15 - 20%
|1. Glasgow coma score < 6||4||44.4%
|2. PaO2:FiO2 ratio ≤ 200 with resp support||3||33.3%
|3. MAP < 70 mmHg (without pressors)||1||11.1%
|4. Creatinine 1.2 - 1.9 mg/dL||1||11.1%
|5. Bilirubin < 1.2 mg/dL||0||0%
|6. Platelets > 150 (x103/mm3)||0||0%
Above: Hospital mortality rate associated with maximum SOFA score. The mortality rate was nearly 90% in patients with a SOFA score of more than 15.1
The Sequential Organ Failure Assessment (SOFA) is a morbidity severity score and mortality estimation tool developed from a large sample of ICU patients throughout the world. Unlike other scoring systems, such as the SAPS II and APACHE II systems, the SOFA was designed to focus on organ dysfunction and morbidity, with less of an emphasis on mortality prediction. The authors designed the system with an emphasis on bedside applicability and simplicity using widely available variables.
The study enrolled 1,449 patients from 40 intensive care units throughout the world during May 1995. The study excluded all patients < 13 years of age or were admitted for less than 48 hours for observation following an uncomplicated surgery.
The SOFA score is made of 6 variables, each representing an organ system. Each organ system is assigned a point value from 0 (normal) to 4 (high degree of dysfunction/failure) The worst physiological variables were collected serially every 24 hours of a patient's ICU admission. The "worst" measurement was defined as the measure that correlated to the highest number of points. The SOFA score ranges from 0 to 24.