ClinCalc DrugStats Database

Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2020

Rank Drug Name Total Prescriptions (2017) Annual Change
1 Lisinopril 104,779,318  1
2 Atorvastatin 104,774,006  1
3 Levothyroxine 101,932,430  2
4 Metformin Hydrochloride 78,602,870 0
5 Amlodipine 72,508,878 0
6 Metoprolol 68,076,156 0
7 Omeprazole 58,837,874 0
8 Simvastatin 56,708,617 0
9 Losartan Potassium 51,989,444 0
10 Albuterol 50,286,686 0
11 Gabapentin 46,043,168 0
12 Hydrochlorothiazide 42,037,081 0
13 Acetaminophen; Hydrocodone Bitartrate 40,123,144 0
14 Sertraline Hydrochloride 38,296,630 0
15 Fluticasone 32,049,111  1
16 Montelukast 31,953,728  7
17 Furosemide 30,583,265  2
18 Amoxicillin 27,913,807 0
19 Pantoprazole Sodium 27,081,977  6
20 Escitalopram Oxalate 25,960,468  6
21 Alprazolam 25,516,329  2
22 Prednisone 25,028,445  9
23 Bupropion 24,903,971  5
24 Pravastatin Sodium 24,812,698  3
25 Acetaminophen 24,742,095  8
26 Citalopram 24,434,272  5
27 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 24,155,783  18
28 Ibuprofen 24,070,989  7
29 Carvedilol 22,974,069  1
30 Trazodone Hydrochloride 22,311,417  6
31 Fluoxetine Hydrochloride 21,913,275  2
32 Tramadol Hydrochloride 21,096,312  7
33 Insulin Glargine 20,715,011  11
34 Clonazepam 20,708,621  8
35 Tamsulosin Hydrochloride 20,313,916  3
36 Atenolol 20,208,476  16
37 Potassium 19,821,825  4
38 Meloxicam 19,793,506  2
39 Rosuvastatin 19,628,896  2
40 Clopidogrel Bisulfate 19,389,806  6
41 Propranolol Hydrochloride 17,749,819  2
42 Aspirin 17,299,288  4
43 Cyclobenzaprine 17,148,429  3
44 Hydrochlorothiazide; Lisinopril 16,687,918  9
45 Glipizide 16,619,798  1
46 Duloxetine 16,512,763  2
47 Methylphenidate 16,450,268 0
48 Ranitidine 16,369,541  2
49 Venlafaxine 16,080,521  2
50 Zolpidem Tartrate 15,899,894  10
51 Warfarin 15,190,524  10
52 Oxycodone 15,111,150  2
53 Ethinyl Estradiol; Norethindrone 14,961,803  2
54 Allopurinol 14,835,618  2
55 Ergocalciferol 14,578,147  1
56 Insulin Aspart 14,259,045  31
57 Azithromycin 12,690,152  8
58 Metronidazole 12,657,176  13
59 Loratadine 12,402,146  6
60 Lorazepam 12,359,439  3
61 Estradiol 12,358,564  2
62 Ethinyl Estradiol; Norgestimate 12,316,410  4
63 Lamotrigine 12,053,690  7
64 Glimepiride 12,044,087  3
65 Fluticasone Propionate; Salmeterol Xinafoate 12,025,244  3
66 Cetirizine 11,818,750  8
67 Hydrochlorothiazide; Losartan Potassium 11,752,545  13
68 Paroxetine 11,670,683  4
69 Spironolactone 11,641,507  3
70 Fenofibrate 11,535,943  3
71 Naproxen 11,334,305  3
72 Pregabalin 11,152,692  11
73 Insulin Human 10,617,873  11
74 Budesonide; Formoterol 10,587,157  3
75 Diltiazem Hydrochloride 10,486,476  12
76 Quetiapine Fumarate 10,402,693  10
77 Topiramate 10,388,097  8
78 Bacitracin; Neomycin; Polymyxin B 10,306,528  3
79 Clonidine 10,239,431  3
80 Buspirone Hydrochloride 10,195,216  10
81 Latanoprost 9,937,126  2
82 Tiotropium 9,507,922  13
83 Ondansetron 9,484,904  8
84 Lovastatin 9,453,814  12
85 Valsartan 9,231,279  7
86 Finasteride 9,132,613  11
87 Amitriptyline 9,105,080  1
88 Esomeprazole 9,036,551  19
89 Tizanidine 9,005,251  29
90 Alendronate Sodium 8,959,166  17
91 Lisdexamfetamine Dimesylate 8,884,101  8
92 Ferrous Sulfate 8,698,003  1
93 Apixaban 8,662,640  30
94 Diclofenac 8,557,078  16
95 Sitagliptin Phosphate 8,485,403  13
96 Folic Acid 8,284,498 0
97 Sumatriptan 8,126,158  18
98 Drospirenone; Ethinyl Estradiol 8,038,487  11
99 Hydroxyzine 7,944,928  2
100 Oxybutynin 7,935,806  8
101 Hydrochlorothiazide; Triamterene 7,631,431  41
102 Cephalexin 7,240,287  5
103 Triamcinolone 7,190,528  19
104 Benazepril Hydrochloride 7,163,351 0
