ClinCalc DrugStats Database

Free U.S. Outpatient Drug Usage Statistics

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The Top 200 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Total Patients (2018) Annual Change
1 Atorvastatin 112,474,023 23,393,083  1
2 Levothyroxine 105,773,990 19,448,097  1
3 Lisinopril 97,608,879 19,941,170  2
4 Metformin Hydrochloride 83,762,981 16,865,776 0
5 Amlodipine 75,811,947 15,851,641 0
6 Metoprolol 71,581,961 14,583,646 0
7 Albuterol 60,526,457 19,211,178  3
8 Omeprazole 58,364,556 13,410,605  1
9 Losartan Potassium 50,479,750 11,160,547 0
10 Simvastatin 48,007,043 10,407,988  2
11 Gabapentin 45,586,654 9,289,873 0
12 Acetaminophen; Hydrocodone Bitartrate 42,073,176 12,268,763  1
13 Hydrochlorothiazide 40,575,075 8,869,933  1
14 Sertraline Hydrochloride 38,383,042 7,529,389 0
15 Montelukast 35,222,630 7,017,347  1
16 Fluticasone 34,253,764 10,344,619  1
17 Amoxicillin 31,371,675 21,697,269  1
18 Furosemide 29,857,945 6,330,557  1
19 Pantoprazole Sodium 28,958,134 6,531,330 0
20 Acetaminophen 27,907,360 9,379,461  5
21 Prednisone 27,057,494 11,300,598  1
22 Escitalopram Oxalate 25,978,773 5,544,406  2
23 Fluoxetine Hydrochloride 25,619,277 4,752,127  8
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775 3,705,324  3
25 Tramadol Hydrochloride 24,952,328 6,952,833  7
26 Insulin Glargine 24,911,721 4,331,519  7
27 Bupropion 24,488,843 5,046,780  4
28 Ibuprofen 24,453,501 11,636,681 0
29 Rosuvastatin 24,138,061 5,257,942  10
30 Pravastatin Sodium 24,022,031 5,420,488  6
31 Trazodone Hydrochloride 23,889,624 4,677,140  1
32 Tamsulosin Hydrochloride 23,254,004 5,943,933  3
33 Carvedilol 22,737,638 4,403,579  4
34 Meloxicam 22,610,690 6,340,662  4
35 Citalopram 22,224,263 4,267,101  9
36 Duloxetine 21,217,653 3,946,472  10
37 Alprazolam 20,843,479 4,208,452  16
38 Potassium 20,414,037 4,619,520  1
39 Clopidogrel Bisulfate 20,016,095 4,467,091  1
40 Aspirin 19,750,180 5,004,736  2
41 Ranitidine 18,739,686 4,722,448  7
42 Atenolol 18,644,884 3,975,612  6
43 Cyclobenzaprine 18,041,836 6,033,831 0
44 Glipizide 17,549,602 3,506,779  1
45 Methylphenidate 17,467,265 2,569,210  2
46 Azithromycin 17,102,628 11,910,961  11
47 Clonazepam 17,064,643 2,792,493  13
48 Oxycodone 16,967,479 4,917,269  4
49 Allopurinol 16,374,431 3,374,614  5
50 Venlafaxine 16,121,149 2,870,792  1
51 Hydrochlorothiazide; Lisinopril 15,932,877 3,147,241  7
52 Warfarin 14,772,355 2,810,629  1
53 Propranolol Hydrochloride 14,571,767 3,302,645  12
54 Hydrochlorothiazide; Losartan Potassium 13,880,262 2,797,930  13
55 Cetirizine 13,799,351 3,840,211  11
56 Estradiol 13,583,025 3,131,795  5
57 Ethinyl Estradiol; Norethindrone 13,509,602 2,908,388  4
58 Lorazepam 13,222,989 3,033,521  2
59 Quetiapine Fumarate 12,962,563 2,046,378  18
60 Zolpidem Tartrate 12,877,940 2,858,753  10
61 Ergocalciferol 12,831,209 3,774,540  6
62 Budesonide; Formoterol 12,339,319 2,712,943  13
63 Spironolactone 12,260,624 2,610,298  6
64 Ondansetron 12,240,225 5,043,859  19
65 Insulin Aspart 12,146,568 2,375,787  9
