Acinetobacter » Amikacin
≤ 8 mg/L
> 16 mg/L
Aminoglycoside breakpoints are based on once-daily administration of high aminoglycoside dosages. Most often aminoglycosides are given in combination with beta-lactam agents.
About This Calculator
An MIC (minimum inhibitory concentration) is the lowest drug concentration at which a given antimicrobial inhibits the growth of a particular organism. MIC breakpoints are MICs at which an organism should be considered susceptible, intermediate, or resistant.
Organizations, such as EUCAST (in Europe) and CLSI (in the United States), publish MIC breakpoint interpretations based on pharmacokinetic/pharmacodynamic data and clinical studies. These breakpoints typically are categorized into three groups: 1,2
- Susceptible: The organism should respond to therapy using recommended antimicrobial dosage for the given site of infection and species.
- Intermediate: The organism's MIC approaches or exceeds the threshold for normal antimicrobial dosing, but clinical response is possible with higher doses or if the antimicrobial concentrates at the site of infection.
- Resistant: The patient's organism should NOT be inhibited by concentrations achieved with normal dosing.
The "90-60" Rule
Generally speaking, "susceptible" infections respond to appropriate therapy approximately 90% of the time, whereas "resistant" infections respond only 60% of the time.2 With that said, patient-specific and pharmacokinetic factors have significant weight in determining clinical success.
These MIC tables are based on the 2012 EUCAST breakpoint tables.3 These tables are publically available for free on the EUCAST clinical breakpoints page. It should be noted that in the United States, most microbiology laboratories use the CLSI, not EUCAST, interpretive criteria for MICs.
Like EUCAST, CLSI breakpoints are updated on a yearly basis and are commonly used by microbiology laboratories in the United States. Unlike EUCAST, though, CLSI breakpoint tables are not publically available for free, and therefore will not appear on this site.
- Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general principles and contemporary practices. Clin Infect Dis. 2009;49(11):1749-55. PMID 19857164
- Kuper KM, Boles DM, Mohr JF, Wanger A. Antimicrobial susceptibility testing: a primer for clinicians. Pharmacotherapy. 2009;29(11):1326-43. PMID 19857149
- Clinical breakpoints (Bacterial v2.0 and Fungal v4.1). The European Committee on Antimicrobial Susceptibility Testing: http://www.eucast.org/clinical_breakpoints. Published January 1 and March 15, 2012 (respectively). Accessed July 21, 2012.