105 Hydralazine Hydrochloride 7,117,425  33
106 Celecoxib 7,036,320  14
107 Ciprofloxacin 6,976,541  5
108 Ropinirole Hydrochloride 6,915,600  3
109 Rivaroxaban 6,836,386  4
110 Levetiracetam 6,832,916  21
111 Isosorbide Mononitrate 6,704,638  10
112 Aripiprazole 6,695,764  19
113 Doxycycline 6,681,548  3
114 Insulin Detemir 6,620,839  7
115 Famotidine 6,412,032  10
116 Amoxicillin; Clavulanate Potassium 6,398,915  2
117 Methotrexate 6,291,779  35
118 Hydrocodone Bitartrate 6,283,981  5
119 Mirtazapine 6,258,585  9
120 Nifedipine 6,213,120  34
121 Sulfamethoxazole; Trimethoprim 6,212,552  15
122 Enalapril Maleate 6,121,954  28
123 Docusate 6,107,372  4
124 Insulin Lispro 6,080,310  24
125 Pioglitazone 5,967,857  9
126 Divalproex Sodium 5,945,499  3
127 Donepezil Hydrochloride 5,677,780  29
128 Hydroxychloroquine Sulfate 5,666,999  7
129 Prednisolone 5,648,795  7
130 Thyroid 5,539,696  11
131 Guanfacine 5,451,594  25
132 Testosterone 5,441,196  14
133 Hydrochlorothiazide; Valsartan 5,341,254  1
134 Ramipril 5,318,556  19
135 Diazepam 5,184,805  23
136 Ethinyl Estradiol; Levonorgestrel 4,987,668  19
137 Clindamycin 4,934,442  14
138 Gemfibrozil 4,770,181  6
139 Metformin Hydrochloride; Sitagliptin Phosphate 4,735,729  52
140 Baclofen 4,587,435  16
141 Norethindrone 4,576,580  124
142 Temazepam 4,562,712  43
143 Nitroglycerin 4,538,115  37
144 Nebivolol Hydrochloride 4,473,865  18
145 Verapamil Hydrochloride 4,373,950  15
146 Timolol 4,369,477  4
147 Promethazine Hydrochloride 4,352,207  13
148 Benzonatate 4,335,738  45
149 Memantine Hydrochloride 4,327,217  2
150 Doxazosin Mesylate 4,313,778  7
151 Ezetimibe 4,260,208  7
152 Valacyclovir 4,230,834  16
153 Beclomethasone 4,202,266  23
154 Hydrocortisone 4,119,058  11
155 Morphine 4,090,362  3
156 Risperidone 4,075,364  3
157 Methylprednisolone 4,074,442  9
158 Omega-3-acid Ethyl Esters 3,925,744  19
159 Oseltamivir Phosphate 3,905,474  90
160 Amlodipine Besylate; Benazepril Hydrochloride 3,896,258  20
161 Meclizine Hydrochloride 3,861,963  1
162 Polyethylene Glycol 3350 3,802,924  15
163 Liraglutide 3,802,463  25
164 Desogestrel; Ethinyl Estradiol 3,797,028  31
165 Levofloxacin 3,777,117  4
166 Acyclovir 3,769,434  29
167 Brimonidine Tartrate 3,746,507 0
168 Digoxin 3,737,121  23
169 Adalimumab 3,722,094  19
170 Cyanocobalamin 3,718,963  33
171 Magnesium 3,700,740  8
172 Albuterol Sulfate; Ipratropium Bromide 3,622,793  6
173 Chlorthalidone 3,601,956  1
174 Glyburide 3,553,318  2
175 Levocetirizine Dihydrochloride 3,528,964  12
176 Carbamazepine 3,516,203  21
177 Ethinyl Estradiol; Etonogestrel 3,504,659  37
178 Methocarbamol 3,498,249  9
179 Pramipexole Dihydrochloride 3,375,277  25
180 Lithium 3,358,268  42
181 Dicyclomine Hydrochloride 3,290,774  3
182 Fluconazole 3,238,316  9
183 Nortriptyline Hydrochloride 3,229,716  9
184 Carbidopa; Levodopa 3,219,820  9
185 Nitrofurantoin 3,199,043  1
186 Mupirocin 3,140,100  13
187 Acetaminophen; Butalbital 3,117,810  15
188 Lansoprazole 3,109,062  47
189 Dexmethylphenidate Hydrochloride 3,102,541  20
190 Budesonide 3,077,886  17
191 Mirabegron 3,044,379  72
192 Canagliflozin 3,033,478  2
193 Menthol 2,990,164 0
194 Terazosin 2,936,433  25
195 Progesterone 2,930,452  6
196 Amiodarone Hydrochloride 2,908,848  2
197 Mometasone 2,894,532  32
198 Cefdinir 2,845,144  30
199 Atomoxetine Hydrochloride 2,831,375  46
200 Linagliptin 2,823,705  4

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2007-2017. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 20.0. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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