66 Apixaban 12,113,153 2,560,506  27
67 Naproxen 11,942,765 4,823,303  5
68 Lamotrigine 11,582,775 1,758,591  5
69 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537 2,447,427  4
70 Pregabalin 11,429,654 2,183,817  3
71 Glimepiride 11,405,689 2,205,422  7
72 Diclofenac 11,372,069 3,853,876  22
73 Fenofibrate 11,325,402 2,402,673  3
74 Paroxetine 11,228,908 2,062,982  6
75 Clonidine 11,141,934 1,993,687  4
76 Loratadine 10,528,684 2,837,051  17
77 Diltiazem Hydrochloride 10,505,373 2,267,803  1
78 Hydroxyzine 10,431,206 2,769,471  21
79 Amitriptyline 10,282,767 1,980,001  8
80 Doxycycline 10,191,744 5,034,775  33
81 Ethinyl Estradiol; Norgestimate 10,166,878 2,289,108  19
82 Lisdexamfetamine Dimesylate 10,011,145 1,415,486  9
83 Sitagliptin Phosphate 9,813,527 1,868,303  12
84 Latanoprost 8,975,788 2,185,662  3
85 Cephalexin 8,938,064 5,845,428  17
86 Tizanidine 8,901,700 2,152,671  3
87 Finasteride 8,876,331 2,480,924  1
88 Lovastatin 8,769,143 2,039,445  4
89 Topiramate 8,648,513 1,625,584  11
90 Insulin Lispro 8,512,587 1,490,687  34
91 Sulfamethoxazole; Trimethoprim 8,448,278 4,340,806  30
92 Buspirone Hydrochloride 8,149,119 1,774,887  12
93 Oseltamivir Phosphate 8,139,836 5,363,483  66
94 Ferrous Sulfate 8,076,467 2,232,533  2
95 Amoxicillin; Clavulanate Potassium 7,974,978 5,600,348  21
96 Valsartan 7,694,037 1,834,658  11
97 Levetiracetam 7,666,166 1,208,963  13
98 Hydralazine Hydrochloride 7,545,026 1,670,423  7
99 Mirtazapine 7,504,257 1,405,315  20
100 Rivaroxaban 7,429,839 1,607,032  9
101 Aripiprazole 7,406,248 1,303,557  11
102 Oxybutynin 7,339,185 1,758,891  2
103 Esomeprazole 7,227,318 1,678,723  15
104 Alendronate Sodium 7,119,333 1,770,748  14
105 Folic Acid 7,099,659 1,793,345  9
106 Triamcinolone 6,848,479 3,995,753  3
107 Tiotropium 6,762,985 1,267,325  25
108 Thyroid 6,741,066 1,257,094  22
109 Ciprofloxacin 6,736,471 4,388,948  2
110 Isosorbide Mononitrate 6,698,824 1,418,224  1
111 Sumatriptan 6,674,685 1,805,282  14
112 Insulin Detemir 6,593,849 1,316,376  2
113 Benzonatate 6,493,593 3,881,071  35
114 Famotidine 6,470,718 1,739,478  1
115 Diazepam 6,448,085 1,907,386  20
116 Ropinirole Hydrochloride 6,224,574 1,266,850  8
117 Hydrochlorothiazide; Triamterene 6,007,404 1,416,877  16
118 Benazepril Hydrochloride 5,920,052 1,193,413  14
119 Metronidazole 5,852,534 3,215,002  61
120 Methocarbamol 5,849,167 1,697,450  58
121 Nifedipine 5,649,892 1,331,830  1
122 Baclofen 5,642,530 1,422,574  18
123 Methotrexate 5,518,246 1,045,632  6
124 Testosterone 5,483,791 1,166,009  8
125 Ezetimibe 5,476,606 1,279,335  26
126 Celecoxib 5,445,346 1,731,739  20
127 Guanfacine 5,429,776 745,584  4
128 Donepezil Hydrochloride 5,412,435 1,200,862  1
129 Hydroxychloroquine 5,406,190 1,275,750  1
130 Clindamycin 5,375,352 3,156,696  7
131 Divalproex Sodium 5,275,298 871,064  5
132 Morphine 5,225,088 729,631  23
133 Ethinyl Estradiol; Levonorgestrel 5,222,138 1,386,810  3
134 Prednisolone 5,202,600 2,812,650  5
135 Enalapril Maleate 5,182,854 1,075,972  13
136 Pioglitazone 5,178,776 1,106,190  11
