RESULTS
An approximate corticosteroid dosing conversion:
Prednisone
60 mg
|
|
Methylprednisolone
48 mg
|
Dosage Forms
Methylprednisolone is available in the following dosage forms:
- Injection (40, 125, 500, 1000, 2000 mg)
- Depot injection (20 mg/mL as 5 mL); (40 mg/mL as 1 mL, 5 mL, 10 mL); (80 mg/mL as 1 mL, 5 mL)
- Oral tablet (2, 4, 8, 16, 32 mg)
The conversion (based on anti-inflammatory potency) is described with a great deal of variability in the literature.1,
2,
3,
4 This calculator uses the following anti-inflammatory potencies to convert between different corticosteroid compounds:
Fludrocortisone (Florinef) is used for its mineralocorticoid activity (causing increased reabsorption of sodium and loss of potassium/hydrogen). Although fludrocortisone technically possesses a small degree of anti-inflammatory activity (1/10th that of hydrocortisone), this effect is negibile at normal therapeutic doses of fludrocortisone (such as 0.05 to 0.2 mg per day). For this reason, fludrocortisone cannot realistically be converted to another corticosteroid on the basis of anti-inflammatory potency.