 Topiramate 8,210,654 1,983,577  18
85 Warfarin 8,135,552 1,602,377  29
86 Sitagliptin 7,947,929 1,739,317  3
87 Amitriptyline 7,887,977 1,675,744  20
88 Fenofibrate 7,816,415 1,955,538  7
89 Naproxen 7,381,940 3,270,262  4
90 Rivaroxaban 7,298,837 1,913,151  4
91 Pregabalin 7,167,540 1,601,090  18
92 Paroxetine 7,127,748 1,470,173  3
93 Celecoxib 7,023,511 2,410,924  5
94 Tizanidine 6,971,104 2,286,583  5
95 Sumatriptan 6,899,199 2,105,101  14
96 Amoxicillin; Clavulanate 6,874,603 5,534,480  19
97 Olmesartan 6,554,547 1,703,089  29
98 Acetaminophen; Oxycodone 6,531,255 2,280,831  23
99 Ethinyl Estradiol; Norgestimate 6,339,863 1,867,085  23
100 Diltiazem 6,257,580 1,785,422  16
101 Cephalexin 6,228,250 4,570,468  5
102 Triamcinolone 6,216,924 4,171,508  2
103 Alendronate 6,127,862 1,912,735  9
104 Baclofen 6,099,128 1,603,798  1
105 Mirtazapine 6,069,480 1,310,009  19
106 Aripiprazole 6,053,911 1,275,362  7
107 Ferrous Sulfate 6,042,033 2,327,497  2
108 Chlorthalidone 5,928,576 1,597,980  19
109 Dexmethylphenidate 5,809,075 727,981  12
110 Oxybutynin 5,781,797 1,749,942  8
111 Lovastatin 5,745,441 1,419,808  11
112 Hydroxychloroquine 5,566,988 1,214,358  4
113 Valacyclovir 5,529,292 2,563,195  1
114 Acetaminophen 5,512,120 2,703,476  1
115 Dapagliflozin 5,503,867 1,372,807  72
116 Hydrochlorothiazide; Triamterene 5,500,903 1,489,499  4
117 Valsartan 5,450,866 1,714,202  3
118 Testosterone 5,432,642 1,394,497  25
119 Isosorbide 5,429,185 1,322,047  8
120 Pioglitazone 5,389,600 1,162,718  9
121 Hydralazine 5,298,188 1,544,740  15
122 Esomeprazole 5,207,671 1,215,844  3
123 Levetiracetam 5,202,579 1,182,326  22
124 Azelastine 5,195,092 1,746,057  21
125 Progesterone 5,153,382 1,095,601  42
126 Methocarbamol 5,109,104 2,345,639  3
127 Insulin Detemir 4,867,207 905,394  10
128 Ethinyl Estradiol; Levonorgestrel 4,846,343 1,327,012  16
129 Meclizine 4,776,929 1,493,854  7
130 Benzonatate 4,735,583 3,264,685  28
131 Cyanocobalamin 4,663,173 1,489,713  21
132 Methotrexate 4,565,259 1,077,459 0
133 Metronidazole 4,493,311 2,696,460  61
134 Acyclovir 4,458,457 1,322,764  35
135 Norethindrone 4,337,336 1,420,212  5
136 Prednisolone 4,327,569 2,421,943  17
137 Thyroid 4,312,524 823,819  18
138 Insulin Degludec 4,306,212 903,028  8
139 Liraglutide 4,271,706 789,348  27
140 Morphine 4,101,413 799,046  16
141 Enalapril 4,066,367 906,186  137
142 Drospirenone; Ethinyl Estradiol 4,033,582 972,919  10
143 Sulfamethoxazole; Trimethoprim 3,932,844 2,772,821  21
144 Fluticasone; Umeclidinium; Vilanterol 3,919,607 827,181  29
145 Fluticasone; Vilanterol 3,879,209 945,692  37
146 Donepezil 3,855,535 1,015,233  15
147 Clindamycin 3,855,100 2,369,863  29
148 Docusate 3,801,797 1,558,611  15
149 Phentermine 3,738,423 1,030,978  58
150 Memantine 3,703,293 896,917  20
151 Nifedipine 3,681,537 1,138,199  23
152 Levocetirizine 3,646,727 973,836  38
153 Methylprednisolone 3,595,226 2,813,645  15
154 Tiotropium 3,585,223 916,849  20
155 Timolol 3,536,135 860,252  8
156 Clobetasol 3,528,926 1,930,537  6
157 Sildenafil 3,459,590 1,127,720 0
158 Nitrofurantoin 3,448,530 2,502,989  23
159 Benazepril 3,424,799 993,316  12
160 Fluconazole 3,398,872 2,006,839  5
161 Desogestrel; Ethinyl Estradiol 3,308,281 957,396  24
162 Mupirocin 3,302,563 2,396,124  41
163 Ropinirole 3,241,699 781,835  21
164 Nirmatrelvir; Ritonavir 3,240,848 2,965,795 0
165 Sacubitril; Valsartan 3,183,215 727,811  24
166 Acetaminophen; Codeine 3,179,641 1,402,706  10
167 Oxcarbazepine 3,138,991 623,643  37
168 Cefdinir 3,098,850 2,412,211  29
169 Diazepam 3,093,210 1,011,956  20
170 Amlodipine; Benazepril 3,083,302 839,349  20
171 Olanzapine 3,028,056 443,521  7
172 Tadalafil 3,024,680 709,112  1
173 Nebivolol 3,006,294 724,281  71
174 Valproate 2,969,360 553,891  19
175 Ketoconazole 2,955,996 1,496,073  14
176 Dicyclomine 2,924,051 1,008,828  28
177 Budesonide 2,800,249 864,807  8
178 Albuterol; Ipratropium 2,771,010 794,788  27
179 Anastrozole 2,676,294 623,266  3
180 Doxazosin 2,644,458 659,808  15
181 Ciprofloxacin 2,622,220 1,994,293  40
182 Metformin; Sitagliptin 2,611,967 597,745  28
183 Risperidone 2,609,294 536,202  45
184 Torsemide 2,524,293 631,189  4
185 Cyclosporine 2,478,714 864,942  10
186 Dexlansoprazole 2,454,438 674,083 0
187 Ramipril 2,404,446 558,392  14
188 Verapamil 2,384,033 642,398  8
189 Linaclotide 2,378,887 534,890  57
190 Rizatriptan 2,297,918 588,662  31
191 Nortriptyline 2,256,836 647,355  52
192 Insulin Human; Insulin Isophane Human 2,234,041 447,324  13
193 Pramipexole 2,224,945 654,960  16
194 Ethinyl Estradiol; Etonogestrel 2,217,838 604,521  4
195 Bimatoprost 2,197,512 520,908  9
196 Nitroglycerin 2,158,295 1,227,621  22
197 Colchicine 2,153,766 923,806  13
198 Promethazine 2,149,358 857,334  10
199 Brimonidine 2,126,110 692,801  39
200 Irbesartan 2,067,518 566,827  28

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Jan 1, 2024
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