137 Cyanocobalamin 5,107,466 1,211,053  33
138 Norethindrone 5,100,249 1,315,919  3
139 Meclizine Hydrochloride 4,960,255 1,586,691  22
140 Valacyclovir 4,931,639 2,087,445  12
141 Albuterol Sulfate; Ipratropium Bromide 4,789,978 1,131,554  31
142 Docusate 4,788,381 1,806,391  19
143 Liraglutide 4,771,233 914,595  20
144 Hydrocortisone 4,530,984 2,243,072  10
145 Verapamil Hydrochloride 4,492,362 764,704 0
146 Cefdinir 4,361,025 2,668,804  52
147 Nortriptyline Hydrochloride 4,346,899 1,014,388  36
148 Timolol 4,312,018 1,056,397  2
149 Dulaglutide 4,223,559 790,653  83
150 Promethazine Hydrochloride 4,171,551 1,506,832  3
151 Acyclovir 4,170,803 1,579,679  15
152 Fluconazole 4,115,042 2,435,456  30
153 Methylprednisolone 4,045,962 3,088,134  4
154 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205 727,627  15
155 Ramipril 3,989,667 951,186  21
156 Dexmethylphenidate Hydrochloride 3,961,348 633,049  33
157 Brimonidine Tartrate 3,929,927 949,982  10
158 Oxcarbazepine 3,915,508 611,913  49
159 Risperidone 3,909,621 705,780  3
160 Levofloxacin 3,892,600 2,031,179  5
161 Chlorthalidone 3,883,003 968,260  12
162 Atomoxetine Hydrochloride 3,848,913 585,517  37
163 Polyethylene Glycol 3350 3,829,568 1,361,406  1
164 Calcium; Cholecalciferol 3,824,225 939,825  72
165 Mupirocin 3,798,015 2,382,129  21
166 Ethinyl Estradiol; Etonogestrel 3,772,808 893,254  11
167 Drospirenone; Ethinyl Estradiol 3,759,495 742,476  69
168 Phentermine 3,683,239 1,084,123  42
169 Carbidopa; Levodopa 3,638,766 715,638  15
170 Omega-3-acid Ethyl Esters 3,635,260 915,458  12
171 Desogestrel; Ethinyl Estradiol 3,633,965 769,834  7
172 Guaifenesin 3,578,369 1,945,634  62
173 Rizatriptan Benzoate 3,490,815 791,854  31
174 Irbesartan 3,490,431 917,140  46
175 Progesterone 3,436,339 803,079  20
176 Doxazosin Mesylate 3,417,127 733,303  26
177 Linagliptin 3,390,520 523,666  23
178 Adalimumab 3,369,130 474,859  9
179 Nitrofurantoin 3,364,026 1,630,343  6
180 Budesonide 3,312,207 1,007,610  10
181 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178 795,990  21
182 Hydrochlorothiazide; Valsartan 3,261,560 782,002  49
183 Digoxin 3,251,214 691,227  15
184 Acetaminophen; Butalbital 3,242,635 584,606  3
185 Insulin Degludec 3,226,387 509,604  80
186 Ketoconazole 3,222,574 1,651,757  33
187 Nitroglycerin 3,182,971 1,273,543  44
188 Temazepam 3,173,561 694,970  46
189 Amiodarone Hydrochloride 3,171,077 721,402  7
190 Memantine Hydrochloride 3,129,750 752,433  41
191 Canagliflozin 3,108,372 573,704  1
192 Ketorolac Tromethamine 3,085,293 1,273,566  79
193 Liothyronine Sodium 3,081,151 546,776  59
194 Lithium 3,077,611 452,154  14
195 Dicyclomine Hydrochloride 3,076,088 1,029,343  14
196 Pramipexole Dihydrochloride 2,984,633 577,116  17
197 Nebivolol Hydrochloride 2,955,158 594,858  53
198 Terazosin 2,954,414 650,060  4
199 Magnesium 2,940,781 775,250  28
200 Colchicine 2,925,875 753,887  1

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.2. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Jul 3, 2021
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